INT83946

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.33
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Vcam1) cell adhesion (Vcam1) plasma membrane (Vcam1)
Anatomy Link Frequency
Lung 1
Vcam1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 41 100.00 Very High Very High Very High
Angina 9 92.56 High High
cytokine 23 77.80 Quite High
chemokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 43 100.00 Very High Very High Very High
Adhesions 38 100.00 Very High Very High Very High
Hypoxia 87 96.56 Very High Very High Very High
Myocardial Infarction 5 93.52 High High
Cardiovascular Disease 5 92.80 High High
Cv General 3 Under Development 5 92.56 High High
Stable Angina Pectoris 4 91.52 High High
Coronary Artery Disease 4 86.08 High High
Atherosclerosis 43 81.16 Quite High
Targeted Disruption 22 77.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mean levels of mRNA for CD44, VCAM-1, MCP-1, and Cox-2, in fact, were elevated in 6-weeks old apoE?
Transcription (levels) of VCAM-1
1) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.46 Pain Relevance 0.04
Lung mRNA levels of the inflammatory biomarkers VCAM-1, ICAM-1, and MCP-1, as well as of endothelin-1 (ET-1) were considerably higher after hypoxia than after normoxia, with no differences between IL-6-/- and wild-type mice (Figure 5).


Transcription (levels) of VCAM-1 in Lung associated with inflammation and hypoxia
2) Confidence 0.27 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.93 Pain Relevance 0.09
To investigate the pathogenesis of this condition, a quantitative reverse transcriptase polymerase chain reaction was used to determine relative levels of mRNA for interleukin (IL)-1beta, IL-6, IL-8, transforming growth factor beta (TGF-beta), intercellular adhesion molecule (ICAM)-1, E-selectin and vascular cell adhesion molecule (VCAM)-1 using directional coronary atherectomy (DCA) specimens.
Spec (determine) Transcription (levels) of VCAM associated with adhesions
3) Confidence 0.02 Published 1999 Journal Jpn. Circ. J. Section Abstract Doc Link 10475771 Disease Relevance 1.95 Pain Relevance 0.81

General Comments

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