INT83797

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2011
Negated 0
Speculated 3
Reported most in Abstract
Documents 124
Total Number 128
Disease Relevance 94.55
Pain Relevance 22.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
liver 19
brain 3
poly 3
Notch 2
cecum 2
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 10 100.00 Very High Very High Very High
Paracetamol 379 99.84 Very High Very High Very High
Clonidine 3 99.60 Very High Very High Very High
Serotonin 6 99.50 Very High Very High Very High
antagonist 58 98.70 Very High Very High Very High
Central nervous system 8 98.68 Very High Very High Very High
withdrawal 6 97.84 Very High Very High Very High
methadone 2 97.54 Very High Very High Very High
tolerance 57 96.32 Very High Very High Very High
ischemia 33 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1667 100.00 Very High Very High Very High
Death 461 100.00 Very High Very High Very High
Cancer 1975 99.98 Very High Very High Very High
Skin Cancer 98 99.90 Very High Very High Very High
Breast Cancer 493 99.84 Very High Very High Very High
Glioblastoma 44 99.84 Very High Very High Very High
Stress 260 99.72 Very High Very High Very High
Metastasis 44 99.56 Very High Very High Very High
Hepatotoxicity 26 99.48 Very High Very High Very High
Ureteral Obstruction 84 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver homogenates subjected to western blot analysis disclosed the ability of 1X-PNM to counteract APAP-induced decrease in Bcl-xL expression.
Gene_expression (expression) of Bcl-xL in Liver associated with paracetamol
1) Confidence 0.77 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16902808 Disease Relevance 0.48 Pain Relevance 0.56
Pre-exposure to a novel nutritional mixture containing a series of phytochemicals prevents acetaminophen-induced programmed and unprogrammed cell deaths by enhancing BCL-XL expression and minimizing oxidative stress in the liver.
Gene_expression (expression) of BCL-XL in liver associated with stress and paracetamol
2) Confidence 0.77 Published 2006 Journal Mol. Cell. Biochem. Section Title Doc Link 16902808 Disease Relevance 0.32 Pain Relevance 0.20
Whether the consistent level of expression of BCL-X(S) reflected inability of AAP to influence its expression remains unknown.
Gene_expression (expression) of BCL-X associated with paracetamol
3) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.96 Pain Relevance 0.45
In the same time period, death inhibitory gene bcl-2 remained unexpressed, and the level of expression of BCL-X(S) remained unaltered.
Gene_expression (expression) of BCL-X associated with death
4) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.98 Pain Relevance 0.45
This investigation examined whether some aspects of the highly integrated process of acetaminophen (AAP)-induced hepatotoxicity involve down-regulation or upregulation of expression of BCL-2, BCL-X(L) and BCL-X(S) in mouse liver in vivo.
Gene_expression (expression) of BCL-X in liver associated with paracetamol and hepatotoxicity
5) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.72 Pain Relevance 0.46
Unaltered expression of BCL-X(S) in the near total absence of BCL-2 expression raises questions regarding the death promoting role of BCL-X(S) in vivo.
Gene_expression (expression) of BCL-X associated with death
6) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.83 Pain Relevance 0.45
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo.
Gene_expression (expression) of BCL-X in liver associated with paracetamol, apoptosis and death
7) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Title Doc Link 10663392 Disease Relevance 0.86 Pain Relevance 0.45
Western blot analysis of the liver proteins revealed that mouse liver expresses two proteins, BCL-X(L) and BCL-X(S), and does not express BCL-2.
Gene_expression (expresses) of BCL-X in liver
8) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 1.13 Pain Relevance 0.58
This investigation examined whether some aspects of the highly integrated process of acetaminophen (AAP)-induced hepatotoxicity involve down-regulation or upregulation of expression of BCL-2, BCL-X(L) and BCL-X(S) in mouse liver in vivo.
Gene_expression (expression) of BCL-X in liver associated with paracetamol and hepatotoxicity
9) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.72 Pain Relevance 0.47
Western blot analysis of the liver proteins revealed that mouse liver expresses two proteins, BCL-X(L) and BCL-X(S), and does not express BCL-2.
Gene_expression (expresses) of BCL-X in liver
10) Confidence 0.77 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 1.14 Pain Relevance 0.58
In summary, these observations demonstrate that GSPE preexposure may significantly attenuate AAP-induced hepatic DNA damage, apoptotic and necrotic cell death of liver cells, and, most remarkably, antagonize the influence of AAP-induced changes in bcl-Xl expression in vivo.
Gene_expression (expression) of bcl-Xl in liver associated with paracetamol, apoptosis and death
11) Confidence 0.74 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.58 Pain Relevance 0.63
Agarose gel electrophoresis revealed that 7-day GSPE preexposure prior to AAP administration completely blocked Ca(2+)/Mg(2+)-Ca(2+)/Mg(2+)-dependent-endonuclease-mediated ladder-like fragmentation of genomic DNA and significantly altered the bcl-Xl expression.
Gene_expression (expression) of bcl-Xl associated with paracetamol
12) Confidence 0.74 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.74 Pain Relevance 0.68
The most dramatic changes observed in this study were: (i) substantial increase in the expression of bcl-Xl in the liver by 7-day GSPE exposure alone; (ii) significant modification bcl-Xl expression by AAP alone; and (iii) dramatic inhibition of AAP-induced modification of bcl-Xl (phosphorylation?)
Gene_expression (expression) of bcl-Xl in liver associated with paracetamol
13) Confidence 0.74 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.70 Pain Relevance 0.70
A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver.
Gene_expression (expression) of Bcl-XL in liver associated with paracetamol and death
14) Confidence 0.74 Published 1999 Journal Arch. Biochem. Biophys. Section Title Doc Link 10462439 Disease Relevance 0.75 Pain Relevance 0.64
In fact, overexpression of Bcl-2 and Bcl-xL is observed in several cancers, including hematologic malignancies, as well as a range of solid tumors, including nasopharyngeal, colorectal, prostate, and breast cancer [5-7].
Gene_expression (overexpression) of Bcl-xL associated with cancer, breast cancer, solid tumor and hematologic neoplasms
15) Confidence 0.73 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.87 Pain Relevance 0
M AS Bcl-xL, mismatch, and random ODNs, on Bcl-xL protein expression in MDA-MB-231 and BT-474 cells (Fig. 3a).
Gene_expression (expression) of Bcl-xL protein in BT-474
16) Confidence 0.73 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.09 Pain Relevance 0
Another influencing factor might be a difference in the ability of sequence-specific AS ODNs to suppress Bcl-2 and Bcl-xL expression.
Gene_expression (expression) of Bcl-xL
17) Confidence 0.73 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.54 Pain Relevance 0
As shown in Fig. 8a, Bcl-xL expression was decreased on day 4, further decreased on day 6, and remained low 15 days after treatment with AS Bcl-xL.
Gene_expression (expression) of Bcl-xL
18) Confidence 0.73 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.65 Pain Relevance 0
Given that Bcl-2 and Bcl-xL are capable of inhibiting anticancer drug-induced apoptosis, which is mediated by the voltage-dependent anion channel (VDAC) in the outer mitochondrial membrane, overexpression of Bcl-2 and Bcl-xL might confer resistance to chemotherapy [4].
Gene_expression (overexpression) of Bcl-xL associated with apoptosis
19) Confidence 0.73 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.85 Pain Relevance 0
A 70% decrease in Bcl-xL protein expression was observed in cells treated with AS Bcl-xL ODNs, compared with control cells, but treatment with mismatch or random ODNs produced little change.
Gene_expression (expression) of Bcl-xL protein
20) Confidence 0.73 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.09 Pain Relevance 0

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