INT83827

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Context Info
Confidence 0.02
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Adrb1, Pnmt) signal transduction (Adrb1) methyltransferase activity (Pnmt)
plasma membrane (Adrb1) nucleus (Adrb1) signal transducer activity (Adrb1)
Adrb1 (Mus musculus)
Pnmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 1 100.00 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines was synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT) and as inhibitors of the binding of clonidine at the alpha(2)-adrenoceptor.
Negative_regulation (inhibitors) of adrenoceptor Binding (binding) of phenylethanolamine N-methyltransferase associated with clonidine
1) Confidence 0.02 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10464018 Disease Relevance 0 Pain Relevance 0.10

General Comments

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