INT83911

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Context Info
Confidence 0.43
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 5.20
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINA1) extracellular region (SERPINA1) proteinaceous extracellular matrix (SERPINA1)
Anatomy Link Frequency
plasma 4
Skin 2
astrocytes 2
SERPINA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 21 99.68 Very High Very High Very High
spinal inflammation 172 97.52 Very High Very High Very High
cINOD 11 94.08 High High
Analgesic 1 92.44 High High
cytokine 7 87.40 High High
rheumatoid arthritis 76 73.44 Quite High
Osteoarthritis 72 69.88 Quite High
corticosteroid 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 8 100.00 Very High Very High Very High
INFLAMMATION 27 99.68 Very High Very High Very High
Disease 57 98.32 Very High Very High Very High
Low Back Pain 170 97.52 Very High Very High Very High
Panniculitis 6 96.16 Very High Very High Very High
Arthritis 4 95.56 Very High Very High Very High
Asthma 2 94.88 High High
Bronchitis 1 94.44 High High
Bronchiectasis 1 93.20 High High
Pulmonary Disease 15 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Skin disorders and alpha-1-antitrypsin deficiency
Negative_regulation (disorders) of Gene_expression (deficiency) of alpha-1-antitrypsin in Skin
1) Confidence 0.43 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2441617 Disease Relevance 1.17 Pain Relevance 0.08
Additionally, a significantly increased expression level of the alpha-1-antitrypsin (A1AT) precursor, which is an important plasma inhibitor of serine proteases, was detected in the synovial tissues of AS patients using a proteomic approach.
Negative_regulation (inhibitor) of Gene_expression (expression) of A1AT in plasma associated with spinal inflammation and alpha-1-antitrypsin deficiency
2) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.76 Pain Relevance 0.79
Additionally, a significantly increased expression level of the alpha-1-antitrypsin (A1AT) precursor, which is an important plasma inhibitor of serine proteases, was detected in the synovial tissues of AS patients using a proteomic approach.
Negative_regulation (inhibitor) of Gene_expression (expression) of antitrypsin in plasma associated with spinal inflammation and alpha-1-antitrypsin deficiency
3) Confidence 0.11 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3012668 Disease Relevance 1.76 Pain Relevance 0.79
The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha.
Negative_regulation (inhibits) of Gene_expression (synthesis) of alpha1-anti-chymotrypsin in astrocytes associated with inflammation
4) Confidence 0.01 Published 1999 Journal Neuropharmacology Section Title Doc Link 10471086 Disease Relevance 0.50 Pain Relevance 0.42

General Comments

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