INT83826

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Context Info
Confidence 0.25
First Reported 1999
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.67
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 2 100.00 Very High Very High Very High
beta blocker 12 98.88 Very High Very High Very High
Angina 1 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 1 95.76 Very High Very High Very High
Cv General 3 Under Development 1 95.20 Very High Very High Very High
Myocardial Infarction 10 94.52 High High
Heart Rate Under Development 3 93.44 High High
Sudden Death 1 44.88 Quite Low
Arrhythmias 2 Under Development 1 31.32 Quite Low
Death 1 11.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardioprotection with beta-adrenoceptor blockers.
Negative_regulation (blockers.) of beta-adrenoceptor Binding (Cardioprotection) of
1) Confidence 0.25 Published 2000 Journal Basic Res. Cardiol. Section Title Doc Link 11192352 Disease Relevance 0.67 Pain Relevance 0.40
These compounds were found to be selective inhibitors of PNMT due to their decreased affinity for the alpha(2)-adrenoceptor, which was attributed to steric bulk intolerance around the 3-position of 1,2,3,4-tetrahydroisoquinoline (THIQ) at the alpha(2)-adrenoceptor and to the decreased pK(a) of the THIQ amine due to the 3-trifluoromethyl moiety.
Negative_regulation (decreased) of adrenoceptor Binding (affinity) of
2) Confidence 0.02 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10464018 Disease Relevance 0 Pain Relevance 0.10
A series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines was synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT) and as inhibitors of the binding of clonidine at the alpha(2)-adrenoceptor.
Negative_regulation (inhibitors) of adrenoceptor Binding (binding) of associated with clonidine
3) Confidence 0.02 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10464018 Disease Relevance 0 Pain Relevance 0.10

General Comments

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