INT83896

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 15.58
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1A) plasma membrane (CD1A)
Anatomy Link Frequency
CD86 3
monocyte 2
histiocytes 1
smooth muscle 1
dendritic cells 1
CD1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 103 99.04 Very High Very High Very High
Neuritis 15 98.48 Very High Very High Very High
fibrosis 8 93.12 High High
Arthritis 21 86.24 High High
Central nervous system 10 85.44 High High
Multiple sclerosis 4 84.84 Quite High
Pain 10 83.80 Quite High
Inflammation 58 83.60 Quite High
shoulder pain 1 81.16 Quite High
headache 7 77.72 Quite High
Disease Link Frequency Relevance Heat
Histiocytic Sarcoma 99 100.00 Very High Very High Very High
Cancer 252 99.56 Very High Very High Very High
Hookworm Infection 105 99.34 Very High Very High Very High
Leiomyosarcoma 36 99.08 Very High Very High Very High
Optic Neuritis 11 98.48 Very High Very High Very High
Pressure And Volume Under Development 51 98.46 Very High Very High Very High
Epithelioid Leiomyoma 8 98.42 Very High Very High Very High
Hypersensitivity 10 97.86 Very High Very High Very High
Langerhans-cell Histiocytosis 10 96.76 Very High Very High Very High
Juvenile Xanthogranuloma 3 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vast majority of neoplastic cells were intensely positive for S-100 and CD1a.
Gene_expression (positive) of CD1a
1) Confidence 0.68 Published 1999 Journal Pathol. Int. Section Abstract Doc Link 10469399 Disease Relevance 0.64 Pain Relevance 0.08
Particularly the fraction of DC expressing CD1a and CD80 was significantly higher in ON than in HC (P<0.05).
Gene_expression (expressing) of CD1a associated with neuritis
2) Confidence 0.64 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 19948167 Disease Relevance 1.11 Pain Relevance 0.93
These same hookworm-infected individuals also presented significantly down-regulated expression of CD86, CD1a, HLA-ABC, and HLA-DR.
Gene_expression (expression) of CD1a in CD86 associated with hookworm infection
3) Confidence 0.40 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.57 Pain Relevance 0
The neoplastic cells express CD1a and S-100 protein but lack cytoplasmic Birbeck granules [1].
Gene_expression (express) of CD1a
4) Confidence 0.40 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.45 Pain Relevance 0.04
By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a.
Neg (negative) Gene_expression (negative) of CD1a in histiocytes
5) Confidence 0.39 Published 2001 Journal Mod. Pathol. Section Abstract Doc Link 11266522 Disease Relevance 1.02 Pain Relevance 0.41
SRCD spectra for untagged P2 were collected on beamline CD1 of the ASTRID storage ring at the University of Ã…rhus, Denmark.
Gene_expression (collected) of CD1
6) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858655 Disease Relevance 0 Pain Relevance 0
Additionally, hookworm-infected individuals have lower expression of costimulatory (CD86) and antigen presenting molecules (CD1a, HLA-ABC, HLA-DR), which was coincident with a reduced ability of the DCs to induce cell proliferation.
Gene_expression (expression) of CD1a in CD86 associated with hookworm infection
7) Confidence 0.31 Published 2009 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2654967 Disease Relevance 0.87 Pain Relevance 0.04
Matured dendritic cells were stained using monoclonal antibodies to determine the expression of antigen-presentation molecules (HLA-DR, HLA-ABC and CD1a), co-stimulatory molecules (CD86, CD80 and CD40), and other monocyte markers (CD14, CD11c and CD16).
Spec (determine) Gene_expression (expression) of CD1a in dendritic cells
8) Confidence 0.31 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.23 Pain Relevance 0
Interestingly, although lamina propria of ectocervix showed the presence of primitive (CD14) moderately (HLA-DR) and well differentiated MDC (CD68), the monocyte-derived cells entering epithelium appear to initiate a new differentiation associated with CD1a expression and HLA-DR and CD68 secretion.


Gene_expression (expression) of CD1a in monocyte
9) Confidence 0.24 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.07 Pain Relevance 0
Similar to leptin effect on monocytes,it may increase the survival of dendritic cells, and it may also increase the expression of surface molecules, such as CD1a, CD80, CD83, or CD86.
Gene_expression (expression) of CD1a in monocytes
10) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.20 Pain Relevance 0.07
Of special interest is that all of the cases showed CD56 expression on the tumor cells in addition to expression of CD1a, S100beta, and langerin, the presence of which suggests derivation from Langerhans cells.
Gene_expression (expression) of CD1a in Langerhans cells associated with cancer
11) Confidence 0.16 Published 2005 Journal Int. J. Hematol. Section Abstract Doc Link 15914364 Disease Relevance 1.16 Pain Relevance 0.08
The vast majority of lymphocytes in the perivascular spaces and in the lobulated tumor were immunohistochemically positive for TdT, MIC2, and CD1a.
Gene_expression (positive) of CD1a in lymphocytes associated with cancer
12) Confidence 0.14 Published 2006 Journal Virchows Arch. Section Abstract Doc Link 16673117 Disease Relevance 1.15 Pain Relevance 0.08
The neoplastic cells were negative for CD43, ALK, CD30, EMA, smooth muscle actin, cytokeratin, desmin, myogenin, TTF1, CD99, CD1a, LMP-1, CD117, HMB45, and Mart-1/Melan A.
Gene_expression (negative) of CD1a in smooth muscle
13) Confidence 0.14 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.54 Pain Relevance 0
Immature dendritic cells (iDCs) present in the liver express low levels of MHC class II and co-stimulatory molecules (CD80 and CD86), lacking CD1a, producing suppressive cytokines such as interleukin 10 (IL-10) [28].
Gene_expression (ver exp) of CD1a in CD86 associated with cytokine
14) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.85 Pain Relevance 0.16
Skin biopsy of these lesions shows a characteristic vacuolated histiocytic infiltrate which contains Touton giant cells in 85% of the cases and a characteristic positivity of the lesions to factor XIIIa, CD68, CD163, fascin, and CD14 but negative S100 and CD1 on immunohistochemistry [10].
Neg (negative) Gene_expression (negative) of CD1 in Skin
15) Confidence 0.13 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.21 Pain Relevance 0.16
The neoplastic cells consistently express S-100 protein, and, unlike HS, CD1a [1,5,9].
Gene_expression (express) of CD1a associated with histiocytic sarcoma
16) Confidence 0.12 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 1.06 Pain Relevance 0
It was also shown that MTP affects antigen presentation and is able to regulate CD1a, CD1b and CD1c production, hence supporting the idea that MTP is important in the host response to microbial pathogens.
Gene_expression (production) of CD1a
17) Confidence 0.11 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.07 Pain Relevance 0
Second, a recent study reported a 100% rate of CD1a immunoexpression in PEComas from various sites [81].
Gene_expression (immunoexpression) of CD1a
18) Confidence 0.08 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 1.14 Pain Relevance 0
The author examined 5 ESM (4 epithelioid leiomyomas and 1 epithelioid leiomyosarcoma) diagnosed by WHO criteria [17] and all were negative for CD1a.
Neg (negative) Gene_expression (negative) of CD1a associated with leiomyosarcoma and epithelioid leiomyoma
19) Confidence 0.08 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 1.07 Pain Relevance 0
The interpretation of allergic/atopic predisposition in POEE risk was indicated by our recent observation of elevated leukocyte function asscoiated molecule-1 (LFA-1) expression on leukocytes of at risk patients [18], as LFA-1 expression is increased on leukocytes of atopic children [36].
Gene_expression (expression) of asscoiated molecule-1 in leukocytes associated with pressure and volume under development and hypersensitivity
20) Confidence 0.03 Published 2002 Journal Crit Care Section Body Doc Link PMC125311 Disease Relevance 1.18 Pain Relevance 0.05

General Comments

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