INT83894

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 18.28
Pain Relevance 11.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (TRPM8)
Anatomy Link Frequency
bladder 6
plasma 1
external 1
central nervous system 1
nerve 1
TRPM8 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 52 100.00 Very High Very High Very High
sodium channel 13 100.00 Very High Very High Very High
Kinase C 12 99.98 Very High Very High Very High
Pain 342 99.84 Very High Very High Very High
dorsal root ganglion 113 99.60 Very High Very High Very High
allodynia 16 99.24 Very High Very High Very High
Neuropathic pain 8 98.56 Very High Very High Very High
antagonist 24 98.54 Very High Very High Very High
Pain score 63 98.00 Very High Very High Very High
Dorsal horn 9 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 3 100.00 Very High Very High Very High
Frostbite 5 99.90 Very High Very High Very High
Malignant Neoplastic Disease 27 99.84 Very High Very High Very High
Ganglion Cysts 125 99.60 Very High Very High Very High
Bladder Disease 306 99.52 Very High Very High Very High
Erythema 4 99.40 Very High Very High Very High
Neuropathic Pain 64 99.24 Very High Very High Very High
Fever 2 98.42 Very High Very High Very High
Nociception 22 98.22 Very High Very High Very High
Overactive Bladder 235 98.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further correlations with clinical studies, such as the ice water test (to elicit the bladder cooling reflex in both PBS and detrusor overactivity) and more accurate methods of clinical measurement, including voiding diaries and urodynamic results, are in progress to determine the functional consequences of the TRPM8 receptor increase.


Positive_regulation (increase) of TRPM8 receptor in bladder associated with overactive bladder and bladder disease
1) Confidence 0.70 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.98 Pain Relevance 0.35
A salient finding of the study was a five-fold increase of TRPM8-immunoreactive axons (ummyelinated fibres) in PBS as compared to controls.
Positive_regulation (increase) of TRPM8-immunoreactive associated with bladder disease
2) Confidence 0.70 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 1.04 Pain Relevance 0.81
This study shows a significant increase of TRPM8-immunoreactive nerve fibres in suburothelium from patients with overactive and painful bladder syndrome.
Positive_regulation (increase) of TRPM8-immunoreactive in bladder associated with pain and bladder disease
3) Confidence 0.70 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.99 Pain Relevance 0.38
Compared to controls, a three- and five-fold increase of TRPM8-immunoreactive axons was seen in IDO and PBS groups respectively.
Positive_regulation (increase) of TRPM8-immunoreactive associated with bladder disease
4) Confidence 0.70 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.72 Pain Relevance 0.19
The presence of increased immunoreactivity in nerve bundles may indicate increased levels of axonally transported TRPM8 in IDO and PBS bladders.
Positive_regulation (increased) of TRPM8 in bladders associated with bladder disease
5) Confidence 0.70 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.51 Pain Relevance 0.53
The aim of this study was to evaluate the psychophysical effects of both TRPA1 and TRPM8 activation in humans by application of either cinnamaldehyde or menthol.
Positive_regulation (activation) of TRPM8
6) Confidence 0.69 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931068 Disease Relevance 0.34 Pain Relevance 0.43
In contrast, TRPM8 activation by menthol produced no axon reflex reaction and resulted in cold hyperalgesia.
Positive_regulation (activation) of TRPM8 associated with hyperalgesia and cold hyperalgesia
7) Confidence 0.69 Published 2005 Journal Neuroreport Section Abstract Doc Link 15931068 Disease Relevance 0.49 Pain Relevance 0.57
TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol.
Positive_regulation (activation) of TRPM8 associated with pain
8) Confidence 0.69 Published 2005 Journal Neuroreport Section Title Doc Link 15931068 Disease Relevance 0.39 Pain Relevance 0.68
TRPM8 is activated directly by gentle cooling and depolarises sensory neurones; its threshold temperature (normally approximately 26-31 degrees C in native neurones) is very flexible and it can adapt to long-term variations in baseline temperature to sensitively detect small temperature changes.
Positive_regulation (activated) of TRPM8
9) Confidence 0.69 Published 2005 Journal Pflugers Arch. Section Abstract Doc Link 16075243 Disease Relevance 0.15 Pain Relevance 0.10
Menthol, popularly known for its cooling effect, activates TRPM8--a cold-activated thermoTRP ion channel.
Positive_regulation (activates) of TRPM8
10) Confidence 0.64 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16829128 Disease Relevance 0.10 Pain Relevance 0.17
TRPM8 is also activated by the cooling agents menthol and icilin.
Positive_regulation (activated) of TRPM8
11) Confidence 0.61 Published 2004 Journal Neuron Section Abstract Doc Link 15363396 Disease Relevance 0 Pain Relevance 0.04
Hence, Yo-Pro uptake occurs upon activation of TRPA1, but not TRPM8.
Positive_regulation (activation) of TRPM8
12) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2633278 Disease Relevance 0 Pain Relevance 0.14
Activation of TRPM8 or TRPV1 at first sensory synapse between DRG and DH neurons leads to a robust increase in frequency of spontaneous/miniature EPSCs.
Positive_regulation (Activation) of TRPM8 in synapse associated with dorsal root ganglion and dorsal horn
13) Confidence 0.56 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16339027 Disease Relevance 0.51 Pain Relevance 0.81
In the present study, we show that TRPM8-immunoreactive nerve fibres were significantly increased in painful bladder syndrome, and correlated with pain score.
Positive_regulation (increased) of TRPM8-immunoreactive in bladder associated with pain, pain score and bladder disease
14) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.60 Pain Relevance 0.56
Recently another temperature sensitive receptor, TRPM8, activated by menthol and cool temperatures (8C to 28C) was described that may be the proposed cool receptor, at least in part mediating the bladder response in the diagnostic ice water test.
Positive_regulation (activated) of TRPM8 in bladder
15) Confidence 0.50 Published 2004 Journal J. Urol. Section Abstract Doc Link 15311065 Disease Relevance 0.09 Pain Relevance 0.09
We report evidence from immunofluorescence experiments that in the androgen-responsive LNCaP cell line, the TRPM8 protein is expressed in the endoplasmic reticulum and plasma membrane, acts as a Ca(2+)-permeable channel (assessed using Fura-2 to measure increases in the cytoplasmic Ca(2+) concentration) in each of these membranes, and is regulated by androgen.
Positive_regulation (acts) of TRPM8 protein in plasma
16) Confidence 0.50 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548706 Disease Relevance 0.26 Pain Relevance 0.04
The results of experiments using LNCaP cells, the TRPM8 antagonist capsazepine, and small interference RNA targeted to TRPM8 indicate that TRPM8 is required for cell survival.
Positive_regulation (required) of TRPM8 associated with antagonist
17) Confidence 0.50 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548706 Disease Relevance 0.22 Pain Relevance 0.05
This study demonstrates increased TRPM8 in nerve fibres of overactive and painful bladders, and its relationship with clinical symptoms.
Positive_regulation (increased) of TRPM8 in bladders associated with pain
18) Confidence 0.47 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1420318 Disease Relevance 0.40 Pain Relevance 0.31
In addition, an increase in TRPM8-immunoreactive nerve fibres in IDO and PBS, suggests that TRPM8 may contribute to the increased frequency which is a prominent symptom in these conditions.
Positive_regulation (increase) of TRPM8-immunoreactive in nerve associated with bladder disease
19) Confidence 0.47 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.59 Pain Relevance 0.20
TRPM8 was initially identified as a prostate-specific TRP channel that was upregulated in malignant tissue [14].
Positive_regulation (upregulated) of TRPM8 associated with malignant neoplastic disease and trp channel
20) Confidence 0.47 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.10 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox