INT83951

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Context Info
Confidence 0.71
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 31
Total Number 36
Disease Relevance 19.36
Pain Relevance 7.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
lung 6
neutrophils 6
macrophages 1
hepatocytes 1
liver 1
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 952 100.00 Very High Very High Very High
Osteoarthritis 250 99.88 Very High Very High Very High
member 8 18 99.70 Very High Very High Very High
rheumatoid arthritis 511 99.68 Very High Very High Very High
Inflammation 1102 99.60 Very High Very High Very High
Paracetamol 12 97.00 Very High Very High Very High
Arthritis 52 95.12 Very High Very High Very High
fibrosis 142 88.00 High High
Inflammatory response 57 71.68 Quite High
cytokine 285 18.68 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 250 99.88 Very High Very High Very High
Infection 94 99.82 Very High Very High Very High
Rheumatoid Arthritis 536 99.68 Very High Very High Very High
Immunization 17 99.68 Very High Very High Very High
INFLAMMATION 1089 99.60 Very High Very High Very High
Lung Injury 642 99.52 Very High Very High Very High
Disease 236 99.16 Very High Very High Very High
Pneumonia 197 99.12 Very High Very High Very High
Hyperoxia 21 98.86 Very High Very High Very High
Injury 223 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of CXCR2 mRNA paralleled its ligand expression, neutrophil sequestration, and lung injury at 72 h following dsRNA treatment (Figs. 2, 3, and 5).


Gene_expression (expression) of CXCR2 mRNA in neutrophil associated with lung injury
1) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.41 Pain Relevance 0.08
CT (CXCR2 expression from ssRNA-treated controls normalized to endogenous 18S).
Gene_expression (expression) of CXCR2
2) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.14 Pain Relevance 0
Other studies of inflammatory diseases, such as ventilator-induced lung injury, pneumonia, and hyperoxia-induced lung injury have demonstrated the importance of CXCR2 expression and its role in neutrophil recruitment during the pathogenesis of these diseases [24,40,41,51].
Gene_expression (expression) of CXCR2 in lung associated with lung injury, inflammation, hyperoxia, pneumonia and disease
3) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.22 Pain Relevance 0.21
CT (CXCR2 expression from dsRNA-treated animals normalized to endogenous 18S)-?
Gene_expression (expression) of CXCR2
4) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.12 Pain Relevance 0
Lung homogenates from dsRNA-treated animals had significantly increased CXCR2 mRNA expression as compared to controls (Fig. 6).
Gene_expression (expression) of CXCR2 mRNA in Lung
5) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.39 Pain Relevance 0.08
Furthermore, expression of CXCR2 mRNA was similarly increased in parallel to the production of both CXCL1 and CXCL2/3 ligands and neutrophil sequestration during dsRNA-induced lung inflammation.
Gene_expression (expression) of CXCR2 mRNA in lung associated with inflammation and pneumonia
6) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.07 Pain Relevance 0.20
The finding of increased levels of KC/CXCL1 and MIP-2/CXCL2/3 associated with dsRNA-induced neutrophil sequestration and lung injury led us to evaluate the expression of CXCR2 mRNA in the lungs of these animals.
Gene_expression (expression) of CXCR2 mRNA in lung associated with lung injury
7) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.31 Pain Relevance 0.11
DsRNA increases CXCR2 expression in lungs
Gene_expression (expression) of CXCR2 in lungs
8) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.19 Pain Relevance 0.15
The following is an example for comparing CXCR2 expression from dsRNA-treated animals and ssRNA-treated controls.
Gene_expression (expression) of CXCR2
9) Confidence 0.71 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.05 Pain Relevance 0
The therapeutic effect of IP-10 was associated with a marked increase in CXCR2 expression on hepatocytes.
Gene_expression (expression) of CXCR2 in hepatocytes
10) Confidence 0.71 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11739529 Disease Relevance 0.22 Pain Relevance 0.45
Collectively, these studies demonstrate that augmented levels of CXCR2 ligands are important in the recruitment of neutrophils during the pathogenesis of inflammatory diseases and suggest that the interaction between CXCR2 ligands and CXCR2 may be pivotal in the recruitment of neutrophils to the lung during dsRNA-induced lung injury.
Gene_expression (ligands) of CXCR2 in neutrophils associated with lung injury, inflammation and disease
11) Confidence 0.62 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.22 Pain Relevance 0.19
Collectively, these studies demonstrate that augmented levels of CXCR2 ligands are important in the recruitment of neutrophils during the pathogenesis of inflammatory diseases and suggest that the interaction between CXCR2 ligands and CXCR2 may be pivotal in the recruitment of neutrophils to the lung during dsRNA-induced lung injury.
Gene_expression (ligands) of CXCR2 in neutrophils associated with lung injury, inflammation and disease
12) Confidence 0.62 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.22 Pain Relevance 0.19
To better understand the role of monomers and dimers in receptor activation, we recently characterized the functional responses of our trapped monomer, trapped dimer, and WT in mammalian cells individually expressing CXCR1 or CXCR2 [13].
Gene_expression (expressing) of CXCR2
13) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.06
Unlike human neutrophils that express both receptors, mouse neutrophils seem to express only the CXCR2 receptor.
Gene_expression (express) of CXCR2 in neutrophils
14) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.14 Pain Relevance 0.04
All share considerable sequence homology, have the characteristic ELR motif in the N-terminus, and show robust in vitro activity to both human and mouse CXCR2 expressed in mammalian cell lines.
Gene_expression (expressed) of CXCR2
15) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.23 Pain Relevance 0.13
To understand the mechanisms underlying how monomers and dimers mediate recruitment, we measured the chemotactic activity of our trapped monomer, dimer, and the WT for CXCR2 expressed in HL60 cells using a microfluidic chamber that allows control of both the steepness of the chemokine gradient and protein concentration [18] (Figures 7A–B; supplemental Videos S1 and S2).
Gene_expression (expressed) of CXCR2 associated with chemokine
16) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0.25 Pain Relevance 0.20
Expression of CXCR2 ligands and CXCR2 paralleled neutrophil recruitment to the lung.
Gene_expression (Expression) of CXCR2 in neutrophil
17) Confidence 0.55 Published 2005 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1156932 Disease Relevance 0.63 Pain Relevance 0.09
In this study, we hypothesized that the interaction between CXCR2 and ELR-positive CXC chemokines expressed during dsRNA-induced lung inflammation is critical in mediating neutrophil recruitment, a pivotal process required for dsRNA induced lung injury in viral infections.
Gene_expression (expressed) of CXCR2 in lung associated with lung injury, chemokine, inflammation, viral infection and pneumonia
18) Confidence 0.55 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.70 Pain Relevance 0.43
Expression of CXCR2 ligands and CXCR2 paralleled neutrophil recruitment to the lung.
Gene_expression (Expression) of CXCR2 in neutrophil
19) Confidence 0.55 Published 2005 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1156932 Disease Relevance 0.63 Pain Relevance 0.09
Levels of CXCR2 chemokine ligands at earlier timepoints showed only a small increase (two-fold) in the induction of KC/CXCL1 and MIP-2/CXCL2/3 as early as 4 h following dsRNA-exposure (data not shown), but the maximal increase (>ten-fold for KC/CXCL1 and >four-fold for MIP-2/CXCL2/3) occurred at 72 h following dsRNA-exposure.


Gene_expression (Levels) of CXCR2 associated with chemokine
20) Confidence 0.55 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.12 Pain Relevance 0.16

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