INT83821

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Context Info
Confidence 0.60
First Reported 1999
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.69
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
brain 4
midbrain 2
Htr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 4 100.00 Very High Very High Very High
Endep 3 99.74 Very High Very High Very High
antidepressant 3 98.88 Very High Very High Very High
Hippocampus 6 98.84 Very High Very High Very High
midbrain 1 98.46 Very High Very High Very High
fluoxetine 13 98.00 Very High Very High Very High
sSRI 6 89.16 High High
Dopamine 2 88.56 High High
tricyclic antidepressant 2 88.24 High High
Eae 1 81.04 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 96.44 Very High Very High Very High
Anxiety Disorder 6 88.32 High High
Hypertension 1 60.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential regulation of 5-HT1A receptor-G protein interactions in brain following chronic antidepressant administration.
Regulation (regulation) of 5-HT1A Binding (interactions) of in brain associated with antidepressant and endep
1) Confidence 0.60 Published 2002 Journal Neuropsychopharmacology Section Title Doc Link 11927181 Disease Relevance 0 Pain Relevance 0.62
Therefore, most imidazoline drugs modulated the synthesis of brain monoamines through interaction with alpha2-adrenoceptors or 5-HT1A receptors.
Regulation (modulated) of 5-HT1A Binding (interaction) of in brain associated with monoamine
2) Confidence 0.44 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10463334 Disease Relevance 0 Pain Relevance 0.38
In both strains, the 10 mg/kg dose of fluoxetine decreased hypothalamus 5-HT and 5-HIAA levels, and reduced midbrain and/or hippocampus [3H]citalopram binding at 5-HT transporters, but did not affect [3H]8-hydroxy-2-(di-N-propylamino)tetralin binding at hippocampal 5-HT1A receptors.
Neg (not) Regulation (affect) of 5-HT1A Binding (binding) of in midbrain associated with hippocampus, midbrain, sprains and strains and fluoxetine
3) Confidence 0.44 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10465693 Disease Relevance 0.69 Pain Relevance 1.02

General Comments

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