INT83887

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Context Info
Confidence 0.77
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 7.99
Pain Relevance 3.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX2) oxidoreductase activity (HMOX2) endoplasmic reticulum (HMOX2)
plasma membrane (HMOX2) transmembrane transport (HMOX2)
Anatomy Link Frequency
joint 1
HMOX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 4 99.76 Very High Very High Very High
Inflammation 204 99.52 Very High Very High Very High
cINOD 9 98.54 Very High Very High Very High
Pain 15 97.96 Very High Very High Very High
Hyperalgesia 8 95.28 Very High Very High Very High
substance P 10 94.40 High High
Bile 10 93.28 High High
rheumatoid arthritis 90 92.56 High High
chemokine 8 91.76 High High
intrathecal 1 91.76 High High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 4 99.76 Very High Very High Very High
INFLAMMATION 280 99.52 Very High Very High Very High
Stomach Cancer 5 99.04 Very High Very High Very High
Endometriosis 9 98.36 Very High Very High Very High
Arthralgia 2 98.20 Very High Very High Very High
Synovitis 8 97.60 Very High Very High Very High
Injury 87 96.40 Very High Very High Very High
Hyperalgesia 8 95.28 Very High Very High Very High
Shock 6 94.72 High High
Disease 39 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND/AIMS: There have been investigations on the chemopreventive effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in gastric cancer and also on the association between cyclo-oxygenase 2 expression and the clinicopathological features of gastric cancer.
Gene_expression (expression) of cyclo-oxygenase 2 associated with inflammation, cinod and stomach cancer
1) Confidence 0.77 Published 2006 Journal Digestion Section Abstract Doc Link 16554658 Disease Relevance 0.46 Pain Relevance 0.32
In this context, our study is also the first to report changes in HO-2, the constitutive form of heme oxygenase that is largely responsible for production of carbon monoxide, another endogenous gaseous neuromodulator of considerable importance in the inhibitory control of gastrointestinal motility [3,21-25].
Gene_expression (production) of HO-2
2) Confidence 0.45 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2442096 Disease Relevance 0.67 Pain Relevance 0.18
BACKGROUND: Much recent effort has been made to produce selective inhibitors of cyclo-oxygenase-2 (COX-2) in the belief that these will lack the gastrointestinal damaging effects of traditional non-steroidal anti-inflammatory drugs (NSAIDs).
Gene_expression (produce) of cyclo-oxygenase-2 associated with inflammation and cinod
3) Confidence 0.17 Published 1999 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 10468690 Disease Relevance 0.26 Pain Relevance 0.42
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Gene_expression (expression) of cyclo-oxygenase-2
4) Confidence 0.16 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.57 Pain Relevance 0.21
Endometriotic lesions demonstrate increased aromatase expression in association with increased cyclo-oxygenase-2 expression, especially in red lesions which represent earlier stages of inflammation.
Gene_expression (expression) of cyclo-oxygenase-2 associated with endometriosis and inflammation
5) Confidence 0.15 Published 2009 Journal Minerva Ginecol Section Abstract Doc Link 19745796 Disease Relevance 1.07 Pain Relevance 0.33
In the temporomandibular joint (TMJ) synovium, cyclo-oxygenase-2 (COX-2) expression has been believed to be directly related to joint pain and synovitis.
Gene_expression (expression) of cyclo-oxygenase-2 in joint associated with pain, arthralgia, snapping jaw and synovitis
6) Confidence 0.10 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17384033 Disease Relevance 0.64 Pain Relevance 0.38
Three isoforms, HO-1, HO-2 and HO-3, are expressed in most tissues.
Gene_expression (expressed) of HO-2
7) Confidence 0.04 Published 2009 Journal J Transl Med Section Body Doc Link PMC2667492 Disease Relevance 1.02 Pain Relevance 0.21
HO-2 and HO-3 display a constitutive expression.
Gene_expression (expression) of HO-2
8) Confidence 0.03 Published 2009 Journal J Transl Med Section Body Doc Link PMC2667492 Disease Relevance 0.93 Pain Relevance 0.21
Activation of HIMECs by VEGF resulted in enhanced expression of cyclo-oxygenase-2 (COX-2) mRNA, protein and prostaglandin E2 (PGE2) production.
Gene_expression (expression) of cyclo-oxygenase-2
9) Confidence 0.02 Published 2008 Journal Gut Section Abstract Doc Link PMC2582343 Disease Relevance 0.67 Pain Relevance 0.19
SB203580 did not, however, affect the increased levels of interleukin-1beta and cyclo-oxygenase 2 protein observed in the hindpaw following complete Freund's adjuvant injection.
Gene_expression (levels) of cyclo-oxygenase 2 protein
10) Confidence 0.02 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11516436 Disease Relevance 0.89 Pain Relevance 0.83
IL-4 also decreases the mRNA production of cyclo-oxygenase 2 and cytosolic phospholipase A2, thereby reducing the levels of prostaglandin E2 [90,91].
Gene_expression (production) of cyclo-oxygenase 2
11) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.81 Pain Relevance 0.57

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