INT83822

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Context Info
Confidence 0.46
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.16
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
liver 2
Caco-2 1
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 2 96.04 Very High Very High Very High
cINOD 7 94.40 High High
Osteoarthritis 3 94.32 High High
headache 2 89.08 High High
Pain 3 85.36 High High
COX-2 inhibitor 3 81.60 Quite High
Arthritis 1 75.00 Quite High
Inflammation 2 74.32 Quite High
Inflammatory response 1 70.88 Quite High
agonist 20 66.96 Quite High
Disease Link Frequency Relevance Heat
Ulcers 2 99.40 Very High Very High Very High
Rheumatoid Arthritis 2 96.04 Very High Very High Very High
Osteoarthritis 3 94.32 High High
Dizziness 2 91.52 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 90.92 High High
Headache 2 89.08 High High
Pain 3 85.36 High High
Arthritis 1 75.00 Quite High
INFLAMMATION 4 74.32 Quite High
Sleep Initiation And Maintenance Disorders 24 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The metabolism, studied in rat, monkey and human liver, showed degradation by CYP1A1, CYP1A2, CYP2D6, and CYP2C9, and also some conjugation with glucuronic acid.71,73 Most of the metabolites have only been partially characterized and are, again, nonhomologous to those of melatonin (Figure 1), for fundamental reasons.
Protein_catabolism (degradation) of CYP2C9 in liver
1) Confidence 0.46 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2699659 Disease Relevance 0 Pain Relevance 0.06
Selected compounds were screened for cytochrome P450 inhibition (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4), metabolic stability (rat and human liver microsomes), and cell-membrane permeability (Caco-2).
Protein_catabolism (stability) of CYP2C9 in Caco-2
2) Confidence 0.17 Published 2006 Journal ChemMedChem Section Abstract Doc Link 16892345 Disease Relevance 0 Pain Relevance 0.11
Celecoxib is metabolized in the liver by the cytochrome P-450 isozyme CYP2C9, and thus serious drug interactions are possible.
Protein_catabolism (metabolized) of P-450 isozyme CYP2C9 in liver
3) Confidence 0.01 Published 1999 Journal Clin Ther Section Abstract Doc Link 10463513 Disease Relevance 1.07 Pain Relevance 1.14

General Comments

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