INT83950

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Context Info
Confidence 0.59
First Reported 1999
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 31
Total Number 34
Disease Relevance 27.76
Pain Relevance 13.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr1) plasma membrane (Cxcr1) signal transducer activity (Cxcr1)
Anatomy Link Frequency
macrophages 4
neutrophils 4
liver 3
monocyte 2
dendritic cells 1
Cxcr1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 848 100.00 Very High Very High Very High
Inflammation 574 100.00 Very High Very High Very High
Osteoarthritis 550 99.88 Very High Very High Very High
rheumatoid arthritis 1235 99.56 Very High Very High Very High
agonist 109 99.50 Very High Very High Very High
Nicotine 160 99.40 Very High Very High Very High
Dextromethorphan 14 99.38 Very High Very High Very High
Paracetamol 8 96.00 Very High Very High Very High
antagonist 14 92.20 High High
cytokine 505 90.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 646 100.00 Very High Very High Very High
Osteoarthritis 550 99.88 Very High Very High Very High
Infection 104 99.82 Very High Very High Very High
Breast Cancer 34 99.68 Very High Very High Very High
Rheumatoid Arthritis 1235 99.56 Very High Very High Very High
Injury 645 99.50 Very High Very High Very High
Apoptosis 58 99.36 Very High Very High Very High
Adhesions 191 98.64 Very High Very High Very High
Inflammatory Bowel Disease 40 98.60 Very High Very High Very High
Disease 232 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the protein level, we observed abundant expression of CXCR1 and CXCR3 in RA synovial tissue.
Gene_expression (expression) of CXCR1 associated with rheumatoid arthritis
1) Confidence 0.59 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.67 Pain Relevance 0.90
Thus, we identified CXCR1 protein expression on synovial macrophages in RA as well as in OA patients.
Gene_expression (expression) of CXCR1 protein in macrophages associated with rheumatoid arthritis and osteoarthritis
2) Confidence 0.59 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.60 Pain Relevance 0.86
The CXCR1 protein was weakly expressed on CD68+ macrophages in a diffuse manner and showed a consistent distribution pattern within all sections of RA patients (data not shown).
Gene_expression (expressed) of CXCR1 protein in macrophages associated with rheumatoid arthritis
3) Confidence 0.59 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.71 Pain Relevance 0.36
Thus, in agreement with differential mRNA expression, CXCR1 and CXCR3 proteins were expressed in synovial tissue from patients with RA at higher levels than in tissues from patients with OA.


Gene_expression (expressed) of CXCR1 associated with rheumatoid arthritis and osteoarthritis
4) Confidence 0.59 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.52 Pain Relevance 0.67
In this respect, our report confirms increased CXCR1 protein expression on synovial macrophages, which has been considered to cause a chemotactic influx of mononuclear cells into RA synovial tissue in response to CXCL8 (IL-8) [33,34].
Gene_expression (expression) of CXCR1 protein in mononuclear cells associated with rheumatoid arthritis
5) Confidence 0.59 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.62 Pain Relevance 0.87
Various studies have shown that mouse does code for the CXCR1 receptor as evident from mRNA expression, but at this time, there is no evidence for expression of a functional CXCR1 receptor in mouse neutrophils [24]–[26].
Gene_expression (expression) of CXCR1 receptor in neutrophils
6) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.17 Pain Relevance 0.07
To better understand the role of monomers and dimers in receptor activation, we recently characterized the functional responses of our trapped monomer, trapped dimer, and WT in mammalian cells individually expressing CXCR1 or CXCR2 [13].
Gene_expression (expressing) of CXCR1
7) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.06
All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).
Gene_expression (antibodies) of CXCR1 in fibroblast
8) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.11 Pain Relevance 0.06
Staining for CXCR1 (P < 0.05) and CXCR3 (P < 0.01) revealed a higher level of expression for each protein in RA than in OA synovial tissue (Fig. 3b).
Gene_expression (Staining) of CXCR1 associated with rheumatoid arthritis and osteoarthritis
9) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.49 Pain Relevance 0.66
Elevated protein levels in RA synovial tissue were detected for CXCR1 and CXCR3 by Western blotting.
Gene_expression (detected) of CXCR1 associated with rheumatoid arthritis
10) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Abstract Doc Link PMC193722 Disease Relevance 1.51 Pain Relevance 0.68
Next, we investigated cellular distribution of the CXCR1, CXCR2, and CXCR3 proteins.
Spec (investigated) Gene_expression (distribution) of CXCR1
11) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.30 Pain Relevance 0.58
Distribution and cellular assignment of CXCR1, CXCR2, and CXCR3 to different cellular subsets in RA and OA tissues
Gene_expression (Distribution) of CXCR1 associated with rheumatoid arthritis and osteoarthritis
12) Confidence 0.51 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.36 Pain Relevance 0.60
Various studies have shown that mouse does code for the CXCR1 receptor as evident from mRNA expression, but at this time, there is no evidence for expression of a functional CXCR1 receptor in mouse neutrophils [24]–[26].
Gene_expression (expression) of CXCR1 receptor in neutrophils
13) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.17 Pain Relevance 0.07
Protein levels of CXCR1, CXCR2, and CXCR3 in RA versus OA synovial tissue were examined by Western blotting of tissue extracts.
Spec (examined) Gene_expression (levels) of CXCR1 associated with rheumatoid arthritis and osteoarthritis
14) Confidence 0.46 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.20 Pain Relevance 0.10
Equilibrium competition receptor binding assays were performed using CHO/CXCR1 transfectants using 125I-CXCL8, as previously described (39).
Gene_expression (transfectants) of CXCR1
15) Confidence 0.36 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.07 Pain Relevance 0
Only vascular endothelial growth factor (VEGF) and the CXC chemokine receptor 4 (CXCR4), of 16 genes tested, were additively increased by both TGF-?
Gene_expression (Only) of CXC chemokine receptor 4 associated with chemokine
16) Confidence 0.31 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731927 Disease Relevance 1.71 Pain Relevance 0.19
However, AdMIP-2 infection in mice lacking the CXC chemokine receptor that binds MIP-2, CXCR2, did not attenuate any of the markers of liver injury after adenovirus and acetaminophen challenge.
Neg (lacking) Gene_expression (lacking) of CXC chemokine receptor in liver associated with chemokine, paracetamol, injury and infection
17) Confidence 0.29 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10476217 Disease Relevance 0.98 Pain Relevance 0.71
Real-time RT-PCR analysis revealed that DM administration suppressed the expression of a variety of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intercellular adhesion molecular-1 and interleukin-6.
Gene_expression (expression) of CXC chemokine in macrophage associated with chemokine, inflammation, dextromethorphan and adhesions
18) Confidence 0.21 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15627475 Disease Relevance 1.06 Pain Relevance 0.79
Real-time reverse transcription-polymerase chain reaction analysis revealed that V-PYRRO/NO administration suppressed the expression of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intracellular adhesion molecular-1, and interleukin-6.
Gene_expression (expression) of CXC chemokine in macrophage associated with chemokine, inflammation and adhesions
19) Confidence 0.16 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15010501 Disease Relevance 0.74 Pain Relevance 0.25
Iho et al. showed that nicotine induces human neutrophils to produce IL-8 (CXC chemokine) through the production of ROS and subsequent activation of NF-kB, with no effect on monocytes [43].
Neg (no) Gene_expression (produce) of CXC chemokine in monocytes associated with chemokine and nicotine
20) Confidence 0.14 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.47 Pain Relevance 0.43

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