INT8391

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 5.05
Pain Relevance 14.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
striatum 4
plasma 2
hippocampal formation 2
brain 2
brainstem 2
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 135 100.00 Very High Very High Very High
Enkephalin 33 100.00 Very High Very High Very High
medulla 26 100.00 Very High Very High Very High
gABA 15 100.00 Very High Very High Very High
Ventral tegmentum 11 100.00 Very High Very High Very High
Somatostatin 7 100.00 Very High Very High Very High
Cholecystokinin 7 100.00 Very High Very High Very High
dopamine receptor 2 100.00 Very High Very High Very High
qutenza 84 99.98 Very High Very High Very High
Lasting pain 15 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 68 99.98 Very High Very High Very High
Stress 7 99.98 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 99.48 Very High Very High Very High
Urological Neuroanatomy 46 99.20 Very High Very High Very High
Nociception 67 98.20 Very High Very High Very High
Ganglion Cysts 9 87.80 High High
INFLAMMATION 19 87.40 High High
Necrosis 2 82.48 Quite High
Cancer 2 82.12 Quite High
Body Weight 2 81.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most striking increases in neurotensin mRNA expression were observed 16-17 days after the onset of nociceptive stimuli.
Positive_regulation (increases) of Gene_expression (expression) of neurotensin mRNA associated with nociception
1) Confidence 0.67 Published 1993 Journal Brain Res. Section Abstract Doc Link 8518953 Disease Relevance 1.28 Pain Relevance 0.66
METH injection did not cause further increases in Nts expression on the side of the lesion when compared to the saline-treated 6-OHDA-injected animals (compare SL to ML group).
Neg (not) Positive_regulation (increases) of Gene_expression (expression) of Nts
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.14
Our results showed that a lesion of the nigrostriatal pathway induced the expression of enkephalin, neurotensin, and substance P immunoreactivity in numerous pallidal cell bodies.
Positive_regulation (induced) of Gene_expression (expression) of neurotensin associated with enkephalin and substance p
3) Confidence 0.64 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552872 Disease Relevance 0 Pain Relevance 0.46
The peptidase-resistant derivative of neurotensin, [D-Trp11]neurotensin, has been continuously infused intracerebroventricularly (75 ng/h) with an osmotic minipump for 10 days.
Positive_regulation (derivative) of Gene_expression (resistant) of neurotensin
4) Confidence 0.50 Published 1994 Journal Peptides Section Abstract Doc Link 8008636 Disease Relevance 0.16 Pain Relevance 0.29
Neurotensin also produced a dose-related (0.1-3.3 nmol) increase in dopamine and its metabolites.
Positive_regulation (increase) of Gene_expression (produced) of Neurotensin associated with dopamine
5) Confidence 0.50 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1697899 Disease Relevance 0 Pain Relevance 0.74
The elevation in extracellular dopamine produced by DAMGO, but not by neurotensin, was positively correlated with the increase in motor activity.
Positive_regulation (elevation) of Neg (not) Gene_expression (produced) of neurotensin associated with dopamine
6) Confidence 0.50 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 1697899 Disease Relevance 0 Pain Relevance 0.75
Activation of the VTA dopamine (DA) system may produce reinforcing effects in general because (a) neurotensin is self-administered into the VTA, and injection of neurotensin into the VTA produces CPP and enhances DA release in the nucleus accumbens (NAC), and (b) GABA(A) antagonists are self-administered into the anterior VTA and injections of GABA(A) antagonists into the anterior VTA enhance DA release in the NAC.
Positive_regulation (enhances) of Gene_expression (injection) of neurotensin in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, gaba, dopamine and antagonist
7) Confidence 0.49 Published 1999 Journal Behav. Brain Res. Section Abstract Doc Link 10372570 Disease Relevance 0 Pain Relevance 1.66
Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.
Positive_regulation (caffeine-induced) of Gene_expression (expression) of neurotensin/neuromedin N in striatum associated with enkephalin
8) Confidence 0.49 Published 1997 Journal Eur. J. Neurosci. Section Title Doc Link 9421173 Disease Relevance 0 Pain Relevance 0.10
Involvement of a c-fos-dependent mechanism in caffeine-induced expression of the preprotachykinin A and neurotensin/neuromedin N genes in rat striatum.
Positive_regulation (caffeine-induced) of Gene_expression (expression) of neurotensin/neuromedin N in striatum associated with enkephalin
9) Confidence 0.49 Published 1997 Journal Eur. J. Neurosci. Section Title Doc Link 9421173 Disease Relevance 0 Pain Relevance 0.10
Chronic pain increases brainstem proneurotensin/neuromedin-N mRNA expression: a hybridization-histochemical and immunohistochemical study using three different rat models for chronic nociception.
Positive_regulation (increases) of Gene_expression (expression) of neuromedin-N in brainstem associated with nociception, medulla and lasting pain
10) Confidence 0.49 Published 1993 Journal Brain Res. Section Title Doc Link 8518953 Disease Relevance 1.05 Pain Relevance 0.89
These findings indicate a major distinction between those peptides (vasoactive intestinal polypeptide, cholecystokinin-octapeptide, somatostatin, neurotensin) which are found in cell bodies intrinsic to the hippocampal formation and those peptides (substance P, methionine-enkephalin) which are found only in hippocampal afferents.
Positive_regulation (distinction) of Gene_expression (peptides) of neurotensin in hippocampal formation associated with somatostatin, enkephalin, cholecystokinin and substance p
11) Confidence 0.49 Published 1984 Journal Neuroscience Section Abstract Doc Link 6200800 Disease Relevance 0 Pain Relevance 0.77
Irradiation significantly increased the levels of neurotensin, Il-1beta, and TNF-alpha in both layers.
Positive_regulation (increased) of Gene_expression (levels) of neurotensin
12) Confidence 0.40 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 12741457 Disease Relevance 0.16 Pain Relevance 0.84
This instance could explain why IG administration of capsaicin induces comparatively little expression of c-fos mRNA in the NTS.
Positive_regulation (induces) of Gene_expression (expression) of NTS associated with qutenza
13) Confidence 0.39 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.25 Pain Relevance 0.91
SL327, an inhibitor of ERK activation, at doses which reduced the hyperactive pERK(1/2) levels, did not attenuated the rise in pCREB and TH immunoreactivity or plasma corticosterone secretion during morphine withdrawal, indicating that ERK kinase/ERK pathway was not directly needed for either activation of CREB and TH expression in the NTS or HPA axis hyperactivity.
Positive_regulation (activation) of Gene_expression (expression) of NTS in plasma associated with attention deficit hyperactivity disorder, withdrawal and morphine
14) Confidence 0.30 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19545278 Disease Relevance 0.22 Pain Relevance 1.22
Cold water swim stress increases the expression of neurotensin mRNA in the lateral hypothalamus and medial preoptic regions of the rat brain.
Positive_regulation (increases) of Gene_expression (expression) of neurotensin mRNA in lateral associated with stress
15) Confidence 0.30 Published 2001 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11165381 Disease Relevance 0.68 Pain Relevance 0.79
Administration of monosodium glutamate (MSG) during the neonatal period in rats produced differential effects on the contents of various neuropeptides in the hypothalamus: beta-endorphin (beta-E) level was reduced by 70% while substance P (SP), neurotensin (NT) and Met5-enkephalin (ME) levels were not significantly changed (ME content of male rats was slightly reduced).
Neg (not) Positive_regulation (changed) of Gene_expression (levels) of neurotensin in hypothalamus associated with glutamate, neuropeptide, enkephalin and substance p
16) Confidence 0.28 Published 1981 Journal Regul. Pept. Section Abstract Doc Link 6171018 Disease Relevance 0 Pain Relevance 1.00
Activation of the arterial baroreceptors induces expression of the proto-oncogene c-fos in the nucleus tractus solitarii (NTS), the terminal site of baroreceptor afferents in the medulla oblongata.
Positive_regulation (induces) of Gene_expression (expression) of NTS in medulla oblongata associated with medulla
17) Confidence 0.28 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14742673 Disease Relevance 0.07 Pain Relevance 0.13
The increase in the extracellular levels of GABA and ACh produced by 0.5 microM neurotensin in the hippocampus reached a maximum of about 310% for GABA and 250% for ACh.
Positive_regulation (increase) of Gene_expression (produced) of neurotensin in hippocampus associated with gaba and hippocampus
18) Confidence 0.27 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9840224 Disease Relevance 0 Pain Relevance 0.97
Antipsychotic drugs did not alter expression of D1R, D2R or D3R receptor mRNAs but elevated neurotensin and proenkephalin expression in both groups of rats; patterns of changes were dependent on the duration of treatment and brain area examined.
Neg (not) Positive_regulation (elevated) of Gene_expression (expression) of neurotensin in brain
19) Confidence 0.23 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.16 Pain Relevance 0.22
We used in situ hybridization histochemistry to assess expression of dopamine receptors (D1R, D2R and D3R), neurotensin, proenkephalin and glutamate decarboxylase-67 (GAD67) in the prefrontal cortex, striatum, and/or nucleus accumbens in adult rats with neonatal ventral hippocampal (VH) lesions and in control animals after acute and chronic treatment with antipsychotic drugs clozapine and haloperidol.
Positive_regulation (assess) of Gene_expression (expression) of neurotensin in prefrontal associated with nucleus accumbens, glutamate and dopamine receptor
20) Confidence 0.23 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12887421 Disease Relevance 0.14 Pain Relevance 0.22

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