INT8392

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Context Info
Confidence 0.54
First Reported 1991
Last Reported 2010
Negated 1
Speculated 7
Reported most in Abstract
Documents 37
Total Number 44
Disease Relevance 6.90
Pain Relevance 19.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Qrfp) cellular_component (Qrfp)
Anatomy Link Frequency
striatum 12
neurons 8
nucleus 6
nucleus pulposus 6
astrocyte 6
Qrfp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 236 100.00 Very High Very High Very High
cytokine 89 100.00 Very High Very High Very High
Enkephalin 65 100.00 Very High Very High Very High
agonist 31 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
antagonist 20 99.98 Very High Very High Very High
Inflammation 17 99.98 Very High Very High Very High
Peripheral nerve injury 4 99.92 Very High Very High Very High
cocaine 6 99.82 Very High Very High Very High
Immobilon 6 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 15 100.00 Very High Very High Very High
INFLAMMATION 13 99.98 Very High Very High Very High
Nervous System Injury 8 99.92 Very High Very High Very High
Volume Depletion And Dehydration 9 99.82 Very High Very High Very High
Intervertebral Disk Degeneration 20 99.68 Very High Very High Very High
Ganglion Cysts 106 99.56 Very High Very High Very High
Stress 4 97.76 Very High Very High Very High
Arthritis 3 97.40 Very High Very High Very High
Nociception 35 96.88 Very High Very High Very High
Neurogenic Inflammation 3 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have explored the effect of histamine H3-receptor ligands on the regulation of neuropeptide mRNA expression in the striatum by using in situ hybridization performed with proenkephalin, prodynorphin, substance P and proneurotensin riboprobes.
Regulation (regulation) of Gene_expression (expression) of neuropeptide mRNA in striatum associated with neuropeptide and substance p
1) Confidence 0.54 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.43
In agreement with some data of the literature, our results indicate that the bed nucleus of the stria terminalis plays an important role in the regulation of neuropeptide genes expression in certain regions of the limbic system.
Regulation (role) of Gene_expression (expression) of neuropeptide in nucleus associated with neuropeptide and limbic system
2) Confidence 0.54 Published 1996 Journal Neuroscience Section Abstract Doc Link 8843088 Disease Relevance 0 Pain Relevance 0.36
Rats were infused first in either right or left RFA (chosen randomly), and then infused in the contralateral location; consequently, the contralateral infusion was completed 4?
Regulation (infused) of Gene_expression (left) of RFA
3) Confidence 0.33 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2965050 Disease Relevance 0 Pain Relevance 0.15
To determine if effects of RFA inactivation are sensitive to delay duration, rats were trained to perform a two-delay version of the task, with stimuli presented at either 0.6 or 1.2?
Spec (determine) Regulation (effects) of Gene_expression (inactivation) of RFA
4) Confidence 0.33 Published 2010 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2965050 Disease Relevance 0 Pain Relevance 0
Therefore, muscarinic cholinergic regulation of basal and stimulated expression of neuropeptide mRNA is processed within the striatum.
Regulation (regulation) of Gene_expression (expression) of neuropeptide mRNA in striatum associated with neuropeptide
5) Confidence 0.26 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067445 Disease Relevance 0 Pain Relevance 0.33
In agreement with some data of the literature, our results indicate that the bed nucleus of the stria terminalis plays an important role in the regulation of neuropeptide genes expression in certain regions of the limbic system.
Regulation (regulation) of Gene_expression (expression) of neuropeptide in nucleus associated with neuropeptide and limbic system
6) Confidence 0.24 Published 1996 Journal Neuroscience Section Abstract Doc Link 8843088 Disease Relevance 0 Pain Relevance 0.36
The present study examines dopaminergic regulation of neuropeptide gene expression within a relatively poorly characterized population of cells, the preproenkephalin (PPE) mRNA containing neurons of the globus pallidus (GP).
Spec (examines) Regulation (regulation) of Gene_expression (expression) of neuropeptide in globus pallidus associated with neuropeptide
7) Confidence 0.22 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10350647 Disease Relevance 0 Pain Relevance 0.12
Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum.
Regulation (effects) of Gene_expression (expression) of neuropeptide mRNA in striatum associated with antagonist, neuropeptide, agonist and enkephalin
8) Confidence 0.21 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.84
However, ciproxifan strongly and differentially modulated the effect of a single administration of 3 mg/kg methamphetamine on neuropeptide mRNA expression.
Regulation (effect) of Gene_expression (expression) of neuropeptide mRNA associated with neuropeptide
9) Confidence 0.21 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.55
Ciproxifan, a histamine H3-receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum.
Regulation (modulates) of Gene_expression (expression) of neuropeptide mRNA in striatum associated with antagonist, neuropeptide, agonist and enkephalin
10) Confidence 0.21 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.84
However, ciproxifan strongly and differentially modulated the effect of a single administration of 3 mg/kg methamphetamine on neuropeptide mRNA expression.
Regulation (modulated) of Gene_expression (expression) of neuropeptide mRNA associated with neuropeptide
11) Confidence 0.21 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12542667 Disease Relevance 0 Pain Relevance 0.55
However, before use of these slice explant cultures as experimental models for physiological and pharmacological studies on the regulation of neuropeptide gene expression, it is first necessary to evaluate their characteristics in defined (e.g. serum free) media and to control for the spontaneous electrical and synaptic activity of neurons in these cultures.
Regulation (regulation) of Gene_expression (expression) of neuropeptide in neurons associated with neuropeptide
12) Confidence 0.19 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1758575 Disease Relevance 0 Pain Relevance 0.17
The results provide evidence of a novel mechanism which may provide an additional level of control in the regulation of neuropeptide gene expression.
Regulation (regulation) of Gene_expression (expression) of neuropeptide associated with neuropeptide
13) Confidence 0.17 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8247343 Disease Relevance 0.07 Pain Relevance 0.09
Considered together with the effects of adrenalectomy on peptide colocalization, our results suggest the existence of several phenotypically distinct sets of neurons within the medial parvicellular division of the paraventricular nucleus, each characterized by its ability to regulate the expression of neuropeptide genes in a stimulus-specific manner.
Regulation (regulate) of Gene_expression (expression) of neuropeptide in nucleus associated with neuropeptide
14) Confidence 0.17 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7721997 Disease Relevance 0.09 Pain Relevance 0.05
These data indicate that both mu and delta receptor subtypes differentially regulate amphetamine-induced behavior and neuropeptide gene expression in the rat striatum.
Regulation (regulate) of Gene_expression (expression) of neuropeptide in striatum associated with neuropeptide
15) Confidence 0.16 Published 2003 Journal Neuroscience Section Abstract Doc Link 14521997 Disease Relevance 0.07 Pain Relevance 0.53
Acute and subchronic effects of dopamine agonists on neuropeptide gene expression in the rat striatum.
Regulation (effects) of Gene_expression (expression) of neuropeptide in striatum associated with dopamine, neuropeptide, agonist and enkephalin
16) Confidence 0.14 Published 1995 Journal Neuropeptides Section Title Doc Link 7477761 Disease Relevance 0 Pain Relevance 0.93
Intrastriatal injection of a muscarinic receptor agonist and antagonist regulates striatal neuropeptide mRNA expression in normal and amphetamine-treated rats.
Regulation (regulates) of Gene_expression (expression) of neuropeptide mRNA associated with antagonist, neuropeptide, agonist and enkephalin
17) Confidence 0.14 Published 1997 Journal Brain Res. Section Title Doc Link 9067445 Disease Relevance 0 Pain Relevance 0.66
Because of the potential importance of these interactions in injured brain, we have examined the role of two different receptors in the regulation of astrocyte neuropeptide synthesis.
Spec (examined) Regulation (role) of Gene_expression (synthesis) of neuropeptide in astrocyte associated with neuropeptide
18) Confidence 0.13 Published 1994 Journal Glia Section Abstract Doc Link 7927646 Disease Relevance 0 Pain Relevance 0.63
Receptor-mediated regulation of neuropeptide gene expression in astrocytes.
Regulation (regulation) of Gene_expression (expression) of neuropeptide in astrocytes associated with neuropeptide and immobilon
19) Confidence 0.13 Published 1994 Journal Glia Section Title Doc Link 7927646 Disease Relevance 0 Pain Relevance 0.91
Regulation of neuropeptide mRNA expression in the basal ganglia by intrastriatal and intranigral transplants in the rat Parkinson model.
Regulation (Regulation) of Gene_expression (expression) of neuropeptide mRNA in basal ganglia associated with neuropeptide and enkephalin
20) Confidence 0.12 Published 2003 Journal Neuroscience Section Title Doc Link 12732251 Disease Relevance 0.06 Pain Relevance 0.61

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