INT8388

Context Info Confidence 0.70 First Reported 1980 Last Reported 2011 Negated 10 Speculated 2 Reported most in Abstract Documents 142 Total Number 144 Disease Relevance 39.72 Pain Relevance 67.61

extracellular region (Vip)

Anatomy Link Frequency plasma 19 nerve 6 dorsal root ganglia 6 sciatic nerve 4 neurons 4 Vip (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neurotransmitter 407 100.00 Neuropeptide 303 100.00 substance P 198 100.00 Somatostatin 128 100.00 Enkephalin 118 100.00 Calcitonin gene-related peptide 94 100.00 Cholecystokinin 64 100.00 Dynorphin 26 100.00 adenocard 14 100.00 Neuronal nitric oxide synthase 1 100.00

Disease Link Frequency Relevance Heat Hyperglycemia 2 99.98 Increased Venous Pressure Under Development 20 99.96 INFLAMMATION 93 99.92 Stress 25 99.92 Cv Unclassified Under Development 1 99.88 Skin Allergy 15 99.84 Injury 90 99.82 Diabetes Mellitus 25 99.82 Nervous System Injury 39 99.76 Arthritis 80 99.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In dorsal root ganglia, RIA disclosed a 21% increase in VIP-LI, although no VIP-positive cells could be detected.

Positive_regulation (increase) of VIP in dorsal root ganglia

1) Confidence 0.70 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7566511 Disease Relevance 0.60 Pain Relevance 0.58

We tested the hypothesis that increases in the spinal levels of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were related to the development of neuropathic pain.

Positive_regulation (increases) of VIP in spinal associated with neuropathic pain and neuropeptide

2) Confidence 0.69 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12727330 Disease Relevance 0.40 Pain Relevance 0.48

Furthermore, VIP10-28, the C-terminal fragment that inhibits VIP stimulation of adenylate cyclase, reduced the number of surviving RGCs.

Positive_regulation (stimulation) of VIP

3) Confidence 0.69 Published 1990 Journal Neuron Section Abstract Doc Link 2169272 Disease Relevance 0.36 Pain Relevance 0.48

In addition, c-jun AS-ODN also suppressed the remarkable elevations of VIP and NPY mRNAs and the percentages of phosphorylated c-Jun-, VIP-, and NPY-immunoreactive neurons observed in DRGs following CCI.

Positive_regulation (elevations) of VIP in DRGs associated with eae

4) Confidence 0.68 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17081520 Disease Relevance 1.05 Pain Relevance 0.99

In contrast, SRIF seems to inhibit the VIP stimulation of prolactin release.

Positive_regulation (stimulation) of VIP

5) Confidence 0.67 Published 1981 Journal J. Physiol. (Paris) Section Abstract Doc Link 6122734 Disease Relevance 0 Pain Relevance 0.19

The spinal content of CGRP and SP decreased significantly 4 h after CRD, while galanin and VIP levels increased gradually and reached highest level at 24 h (p<0.05).

Positive_regulation (increased) of VIP in spinal associated with substance p and calcitonin gene-related peptide

6) Confidence 0.66 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 16084604 Disease Relevance 0.50 Pain Relevance 1.06

Vasoactive intestinal polypeptide (VIP), a marker of the cranial parasympathetic system, is increased during acute attacks of some primary headaches, and with its expression in the pituitary may link some pituitary tumours to their headache presentations.

Positive_regulation (increased) of VIP in pituitary associated with pituitary cancer and headache

7) Confidence 0.64 Published 2005 Journal Acta Neurol. Scand. Section Abstract Doc Link 15819711 Disease Relevance 0.99 Pain Relevance 0.45

In cats, bilateral electrical stimulation of the sciatic nerve at high, but not low intensity, resulted in a 218% and 132% increase above prestimulation baseline in the levels of CCK and VIP, respectively.

Positive_regulation (increase) of VIP in sciatic nerve associated with sciatic nerve and cholecystokinin

8) Confidence 0.64 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0 Pain Relevance 0.81

In rats, the addition of potassium (40 mM in excess) resulted in a 138% and 46% increase in the levels of CCK and VIP, respectively above resting levels (3.7 +/- 1.2 fmol/ml/10 min and 1.7 +/- 0.5 fmol/ml/10 min, respectively).

Positive_regulation (increase) of VIP associated with cholecystokinin

9) Confidence 0.64 Published 1982 Journal Brain Res. Section Abstract Doc Link 6896838 Disease Relevance 0.07 Pain Relevance 0.79

These observations suggest that NPY is primarily induced in myelinated primary afferent neurons, while VIP and GAL mRNA induction occurs in a mixed population, a sizeable percentage of which has unmyelinated axons.

Positive_regulation (induction) of VIP in afferent neurons associated with unmyelinated

10) Confidence 0.63 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7685398 Disease Relevance 0.07 Pain Relevance 0.66

Following the nerve cut, RNA blot analysis demonstrated a dramatic induction of NPY, VIP, and GAL mRNA levels from the undetectable constitutive level of expression.

Positive_regulation (induction) of VIP in nerve

11) Confidence 0.63 Published 1993 Journal J. Neurosci. Res. Section Abstract Doc Link 7685398 Disease Relevance 0.07 Pain Relevance 0.71

Plasma VIP is increased in active physical exercise and in transcutaneous nerve stimulation.

Positive_regulation (increased) of Plasma VIP in nerve associated with transcutaneous nerve stimulation

12) Confidence 0.61 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3609696 Disease Relevance 0.09 Pain Relevance 0.12

No significant increase in the plasma VIP was found.

Neg (No) Positive_regulation (increase) of plasma VIP in plasma

13) Confidence 0.61 Published 1987 Journal Gen. Pharmacol. Section Abstract Doc Link 3609696 Disease Relevance 0.09 Pain Relevance 0.13

V(mean MCA) decreased (16.3 +/- 5.9%) and diameter of STA increased significantly after VIP (45.9 +/- 13.9%).

Positive_regulation (increased) of VIP in STA

14) Confidence 0.60 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18254893 Disease Relevance 0.74 Pain Relevance 0.74

Increases in circulating VIP are known to stimulate secretion of renin.

Positive_regulation (Increases) of VIP

15) Confidence 0.60 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.16

Asbestos-related increase in pulmonary levels of vasoactive intestinal peptide (VIP).

Positive_regulation (increase) of VIP

16) Confidence 0.59 Published 1983 Journal Life Sci. Section Title Doc Link 6196589 Disease Relevance 0.25 Pain Relevance 0.44

Asbestos-related increase in pulmonary levels of vasoactive intestinal peptide (VIP).

Positive_regulation (increase) of vasoactive intestinal peptide

17) Confidence 0.59 Published 1983 Journal Life Sci. Section Title Doc Link 6196589 Disease Relevance 0.25 Pain Relevance 0.44

PACAP and VIP are known to be upregulated in primary sensory neurons following nerve injury, implying that these neuropeptides could be mediators of sensory transmission in neuropathic pain states.

Positive_regulation (upregulated) of VIP in nerve associated with nervous system injury, neuropathic pain and neuropeptide

18) Confidence 0.58 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225867 Disease Relevance 0.50 Pain Relevance 0.38

Studies on the additional involvement of an active local vasodilator have demonstrated a moderate increase in plasma vasoactive intestinal polypeptide (VIP) but excluded a series of known dilators.

Positive_regulation (increase) of VIP in plasma

19) Confidence 0.57 Published 1984 Journal Gen. Pharmacol. Section Abstract Doc Link 6714638 Disease Relevance 0.57 Pain Relevance 0.44

Vasoactive intestinal polypeptide (VIP), a marker of the cranial parasympathetic system, is increased during acute attacks of some primary headaches, and with its expression in the pituitary may link some pituitary tumours to their headache presentations.

Positive_regulation (increased) of intestinal polypeptide in pituitary associated with pituitary cancer and headache

20) Confidence 0.56 Published 2005 Journal Acta Neurol. Scand. Section Abstract Doc Link 15819711 Disease Relevance 0.99 Pain Relevance 0.45

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