INT83833

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Context Info
Confidence 0.72
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.57
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
ganglia 1
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 100 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
GABAergic 14 90.44 High High
amygdala 12 89.20 High High
Glutamate 14 74.72 Quite High
Dorsal horn 3 68.24 Quite High
spinal dorsal horn 1 62.80 Quite High
Central nervous system 8 54.04 Quite High
GABA receptor 17 51.32 Quite High
trigeminal ganglion 34 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 46 92.20 High High
Generalized Anxiety Disorder 35 83.84 Quite High
Cold Sores 2 72.28 Quite High
Pain 26 38.76 Quite Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although there are several reports that GAD65 and GABA are present in both neurons and SGCs of sensory ganglia [4,36,37], these papers have not been fully substantiated by other studies.
Localization (present) of GAD65 in ganglia associated with gaba
1) Confidence 0.72 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734545 Disease Relevance 0.52 Pain Relevance 0.70
Samples were probed with antiserum directed specifically against GAD65/67, PCNA and ?
Localization (directed) of GAD65
2) Confidence 0.32 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.05 Pain Relevance 0
To determine whether these regions may be subdivided further on a neurochemical basis, dual in situ hybridization was used to determine the colocalization of corticotropin-releasing hormone (CRH), enkephalin (ENK), or neurotensin (NT) with glutamic acid decarboxylase isoforms 65 and 67 [used concurrently as a marker for gamma-aminobutyric acid GABA] in these nuclei.
Spec (determine) Localization (colocalization) of decarboxylase isoforms 65 associated with gaba and enkephalin
3) Confidence 0.10 Published 1999 Journal J. Comp. Neurol. Section Abstract Doc Link 10464374 Disease Relevance 0 Pain Relevance 0.61

General Comments

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