INT83952

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 46
Disease Relevance 22.38
Pain Relevance 6.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) extracellular region (Cxadr) cell adhesion (Cxadr)
mitochondrion organization (Cxadr) plasma membrane (Cxadr) nucleus (Cxadr)
Anatomy Link Frequency
CAR 27
striatum 1
brain 1
shaft 1
kidney 1
Cxadr (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 58 99.52 Very High Very High Very High
Dopamine 414 99.40 Very High Very High Very High
midbrain 69 99.36 Very High Very High Very High
Paracetamol 8 99.36 Very High Very High Very High
Substantia nigra 414 99.28 Very High Very High Very High
imagery 115 97.48 Very High Very High Very High
Demyelination 4 96.68 Very High Very High Very High
Inflammation 89 94.80 High High
chemokine 9 93.80 High High
Central nervous system 207 91.96 High High
Disease Link Frequency Relevance Heat
Infection 167 100.00 Very High Very High Very High
Targeted Disruption 1429 99.98 Very High Very High Very High
Cancer 423 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 36 99.64 Very High Very High Very High
Embryonic Lethality 24 99.52 Very High Very High Very High
Injury 11 98.32 Very High Very High Very High
Arrhythmia Under Development 228 97.72 Very High Very High Very High
Premature Birth 102 97.64 Very High Very High Very High
Pressure And Volume Under Development 24 96.72 Very High Very High Very High
Demyelinating Disease 4 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased CXADR expression on the demyelinated axons facilitated axoplasmic viral entry.
Gene_expression (expression) of CXADR
1) Confidence 0.75 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20623527 Disease Relevance 0.69 Pain Relevance 0.62
Primary antibodies used against CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), ?
Gene_expression (used) of CAR in CAR
2) Confidence 0.64 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0 Pain Relevance 0
Trophoblasts express the coxsackievirus and adenovirus receptor (CAR).
Gene_expression (express) of CAR in CAR
3) Confidence 0.58 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 1.13 Pain Relevance 0.04
Excision of exon 1, which contains the transcription and translation start, affects the expression of any CAR isoform, whereas the tight control of recombination by tamoxifen eliminates developmental effects that might arise from the embryonic loss of CAR expression.
Gene_expression (expression) of CAR in CAR
4) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.69 Pain Relevance 0
We have reduced CAR expression to <20% of control levels at embryonic day (E) 11.5 (Fig. 1 C), which resulted in early lethality between E11.5 and 12.5 (Table I) and resorption from E13.5 (Fig. 1 B).
Gene_expression (expression) of CAR in CAR
5) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.57 Pain Relevance 0
This indicates that CAR KO cardiomyocytes, unlike AV nodal cells are not limited by GAP junction activity, a feature which could derive both from altered expression of connexins and differential localization of CAR between the cell types (Fig. 3).
Gene_expression (expression) of CAR in cardiomyocytes associated with targeted disruption
6) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.95 Pain Relevance 0.04
This includes reduced expression of ZO-1, an adaptor protein that binds both CAR and connexins (Fig. 6 A) (8, 21).
Gene_expression (expression) of CAR in CAR
7) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.45 Pain Relevance 0
Excision of exon 1, which contains the transcription and translation start, affects the expression of any CAR isoform, whereas the tight control of recombination by tamoxifen eliminates developmental effects that might arise from the embryonic loss of CAR expression.
Gene_expression (expression) of CAR in CAR
8) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.73 Pain Relevance 0
To find a morphological correlate of the AV block and verify expression of CAR in AV nodal cells, we used various marker proteins to identify the AV node (Fig. 3) and documented differential localization of CAR in cardiomyocytes versus AV nodal cells (Fig. 3, E and F).
Gene_expression (expression) of CAR in AV node
9) Confidence 0.57 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.81 Pain Relevance 0.08
To efficiently produce surviving heart-specific CAR KO animals and generate an adult KO model without a potentially complicating developmental phenotype, we restricted our analysis to the inducible heart-specific KO.
Gene_expression (produce) of CAR in CAR associated with targeted disruption
10) Confidence 0.55 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 1.17 Pain Relevance 0
The primary antibodies used were the following: rat anti-HCN4 (Abcam) and anti-CAR (rabbit polyclonal, raised against the Fc fusion protein containing the CA extracellular domain), anti-CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), anti–N-cadherin (mouse monoclonal; Invitrogen), anti-Cx43 (mouse monoclonal; Invitrogen), and anti–?
Gene_expression (following) of anti-CAR in CAR
11) Confidence 0.55 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.08 Pain Relevance 0.04
The primary antibodies used were the following: rat anti-HCN4 (Abcam) and anti-CAR (rabbit polyclonal, raised against the Fc fusion protein containing the CA extracellular domain), anti-CAR (rabbit polyclonal; Santa Cruz Biotechnology, Inc.), anti–N-cadherin (mouse monoclonal; Invitrogen), anti-Cx43 (mouse monoclonal; Invitrogen), and anti–?
Gene_expression (following) of anti-CAR in CAR
12) Confidence 0.55 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.08 Pain Relevance 0.04
Unexpectedly, our heart-specific KO of CAR exon 1 was 100% lethal using the identical ?
Gene_expression (exon) of CAR in CAR associated with targeted disruption
13) Confidence 0.55 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 1.01 Pain Relevance 0
It will be important to investigate such tropism-modified Ads to determine whether they can provide enhanced gene delivery to SNc dopamine neurons in wild-type animals expressing natively low levels of CAR, perhaps through other proteins present at post-synaptic sites.
Gene_expression (expressing) of CAR in CAR associated with dopamine
14) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.17 Pain Relevance 0.16
Transgenic mice express the human CAR gene lacking the cytoplasmic tail, under control of the human ubiquitin-C promoter, allowing hCAR to be expressed in a variety of tissues including the liver, kidney, heart, lungs, brain, and muscle [27].
Gene_expression (express) of CAR in kidney associated with targeted disruption
15) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.19 Pain Relevance 0.24
Here we achieved increased gene delivery by transgenic overexpression of CAR, a strategy that is suitable only for establishing proof-of-concept in animal models.
Gene_expression (overexpression) of CAR in CAR associated with targeted disruption
16) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.17 Pain Relevance 0.15
In the context of the design of gene therapy strategies, induction of CAR expression is probably not feasible, but development of Ad viruses with modified tropism is a promising approach, and a search for Ad viruses which might interact with other proteins known to be at synaptic sites might prove fruitful.
Gene_expression (expression) of CAR in CAR
17) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.51 Pain Relevance 0.17
Generation of constitutive and inducible heart-specific CAR KO mice.
Gene_expression (Generation) of CAR in CAR associated with targeted disruption
18) Confidence 0.50 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.91 Pain Relevance 0
We found that in these animals there was abundant expression of hCAR throughout the brain, with high abundance in both striatum and vMB (Figure 5A, B), and that the presence of this transgenic protein did not appreciably alter the expression of the endogenous mCAR.
Gene_expression (expression) of mCAR in striatum associated with targeted disruption
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.56 Pain Relevance 0.15
Although mCAR and hCAR were readily detectable via western blot in the transgenic hCAR animals, histological imaging of endogenous mCAR proved problematic with the CAR antibodies and amplification techniques available.
Gene_expression (detectable) of mCAR in CAR associated with targeted disruption and imagery
20) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.42 Pain Relevance 0.16

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