INT83953

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 140
Total Number 143
Disease Relevance 113.07
Pain Relevance 43.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
macrophage 21
neutrophil 14
lung 9
plasma 5
liver 4
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3806 100.00 Very High Very High Very High
cytokine 2870 100.00 Very High Very High Very High
chemokine 1139 100.00 Very High Very High Very High
ischemia 396 100.00 Very High Very High Very High
Inflammatory mediators 109 100.00 Very High Very High Very High
Dextromethorphan 14 99.38 Very High Very High Very High
agonist 292 99.22 Very High Very High Very High
Inflammatory response 898 98.88 Very High Very High Very High
fibrosis 817 98.80 Very High Very High Very High
aspirin 52 98.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4541 100.00 Very High Very High Very High
Necrosis 331 100.00 Very High Very High Very High
Cancer 307 100.00 Very High Very High Very High
Adhesions 234 100.00 Very High Very High Very High
Bacterial Infection 73 100.00 Very High Very High Very High
Cv General 4 Under Development 12 100.00 Very High Very High Very High
Keratitis 1704 99.92 Very High Very High Very High
Infection 1636 99.88 Very High Very High Very High
Disease 646 99.76 Very High Very High Very High
Pressure And Volume Under Development 182 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.
Gene_expression (production) of MIP-2 in macrophage associated with chemokine, inflammation and disease
1) Confidence 0.75 Published 2001 Journal Mediators Inflamm Section Abstract Doc Link PMC1781695 Disease Relevance 0.91 Pain Relevance 0.46
Some of the main pathways include the ingestion of apoptotic cells by macrophages which lead to the production of MIP-2 which is a potent chemoattractants for neutrophils.
Gene_expression (production) of MIP-2 in neutrophils associated with apoptosis
2) Confidence 0.74 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.53 Pain Relevance 0.27
The peak expression levels of MIP-2, KC, and IL-1?
Gene_expression (expression) of MIP-2
3) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.90 Pain Relevance 0.36
Evidently, appropriate expression of the major inflammatory cytokines, specifically MIP-2 and IL-1?
Gene_expression (expression) of MIP-2 associated with inflammation and cytokine
4) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.58 Pain Relevance 0.27
At the early stage of the disease (one to three days), the inflammatory responses induced by fungal pathogens is sufficient to resist and kill pathogens and to control the development of disease as long as expression of MIP-2, KC, and IL-1?
Gene_expression (expression) of MIP-2 associated with inflammatory response and disease
5) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.66 Pain Relevance 0.29
Activated PMNs produce MIP-2 (mouse) or IL-8 (human), which produces an auto-amplification loop of PMN recruitment and activation at the inflamed sites, and this positive feedback is considered to be one of the potential mechanisms by which MIP-2 could amplify the local inflammatory response of the PMNs [23,24].
Gene_expression (produce) of MIP-2 associated with inflammatory response
6) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.91 Pain Relevance 0.30
Persistent, high-level expression of MIP-2 and IL-1?
Gene_expression (expression) of MIP-2
7) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.22 Pain Relevance 0.39
polyclonal antibody, the protein expression of MIP-2 and KC significantly decreased in the IL-1?
Gene_expression (expression) of MIP-2
8) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.00 Pain Relevance 0.23
The mRNA data were confirmed by ELISA analysis (Figure 5A), which also showed that the protein levels of MIP-2, KC, IL-1?
Gene_expression (levels) of MIP-2
9) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.65 Pain Relevance 0.35
played a role in regulating the expression of MIP-2 and KC.
Gene_expression (expression) of MIP-2
10) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.08 Pain Relevance 0.23
polyclonal antibody, the severity of corneal disease was significantly reduced, and this was accompanied by a reduction in corneal PMN cells, bacterial load, and MIP-2 mRNA and protein expression.
Gene_expression (expression) of MIP-2 associated with corneal disease
11) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.33 Pain Relevance 0.23
The expression levels of KC and MIP-2 proteins before and after the antibody intervention experiment were analyzed using paired-sample t-test.
Spec (analyzed) Gene_expression (expression) of MIP-2
12) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.34 Pain Relevance 0.20
It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2 (MIP-2), which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.
Gene_expression (production) of inflammatory protein-2 in macrophage associated with chemokine, inflammation and disease
13) Confidence 0.66 Published 2001 Journal Mediators Inflamm Section Abstract Doc Link PMC1781695 Disease Relevance 0.90 Pain Relevance 0.46
In our model there was a successive elevation of all MIP-2 levels up to 24 hours after which the irradiated groups generally maintained their levels whilst the sham levels dropped at 48 hours. 19 Gy irradiation being significantly raised compared to sham treatment at this time point.
Gene_expression (levels) of MIP-2
14) Confidence 0.64 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.55 Pain Relevance 0.24
MIP-2 (human homolog IL-8) is an important chemokine in response to bacterial infection, and maintenance of high MIP-2 expression levels is directly related to an increase in corneal PMNs and severity of corneal inflammation.
Gene_expression (expression) of MIP-2 associated with chemokine, inflammation and bacterial infection
15) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.18 Pain Relevance 0.27
and KC were higher than those of IL-6 and MIP-2.
Gene_expression (higher) of MIP-2
16) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.91 Pain Relevance 0.34
Despite high expression of KC at the mRNA level, KC is expressed far less than MIP-2 at the protein level.
Gene_expression (expressed) of MIP-2
17) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.79 Pain Relevance 0.23
l) of MIP-2 polyclonal antibody (MIP-2 treated group), IL-1?
Gene_expression (antibody) of MIP-2
18) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.27 Pain Relevance 0.11
MIP-2 (human homolog IL-8) is an important chemokine in response to bacterial infection, and maintenance of high MIP-2 expression levels is directly related to an increase in corneal PMNs and severity of corneal inflammation.
Gene_expression (expression) of MIP-2 associated with chemokine, inflammation and bacterial infection
19) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.29 Pain Relevance 0.28
l) of MIP-2 polyclonal antibody (MIP-2 treated group), IL-1?
Gene_expression (group) of MIP-2
20) Confidence 0.64 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.27 Pain Relevance 0.10

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