INT8389

Context Info Confidence 0.78 First Reported 1986 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 38 Total Number 39 Disease Relevance 5.11 Pain Relevance 21.39

extracellular region (Qrfp) cellular_component (Qrfp)

Anatomy Link Frequency brain 4 nerve 4 spinal cord 3 sensory nerve 2 pituitary 2 Qrfp (Rattus norvegicus)

Pain Link Frequency Relevance Heat Neuropeptide 473 100.00 substance P 87 100.00 Calcitonin gene-related peptide 74 100.00 Morphine 14 100.00 Enkephalin 10 100.00 neuropeptide release 9 100.00 Analgesic 11 99.92 projection neuron 7 99.92 anesthesia 1 99.92 agonist 48 99.84

Disease Link Frequency Relevance Heat Nervous System Injury 8 98.66 Glioma 4 98.32 Neuropathic Pain 12 98.24 Neurogenic Inflammation 11 98.08 Ganglion Cysts 4 97.88 Nociception 51 97.08 Injury 12 96.20 INFLAMMATION 38 90.00 Body Weight 35 87.88 Hypotension 1 77.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, little is known regarding the localization of 26RFa receptors.

Localization (localization) of 26RFa

1) Confidence 0.78 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17534937 Disease Relevance 0 Pain Relevance 0.27

In contrast, NMDA dose dependently stimulated neuropeptide FF release, even in the presence of the Na+ channel blocker, tetrodotoxin (1 microM), suggesting that NMDA receptors involved in the release of neuropeptide FF are mainly located on nerve terminals.

Localization (release) of neuropeptide FF in nerve associated with tetrodotoxin, nmda receptor and neuropeptide

2) Confidence 0.71 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7535231 Disease Relevance 0 Pain Relevance 0.79

Dual localization of neuropeptide FF receptors in the rat dorsal horn.

Localization (localization) of neuropeptide in dorsal horn associated with dorsal horn and neuropeptide

3) Confidence 0.70 Published 2000 Journal Synapse Section Title Doc Link 10579807 Disease Relevance 0.07 Pain Relevance 0.57

This study examined the effects of glutamate receptor agonists on the release of neuropeptide FF-like immunoreactivity from rat spinal dorsal half slices.

Localization (release) of neuropeptide FF in dorsal associated with glutamate receptor, neuropeptide and agonist

4) Confidence 0.62 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7535231 Disease Relevance 0 Pain Relevance 0.48

Modulation of neuropeptide FF release from rat spinal cord slices by glutamate.

Localization (release) of neuropeptide FF in spinal cord associated with glutamate, neuropeptide and spinal cord

5) Confidence 0.62 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 7535231 Disease Relevance 0 Pain Relevance 0.78

In contrast, NMDA dose dependently stimulated neuropeptide FF release, even in the presence of the Na+ channel blocker, tetrodotoxin (1 microM), suggesting that NMDA receptors involved in the release of neuropeptide FF are mainly located on nerve terminals.

Localization (release) of neuropeptide FF in nerve associated with tetrodotoxin, nmda receptor and neuropeptide

6) Confidence 0.54 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7535231 Disease Relevance 0 Pain Relevance 0.88

The results presented in this study demonstrate that neurokinin A, neuropeptide K and neurokinin B can be released by depolarizing stimuli from rat substantia nigra.

Localization (released) of neuropeptide K in substantia nigra associated with substantia nigra and neuropeptide

7) Confidence 0.27 Published 1988 Journal Neuroscience Section Abstract Doc Link 2905788 Disease Relevance 0 Pain Relevance 0.54

These results show that partial nerve injury to the sciatic nerve induces increases in the content of galanin, neuropeptide Y and calcitonin gene-related peptide immunoreactivities in synaptic terminals within the gracile nucleus, which suggests that there may be increased release of these neuropeptides following sensory or spontaneous stimulation of large-diameter primary afferents following partial nerve injury, perhaps one mechanism involved in neuropathic pain.

Localization (release) of neuropeptide in gracile nucleus associated with nervous system injury, neuropathic pain, neuropeptide, sciatic nerve and calcitonin gene-related peptide

8) Confidence 0.26 Published 1999 Journal Neuroscience Section Abstract Doc Link 10430497 Disease Relevance 0.64 Pain Relevance 0.94

Furthermore, immunoneutralization of neuropeptide FF increases endogenous and exogenous opioid-induced analgesia.

Localization (immunoneutralization) of neuropeptide associated with neuropeptide, opioid and analgesia

9) Confidence 0.22 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9593588 Disease Relevance 0.42 Pain Relevance 2.08

Ultrastructural localization of increased neuropeptide immunoreactivity in the axons and cells of the gracile nucleus following chronic constriction injury of the sciatic nerve.

Localization (localization) of neuropeptide in gracile nucleus associated with eae, injury, neuropeptide and sciatic nerve

10) Confidence 0.21 Published 1999 Journal Neuroscience Section Title Doc Link 10430497 Disease Relevance 0.51 Pain Relevance 0.80

Depolarization induces a Ca2+-dependent release of neuropeptide FF immunoreactivity from the spinal cord.

Localization (release) of neuropeptide in spinal cord associated with neuropeptide and spinal cord

11) Confidence 0.21 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9593588 Disease Relevance 0.29 Pain Relevance 1.31

Neuropeptide FF (NPFF), a morphine modulatory peptide, is localized within discrete autonomic regions including the brainstem nucleus tractus solitarius (NTS) and the parabrachial nucleus (PBN).

Localization (localized) of Neuropeptide in brainstem nucleus associated with medulla, neuropeptide, parabrachial and morphine

12) Confidence 0.19 Published 1998 Journal J. Comp. Neurol. Section Abstract Doc Link 9845244 Disease Relevance 0.29 Pain Relevance 0.74

The neuropeptide FF analogue, 1DME, enhances in vivo met-enkephalin release from the rat spinal cord.

Localization (release) of neuropeptide FF in spinal cord associated with analgesic, neuropeptide, enkephalin and spinal cord

13) Confidence 0.16 Published 1999 Journal Neuropharmacology Section Title Doc Link 10471085 Disease Relevance 0 Pain Relevance 1.05

The present work was to explore if beyond neuropeptide release, cisplatin at a treatment schedule attaining sensory neuropathy, produced changes in the expression of the receptors of sensory neuropeptides such as somatostatin, calcitonin gene-related peptide (CGRP) and substance P (SP) in bronchial tissue of the rat.

Localization (release) of neuropeptide associated with neuropathic pain, somatostatin, neuropeptide, substance p, calcitonin gene-related peptide and neuropeptide release

14) Confidence 0.16 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.27 Pain Relevance 0.49

An attenuated neurogenic broncho-constriction underpinned by a decrease in sensory neuropeptide release has been shown to be characteristic of cisplatin-induced neuropathy.

Localization (release) of neuropeptide associated with induced neuropathy, neuropathic pain and neuropeptide release

15) Confidence 0.16 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16343617 Disease Relevance 0.26 Pain Relevance 0.42

Activation of TRPV-1 leads to the release of the proinflammatory neuropeptide substance P (SP).

Localization (release) of neuropeptide associated with neuropeptide and substance p

16) Confidence 0.12 Published 2005 Journal Pancreas Section Abstract Doc Link 15782105 Disease Relevance 0.16 Pain Relevance 0.31

OBJECTIVE: To investigate the regulatory effects of nerve growth factor (NGF) on basal and capsaicin-induced release of neuropeptide substance P (SP) in primary cultured embryonic rat dorsal root ganglion (DRG) neurons.

Localization (release) of neuropeptide in neurons associated with ganglion cysts, dorsal root ganglion, qutenza, nerve growth factor, neuropeptide and substance p

17) Confidence 0.12 Published 2007 Journal Neuroscience bulletin Section Abstract Doc Link 17687396 Disease Relevance 0.17 Pain Relevance 0.41

Ultrastructural localization of neuropeptide FF, a new neuropeptide in the brain and pituitary of rats.

Localization (localization) of neuropeptide in brain associated with neuropeptide

18) Confidence 0.11 Published 1991 Journal Regul. Pept. Section Title Doc Link 1924889 Disease Relevance 0 Pain Relevance 0.44

Ultrastructural localization of neuropeptide FF, a new neuropeptide in the brain and pituitary of rats.

Localization (localization) of neuropeptide in brain associated with neuropeptide

19) Confidence 0.11 Published 1991 Journal Regul. Pept. Section Title Doc Link 1924889 Disease Relevance 0 Pain Relevance 0.44

CONCLUSION: SP, a neuropeptide secreted from sensory nerve endings, has been implicated in the pathophysiology of pain and has been shown to trigger MC secretion.

Localization (secreted) of neuropeptide in sensory nerve

20) Confidence 0.09 Published 1995 Journal Br J Urol Section Body Doc Link 7542136 Disease Relevance 0.22 Pain Relevance 0

General Comments

This test has worked.