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Context Info
Confidence 0.02
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.10

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small molecule metabolic process (PNMT) cytoplasm (Adrb1) signal transducer activity (Adrb1)
cytosol (PNMT) signal transduction (Adrb1) methyltransferase activity (PNMT)
PNMT (Homo sapiens)
Adrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 1 100.00 Very High Very High Very High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A series of 3-trifluoromethyl-1,2,3,4-tetrahydroisoquinolines was synthesized and evaluated as inhibitors of phenylethanolamine N-methyltransferase (PNMT) and as inhibitors of the binding of clonidine at the alpha(2)-adrenoceptor.
PNMT Binding (binding) of adrenoceptor associated with clonidine
1) Confidence 0.02 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10464018 Disease Relevance 0 Pain Relevance 0.10

General Comments

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