INT83891

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Context Info
Confidence 0.61
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 10.49
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT3) Golgi apparatus (FUT3)
Anatomy Link Frequency
Blood 4
Sublingual 2
LES 1
Plasma 1
FUT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 51 99.70 Very High Very High Very High
beta blocker 6 96.68 Very High Very High Very High
Angina 67 95.04 Very High Very High Very High
endometriosis 4 83.40 Quite High
Calcium channel 11 77.52 Quite High
agonist 7 73.84 Quite High
substance P 27 71.92 Quite High
nud 23 69.24 Quite High
Inflammatory mediators 14 66.24 Quite High
headache 8 59.32 Quite High
Disease Link Frequency Relevance Heat
Achalasia 395 99.84 Very High Very High Very High
INFLAMMATION 62 99.70 Very High Very High Very High
Disorder Of Lipid Metabolism 16 98.24 Very High Very High Very High
Myocardial Infarction 9 97.00 Very High Very High Very High
Esophageal Cancer 13 95.84 Very High Very High Very High
Gastroesophageal Reflux Disease 266 95.60 Very High Very High Very High
Acid Reflux 80 95.44 Very High Very High Very High
Cv General 3 Under Development 6 95.04 Very High Very High Very High
Dysphagia 54 93.92 High High
Esophageal Disease 36 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly to FUT3 variant, the association was stronger for men (for total cholesterol, p?
Gene_expression (variant) of FUT3 associated with disorder of lipid metabolism
1) Confidence 0.61 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2574036 Disease Relevance 0.41 Pain Relevance 0
No statistically significant improvement in LES pressure compared with baseline was observed in the Gatekeeper group at 6 months (p = 0.079) and 12 months (p = 0.246) (Tables 4, 5).
Gene_expression (pressure) of LES
2) Confidence 0.42 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2869435 Disease Relevance 0.33 Pain Relevance 0
Esophageal manometry (LES pressure)
Gene_expression (pressure) of LES
3) Confidence 0.42 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2869435 Disease Relevance 0.39 Pain Relevance 0
was <4; 9.1% decreased to 6.1%), and LES pressure (8.8 mmHg improved to 13.8 mmHg) at 6 months.
Gene_expression (pressure) of LES
4) Confidence 0.42 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2869435 Disease Relevance 0.44 Pain Relevance 0
The improvements in esophageal functions (esophageal acid exposure and LES pressure) in the active treatment group were minimal and not clinically meaningful.
Gene_expression (pressure) of LES
5) Confidence 0.42 Published 2010 Journal Surg Endosc Section Body Doc Link PMC2869435 Disease Relevance 0.54 Pain Relevance 0
Sublingual isosorbide dinitrate is also effective in decreasing LES pressure in achalasia patients, resulting in symptom improvement in 53% to 87% of patients.
Gene_expression (pressure) of LES in Sublingual associated with achalasia
6) Confidence 0.38 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.24 Pain Relevance 0.11
Up to 40% of the patients with achalasia have normal LES pressure (10–40 mm Hg); however, low pressure LES is not seen in untreated achalasia patients [47].
Gene_expression (pressure) of LES associated with achalasia
7) Confidence 0.38 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 1.30 Pain Relevance 0.17
In a study comparing the effect of sublingual nifedipine to sublingual isosorbide dinitrate, both drugs decreased LES pressure, but the effect of nitrate was slightly better than that of nifidipine (65% vs. 49% respectively) [53].
Gene_expression (pressure) of LES in sublingual
8) Confidence 0.38 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.21 Pain Relevance 0.06
However, this study also indicates that despite lower LES pressure, patients undergoing PD after failed myotomy do not do as well as untreated cases [11].
Gene_expression (pressure) of LES
9) Confidence 0.38 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.50 Pain Relevance 0.03
Table 1 reflects the symptom response rate as well as percent of LES pressure drop after treatment with BT over a period of 12 months in most valuable studies.
Gene_expression (pressure) of LES
10) Confidence 0.38 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2040141 Disease Relevance 0.21 Pain Relevance 0.06
The pH probe was positioned 5 cm above the position of the LES.
Gene_expression (position) of LES
11) Confidence 0.30 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.30 Pain Relevance 0.03
Essentially the same inflammatory processes are present in the body of the esophagus and in the LES.
Gene_expression (present) of LES in LES associated with inflammation
12) Confidence 0.16 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.84 Pain Relevance 0.31
Blood HO-PCB concentrations in Yusho patients and normal persons are higher than the FT3, FT4 levels in serum.
Gene_expression (levels) of FT4 in Blood
13) Confidence 0.05 Published 2009 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 19588843 Disease Relevance 0.35 Pain Relevance 0.04
Blood HO-PCB concentrations in Yusho patients and normal persons are higher than the FT3, FT4 levels in serum.
Gene_expression (levels) of FT3 in Blood
14) Confidence 0.05 Published 2009 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 19588843 Disease Relevance 0.35 Pain Relevance 0.04
Blood PCB concentrations in normal Japanese are higher than the FT3 and FT4 levels, indicating hormonal disturbance will be easily produced.
Gene_expression (levels) of FT4 in Blood
15) Confidence 0.04 Published 2009 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 19588843 Disease Relevance 0.56 Pain Relevance 0.10
Blood PCB concentrations in normal Japanese are higher than the FT3 and FT4 levels, indicating hormonal disturbance will be easily produced.
Gene_expression (levels) of FT3 in Blood
16) Confidence 0.04 Published 2009 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 19588843 Disease Relevance 0.57 Pain Relevance 0.10
The treatment goal is to reduce the LES pressure.
Gene_expression (pressure) of LES
17) Confidence 0.03 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990396 Disease Relevance 1.69 Pain Relevance 0
Lower levels of FT3, FT4 and TSH were found in centenarians’ children and nieces/nephews with respect to age-matched controls.
Gene_expression (levels) of FT3
18) Confidence 0.01 Published 2010 Journal Age and Ageing Section Abstract Doc Link PMC2956534 Disease Relevance 0.14 Pain Relevance 0
MEASUREMENTS: In all patients, pre- and post- operative measurements were made of FT4, FT3, TSH, PRL, LH, FSH, cortisol (0900 h), GH, oestradiol (females) and testosterone (males).
Gene_expression (made) of FT3
19) Confidence 0.00 Published 1999 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 10468988 Disease Relevance 0.09 Pain Relevance 0
Plasma triiodothyronine (T3), reverse T3 (rT3), free T3 (FT3), thyroxine (T4), free T4 (FT4), thyroid-stimulating hormone (TSH), thyroxine-binding globulin (TBG), and albumin (ALB) levels were determined in 95 patients (59 males, 36 females, aged 58.4+/-9) with AMI and 19 patients (13 males, 6 females aged 54.7+/-12.3) with UA for 5 consecutive days from the onset of the acute syndrome and 1 month later.
Gene_expression (levels) of FT3 in Plasma associated with angina, syndrome and myocardial infarction
20) Confidence 0.00 Published 2002 Journal Angiology Section Abstract Doc Link 12463624 Disease Relevance 1.01 Pain Relevance 0.37

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