INT8380

Context Info Confidence 0.70 First Reported 1988 Last Reported 2009 Negated 3 Speculated 3 Reported most in Abstract Documents 49 Total Number 52 Disease Relevance 19.62 Pain Relevance 24.13

extracellular space (Npy) extracellular region (Npy)

Anatomy Link Frequency neurons 20 arcuate nucleus 10 plasma 8 brain 6 hypothalamus 4 Npy (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuropeptide 127 100.00 Enkephalin 13 100.00 Nucleus accumbens 9 100.00 primary afferent fibers 1 100.00 Clonidine 9 99.98 narcan 73 99.82 Peripheral nerve injury 7 99.72 cva 5 99.70 Hippocampus 3 99.68 Opioid 23 99.62

Disease Link Frequency Relevance Heat Injury 46 99.84 Obesity 6 99.80 Cv General 3 Under Development 4 99.70 Aids-related Complex 42 99.68 Affective Disorder 2 99.68 Nervous System Injury 36 99.28 Sprains And Strains 17 99.26 Diabetes Mellitus 25 99.12 Convulsion 5 99.00 Neuropathic Pain 32 98.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes.

Positive_regulation (detected) of Gene_expression (expression) of NPY in Arcuate nucleus associated with diabetes mellitus

1) Confidence 0.70 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.35 Pain Relevance 0.37

Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes.

Positive_regulation (Increased) of Gene_expression (expression) of NPY in Arcuate nucleus associated with diabetes mellitus

2) Confidence 0.70 Published 2004 Journal Acupunct Electrother Res Section Abstract Doc Link 15382790 Disease Relevance 0.35 Pain Relevance 0.37

Incubation of the hypothalamic explants with ghrelin significantly increased NPY and AGRP mRNA expression in the presence, but not absence, of dexamethasone.

Neg (not) Positive_regulation (increased) of Gene_expression (expression) of NPY associated with dexamethasone

3) Confidence 0.70 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.28

Glucocorticoids were also necessary for ghrelin action in vivo because an intracerebroventricular injection of ghrelin significantly increased NPY and AGRP mRNA expression in the arcuate nucleus only in sham-operated, but not in adrenalectomized rats.

Neg (not) Positive_regulation (increased) of Gene_expression (expression) of NPY in arcuate nucleus associated with intracerebroventricular

4) Confidence 0.70 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.30

In conclusion, our observations suggest that NPY overexpression leads to reduced neuronal activity following nerve injury in a cell-specific manner.

Positive_regulation (overexpression) of Gene_expression (overexpression) of NPY in neuronal associated with nervous system injury

5) Confidence 0.69 Published 2005 Journal Brain Res. Section Abstract Doc Link 16259969 Disease Relevance 0.88 Pain Relevance 0.34

Furthermore, NPY gene expression is induced within the population of medium- and large-diameter DRG neurons of the A beta-fiber class after experimental nerve injury.

Positive_regulation (induced) of Gene_expression (expression) of NPY gene in nerve associated with nervous system injury

6) Confidence 0.69 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.87 Pain Relevance 0.50

Induction of NPY gene expression in injured DRG neurons is consistent with appearance of NPY-LI-positive end bulbs derived from regenerating sensory axons that are found in developing neuromas containing a relatively high density of transported prejunctional Y2 receptors.

Positive_regulation (Induction) of Gene_expression (expression) of NPY gene in neurons associated with neuroma

7) Confidence 0.69 Published 1999 Journal Pain Section Abstract Doc Link 10068164 Disease Relevance 0.43 Pain Relevance 0.24

In accord with previous studies, NAL infusion significantly increased plasma LH levels at 1400 h. concomitant with this activation of LH release, NPY gene expression was also augmented.

Positive_regulation (augmented) of Gene_expression (expression) of NPY gene in plasma associated with narcan

8) Confidence 0.68 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.06 Pain Relevance 0.62

To examine further the relationship between the NAL-induced increase in LH release and increase in NPY gene expression, the effects of NPY mRNA antisense oligonucleotides (oligos) on NPY levels in the ME-ARC and on plasma LH levels were studied in NAL-infused rats.

Positive_regulation (increase) of Gene_expression (expression) of NPY gene in plasma associated with aids-related complex and narcan

9) Confidence 0.68 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.27 Pain Relevance 0.63

In conclusion, 1) high levels of gene expression and secretion of NPY are found in a rat insulinoma cell line (INS-1). 2) Accumulation of cAMP induced by forskolin or a gluco-incretin (GLP-1) induces a further increase in NPY gene expression and release. 3) NPY secretion is not modulated by low or high glucose concentrations in the medium. 4) Induction of NPY, a known inhibitor of insulin secretion, may represent a novel counterregulatory mechanism of insulin secretion, limiting the stimulatory effect of GLP-1 on insulin secretion.

Positive_regulation (increase) of Gene_expression (expression) of NPY gene associated with hypoglycemia

10) Confidence 0.68 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.16 Pain Relevance 0.17

Increased NPY expression persisted in neurons resistant to seizure-induced cell death (6-48 h after i.p.

Positive_regulation (Increased) of Gene_expression (expression) of NPY in neurons associated with convulsion and death

11) Confidence 0.66 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874238 Disease Relevance 0.44 Pain Relevance 0.07

These results suggest that the increased NPY expression in laminae 3-4 of the spinal cord (the territory of the myelinated sensory input) may be crucial to the development of hyperalgesia in this model.

Positive_regulation (increased) of Gene_expression (expression) of NPY in spinal cord associated with hyperalgesia and spinal cord

12) Confidence 0.64 Published 1995 Journal Pain Section Abstract Doc Link 8577486 Disease Relevance 0.34 Pain Relevance 1.06

Based on experiments in the pithed guinea-pig, it is suggested that prejunctional facilitatory beta-adrenoceptors may also be involved in the regulation of the NPY release, since infusion of isoprenaline elicited a facilitation of the PNS-induced increase of plasma NPY-LI levels which could be antagonised by propranolol.

Positive_regulation (increase) of Gene_expression (levels) of NPY in plasma

13) Confidence 0.50 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.30

Because a subpopulation of neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (Arc) projects to the PVN, we measured NPY and POMC mRNA expression in the Arc using in situ hybridization histochemistry at several time points following daily administration of four different antidepressant drugs.

Positive_regulation (measured) of Gene_expression (expression) of NPY in neurons associated with antidepressant, aids-related complex and neuropeptide

14) Confidence 0.50 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.42 Pain Relevance 0.33

RT-PCR analyses showed that mRNA expression levels of both NPY and POMC were markedly reduced by fluoxetine treatment in all parts of the brain examined, including the hypothalamus.

Positive_regulation (levels) of Gene_expression (expression) of NPY in hypothalamus associated with fluoxetine

15) Confidence 0.50 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 16042082 Disease Relevance 0.63 Pain Relevance 0.88

Collectively, these results show that a decrease in opioid influence rapidly augments NPY gene expression in a subpopulation of neurons in the ARC, and support the hypothesis that a disinhibition from opioid influence acutely promotes NPY synthesis and release, which is necessary for phasic LH discharge in rats.

Positive_regulation (augments) of Gene_expression (expression) of NPY gene in neurons associated with aids-related complex and opioid

16) Confidence 0.49 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.35 Pain Relevance 0.57

Furthermore, a marked upregulation of NPY (Y1) receptor mRNA expression was detected in the ipsilateral spinal dorsal horn 1 d and 3 d after inoculation.

Positive_regulation (upregulation) of Gene_expression (expression) of Y1 in dorsal horn associated with spinal dorsal horn

17) Confidence 0.49 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7965047 Disease Relevance 0.16 Pain Relevance 0.59

Two weeks after footshock treatment NPY mRNA expression was increased in the basolateral amygdala and showed preshockxnoise interaction in the locus coeruleus (down after noise in controls, lower basal and unchanged after noise in preshocked).

Positive_regulation (increased) of Gene_expression (expression) of NPY in locus coeruleus associated with locus ceruleus and amygdala

18) Confidence 0.48 Published 2008 Journal Brain Res. Section Abstract Doc Link 18440496 Disease Relevance 0.37 Pain Relevance 0.43

However, in other brain regions, fluoxetine administration caused a differential effect on the induction of NPY-related genes in the two rat strains: in the CA region and dentate gyrus NPY mRNA expression was increased in the FSL, but decreased in the FRL.

Positive_regulation (increased) of Gene_expression (expression) of NPY in dentate gyrus associated with sprains and strains and fluoxetine

19) Confidence 0.48 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.54 Pain Relevance 0.86

In the FSL rats, NPY mRNA expression levels were significantly decreased in the nucleus accumbens and CA regions, but increased in the arcuate nucleus and anterior cingulate cortex.

Positive_regulation (increased) of Gene_expression (expression) of NPY in anterior associated with nucleus accumbens and anterior cingulate cortex

20) Confidence 0.48 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.38 Pain Relevance 0.65

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