INT83868

Context Info Confidence 0.01 First Reported 1999 Last Reported 1999 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.75

aging (Fos) nucleolus (Fos) nucleus (Fos) plasma membrane (Oprd1) DNA binding (Fos) transcription factor binding (Fos)

Oprd1 (Rattus norvegicus) Fos (Rattus norvegicus)

Pain Link Frequency Relevance Heat narcan 4 100.00 opioid receptor 3 100.00 antagonist 1 97.56 Opioid 2 97.12 Endogenous opioid 1 75.52 medulla 2 75.00 agonist 1 63.52 Pain 1 62.64

Disease Link Frequency Relevance Heat Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, opioid receptor antagonism with naloxone alone enhanced Fos expression in Vi/Vc and Vc in response to heat stimulation.

opioid receptor Positive_regulation (enhanced) of Gene_expression (expression) of Fos associated with narcan and opioid receptor

1) Confidence 0.01 Published 1999 Journal Pain Section Abstract Doc Link 10467925 Disease Relevance 0 Pain Relevance 0.75

General Comments

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