INT83798

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 30
Disease Relevance 20.26
Pain Relevance 4.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
Liver 4
hearts 4
Notch 2
neurons 2
cecum 2
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 71 99.82 Very High Very High Very High
ischemia 7 98.60 Very High Very High Very High
tolerance 15 96.32 Very High Very High Very High
cINOD 7 81.00 Quite High
antagonist 3 75.00 Quite High
palliative 3 70.28 Quite High
Potency 4 58.24 Quite High
aspirin 13 50.00 Quite Low
Analgesic 1 36.04 Quite Low
Crohn's disease 2 24.60 Low Low
Disease Link Frequency Relevance Heat
Cancer 547 100.00 Very High Very High Very High
Apoptosis 362 100.00 Very High Very High Very High
Stroke 1 100.00 Very High Very High Very High
Stress 104 99.96 Very High Very High Very High
Sprains And Strains 6 99.44 Very High Very High Very High
Stomach Cancer 16 99.16 Very High Very High Very High
Hematological Disease 12 98.92 Very High Very High Very High
Cv Unclassified Under Development 7 98.60 Very High Very High Very High
Death 112 98.44 Very High Very High Very High
Hepatocellular Cancer 241 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver homogenates subjected to western blot analysis disclosed the ability of 1X-PNM to counteract APAP-induced decrease in Bcl-xL expression.
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL in Liver associated with paracetamol
1) Confidence 0.58 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16902808 Disease Relevance 0.48 Pain Relevance 0.56
As shown in Fig. 8a, Bcl-xL expression was decreased on day 4, further decreased on day 6, and remained low 15 days after treatment with AS Bcl-xL.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-xL
2) Confidence 0.55 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.65 Pain Relevance 0
As shown in Fig. 8a, Bcl-xL expression was decreased on day 4, further decreased on day 6, and remained low 15 days after treatment with AS Bcl-xL.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-xL
3) Confidence 0.55 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.65 Pain Relevance 0
Compared to control, there was a considerable decrease in bcl-XL expression, and an increase in p53 expression in AAP-exposed livers.
Negative_regulation (decrease) of Gene_expression (expression) of bcl-XL in livers associated with paracetamol
4) Confidence 0.45 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11461765 Disease Relevance 0.59 Pain Relevance 0.82
Unaltered expression of BCL-X(S) in the near total absence of BCL-2 expression raises questions regarding the death promoting role of BCL-X(S) in vivo.
Negative_regulation (Unaltered) of Gene_expression (expression) of BCL-X associated with death
5) Confidence 0.42 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.83 Pain Relevance 0.45
Unaltered expression of BCL-X(S) in the near total absence of BCL-2 expression raises questions regarding the death promoting role of BCL-X(S) in vivo.
Negative_regulation (absence) of Gene_expression (expression) of BCL-X associated with death
6) Confidence 0.42 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.83 Pain Relevance 0.45
Agarose gel electrophoresis revealed that 7-day GSPE preexposure prior to AAP administration completely blocked Ca(2+)/Mg(2+)-Ca(2+)/Mg(2+)-dependent-endonuclease-mediated ladder-like fragmentation of genomic DNA and significantly altered the bcl-Xl expression.
Negative_regulation (altered) of Gene_expression (expression) of bcl-Xl associated with paracetamol
7) Confidence 0.41 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.74 Pain Relevance 0.68
Agarose gel electrophoresis revealed that 7-day GSPE preexposure prior to AAP administration completely blocked Ca(2+)/Mg(2+)-Ca(2+)/Mg(2+)-dependent-endonuclease-mediated ladder-like fragmentation of genomic DNA and significantly altered the bcl-Xl expression.
Negative_regulation (altered) of Gene_expression (expression) of bcl-Xl associated with paracetamol
8) Confidence 0.41 Published 1999 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 10462439 Disease Relevance 0.74 Pain Relevance 0.68
Similarly, downregulation of Bcl-xL protein expression by AS ODNs in various tumor cell lines resulted in activation of apoptosis, as well as decreased cellular proliferation and increased sensitivity to cytotoxic chemotherapeutic agents [15,16].
Negative_regulation (downregulation) of Gene_expression (expression) of Bcl-xL protein associated with cancer, apoptosis and hyperplasia
9) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.89 Pain Relevance 0
Another influencing factor might be a difference in the ability of sequence-specific AS ODNs to suppress Bcl-2 and Bcl-xL expression.
Negative_regulation (suppress) of Gene_expression (expression) of Bcl-xL
10) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.54 Pain Relevance 0
A 70% decrease in Bcl-xL protein expression was observed in cells treated with AS Bcl-xL ODNs, compared with control cells, but treatment with mismatch or random ODNs produced little change.
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL protein
11) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.09 Pain Relevance 0
The decrease in Bcl-xL protein expression by the treatment with AS Bcl-xL was confirmed by quantification by densitometric analysis (Fig. 3b).
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL protein
12) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.07 Pain Relevance 0
The decrease in Bcl-xL protein expression by the treatment with AS Bcl-xL was confirmed by quantification by densitometric analysis (Fig. 3b).
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL
13) Confidence 0.40 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.07 Pain Relevance 0
Quantitative measurements of apoptosis, Bax and Bcl-xL protein expression in the ApcMin mice revealed the ratio of Bax/Bcl-xL expression and apoptosis increased in the small intestine but decreased in the cecum, consistent with the regional tumorigenesis observed after sulindac.
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-xL in cecum associated with apoptosis
14) Confidence 0.37 Published 2003 Journal Carcinogenesis Section Abstract Doc Link 12663524 Disease Relevance 0.93 Pain Relevance 0.05
Since a cyclically induced strain, one of mechanical stress, reduces the expression of the cytoprotective factor Bcl-xL in a Notch signaling-dependent manner, and ultimately induces cell death in vascular smooth muscle cells in vitro [26], we focused on Bcl-xL expression.
Negative_regulation (reduces) of Gene_expression (expression) of Bcl-xL in Notch associated with stress, sprains and strains and death
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.64 Pain Relevance 0
Bcl-xL expression is decreased in Pn?
Negative_regulation (decreased) of Gene_expression (expression) of Bcl-xL
16) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.74 Pain Relevance 0
These data are consistent with the decrease of Bcl-xL expression in Pn?
Negative_regulation (decrease) of Gene_expression (expression) of Bcl-xL
17) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.83 Pain Relevance 0.13
Previous microarray analysis revealed that the expressions of Bcl-xL and Jak2 were downregulated in FL of CIAPIN1-null mice (15).
Negative_regulation (downregulated) of Gene_expression (expressions) of Bcl-xL
18) Confidence 0.23 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.29 Pain Relevance 0.03
In these in vitro studies, enhanced antiproliferative and apop-totic effects of rituximab and radiation were achieved through inhibition of c-myc and Bcl-xL expression.
Negative_regulation (inhibition) of Gene_expression (expression) of Bcl-xL
19) Confidence 0.22 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 0.34 Pain Relevance 0
Lapatinib reduced the levels of the two antiapoptotic proteins IAP-2 and Bcl-xL, and increased the levels of the proapoptotic protein Bak-1.
Negative_regulation (reduced) of Gene_expression (levels) of Bcl-xL
20) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.42 Pain Relevance 0

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