INT83909

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.04
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SERPINA3) nucleus (SERPINA3) intracellular (SERPINA3)
DNA binding (SERPINA3)
Anatomy Link Frequency
globules 4
SERPINA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 86.88 High High
cINOD 2 81.28 Quite High
abdominal pain 2 80.84 Quite High
Inflammation 3 75.00 Quite High
Analgesic 1 58.48 Quite High
Pain 5 34.48 Quite Low
Disease Link Frequency Relevance Heat
Cancer 21 99.86 Very High Very High Very High
Rhinitis 3 98.08 Very High Very High Very High
Recurrence 7 97.24 Very High Very High Very High
Anaplastic Astrocytoma 1 83.16 Quite High
Abdominal Pain 2 80.84 Quite High
Cirrhosis 2 79.36 Quite High
Hepatitis 2 78.60 Quite High
Disease 10 76.20 Quite High
Sarcoma 11 75.00 Quite High
INFLAMMATION 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrophoretic mobility shift and reporter gene assays revealed that tepoxalin exerts its inhibitory effect through the inhibition of nuclear factor kappaB (NF-kappaB), a transcription factor involved in the induction of IL-1, IL-6 and ACT gene expression.
Positive_regulation (induction) of Gene_expression (expression) of ACT
1) Confidence 0.67 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.42 Pain Relevance 0.40
Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.
Positive_regulation (positive) of Gene_expression (staining) of AACT in globules associated with rhinitis and cancer
2) Confidence 0.49 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.87 Pain Relevance 0.08
Immunohistochemical studies showed that the tumor cells expressed strong immunoreactivity for vimentin (VIM) and alpha1-antichymotrypsin (?
Positive_regulation (immunoreactivity) of Gene_expression (expressed) of alpha1-antichymotrypsin associated with cancer
3) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887780 Disease Relevance 0.87 Pain Relevance 0
Immunohistochemical study results showed that the tumor cells were positive for vimentin, alpha-1-antichymotrypsin (AACT) and desmin staining, and negative for alpha-fetoprotein (AFP), and eosinophilic hyaline globules in the cytoplasm of some giant cells were strongly positive for periodic acid-Schiff (PAS) staining.
Positive_regulation (positive) of Gene_expression (staining) of alpha-1-antichymotrypsin in globules associated with rhinitis and cancer
4) Confidence 0.44 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15682496 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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