INT83954

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 17.27
Pain Relevance 7.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcr2) plasma membrane (Cxcr2) intracellular (Cxcr2)
signal transducer activity (Cxcr2)
Anatomy Link Frequency
neutrophil 5
liver 2
lung 2
macrophages 1
granulocytes 1
Cxcr2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 457 100.00 Very High Very High Very High
antagonist 67 99.78 Very High Very High Very High
Inflammation 730 99.38 Very High Very High Very High
Paracetamol 12 98.48 Very High Very High Very High
Opioid 5 98.46 Very High Very High Very High
agonist 19 96.44 Very High Very High Very High
rheumatoid arthritis 232 96.40 Very High Very High Very High
substance P 1 94.60 High High
Analgesic 1 92.48 High High
Osteoarthritis 50 92.40 High High
Disease Link Frequency Relevance Heat
Adhesions 76 99.60 Very High Very High Very High
Disease 135 99.56 Very High Very High Very High
Injury 278 99.48 Very High Very High Very High
INFLAMMATION 767 99.38 Very High Very High Very High
Immunization 7 99.04 Very High Very High Very High
Infection 63 99.02 Very High Very High Very High
Hepatotoxicity 3 98.94 Very High Very High Very High
Lung Injury 280 98.32 Very High Very High Very High
Toxicity 3 97.60 Very High Very High Very High
Pneumonia 88 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligation of the neutrophil CXC-Receptor-2 (CXCR2) by these agents is essential for activation of the ?
CXCR2 Binding (Ligation) of in neutrophil
1) Confidence 0.37 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.68 Pain Relevance 0.26
Ligation of the neutrophil CXC-Receptor-2 (CXCR2) by these agents is essential for activation of the ?
neutrophil CXC-Receptor-2 Binding (Ligation) of in neutrophil
2) Confidence 0.37 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.68 Pain Relevance 0.26
We observe the dimer binds CXCR2 receptor with lower affinity and is less active for functions such as endocytosis and as active as the monomer for functions such as receptor phosphorylation and internalization.
CXCR2 Binding (binds) of
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909905 Disease Relevance 0 Pain Relevance 0.06
This study seeks to further investigate the mechanisms involved in acetaminophen-induced hepatotoxicity and the role of chemokine (C-X-C motif) receptor 2 (CXCR2) receptor/ligand interactions in the liver's response to and recovery from acetaminophen toxicity.
CXCR2 Binding (interactions) of in liver associated with chemokine, toxicity, paracetamol and hepatotoxicity
4) Confidence 0.36 Published 2010 Journal Hepatology Section Abstract Doc Link 20683965 Disease Relevance 0.91 Pain Relevance 0.67
This suggests that if other leukocytes are recruited there are redundant pathways involved in their recruitment that are CXCR2-independent.
CXCR2 Binding (recruitment) of in leukocytes
5) Confidence 0.34 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.01 Pain Relevance 0.14
Collectively, these studies demonstrate that augmented levels of CXCR2 ligands are important in the recruitment of neutrophils during the pathogenesis of inflammatory diseases and suggest that the interaction between CXCR2 ligands and CXCR2 may be pivotal in the recruitment of neutrophils to the lung during dsRNA-induced lung injury.
CXCR2 Binding (interaction) of in neutrophils associated with lung injury, inflammation and disease
6) Confidence 0.34 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.23 Pain Relevance 0.19
CXCR2 is the shared cellular receptor for the murine CXC chemokine ligands KC/CXCL1 and MIP-2/CXCL2/3 [18-20].
CXCR2 Binding (ligands) of associated with chemokine
7) Confidence 0.34 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.26 Pain Relevance 0.16
The goat was immunized with CXCR2 in multiple intradermal sites with complete Freund's adjuvant (CFA) followed by at least 3 boosts of CXCR2 in incomplete Freund's adjuvant (IFA) as previously described. [24-31].
CXCR2 Binding (immunized) of
8) Confidence 0.34 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.34 Pain Relevance 0.09
In this study, we hypothesized that the interaction between CXCR2 and ELR-positive CXC chemokines expressed during dsRNA-induced lung inflammation is critical in mediating neutrophil recruitment, a pivotal process required for dsRNA induced lung injury in viral infections.
CXCR2 Binding (interaction) of in lung associated with lung injury, chemokine, inflammation, viral infection and pneumonia
9) Confidence 0.34 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.65 Pain Relevance 0.42
Based on these findings, we performed proof of principle studies in vivo using an antibody-mediated neutralization strategy to evaluate the direct role for CXCL1 and CXCL2/3 ligands and their interaction with CXCR2 during the pathogenesis of dsRNA-induced lung injury.
CXCR2 Binding (interaction) of in lung associated with lung injury
10) Confidence 0.33 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 1.07 Pain Relevance 0.14
Here, we show that in the presence of an antibody that blocks chemokine interactions with CXCR2, neutrophils roll on the endothelial cell surface indefinitely (Figure 2), demonstrating that a chemokine signal is essential for neutrophil activation on TNF-stimulated endothelial cells.
CXCR2 Binding (interactions) of in endothelial cell associated with chemokine
11) Confidence 0.29 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2718617 Disease Relevance 0.59 Pain Relevance 0.26
Polyclonal goat anti-murine CXCR2 was produced by the immunization of a goat with a peptide containing the ligand-binding sequence Met-Gly-Glu-Phe-Lys-Val-Asp-Lys-Phe-Asn-Ile-Glu-Asp-Phe-Phe-Ser-Gly of CXCR2 [24-31].
CXCR2 Binding (binding) of associated with immunization
12) Confidence 0.29 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1156932 Disease Relevance 0.41 Pain Relevance 0.12
and CXCR2 (IL-8 receptor ?)
CXCR2 Binding (receptor) of
13) Confidence 0.29 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.32 Pain Relevance 0.65
However, AdMIP-2 infection in mice lacking the CXC chemokine receptor that binds MIP-2, CXCR2, did not attenuate any of the markers of liver injury after adenovirus and acetaminophen challenge.
CXCR2 Binding (binds) of in liver associated with chemokine, paracetamol, injury and infection
14) Confidence 0.27 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10476217 Disease Relevance 0.97 Pain Relevance 0.70
On the basis of our data, we propose that dynamic equilibrium between CXCL8 monomers and dimers and their differential binding to CXCR2 and GAGs mediates and regulates in vivo neutrophil recruitment.
CXCR2 Binding (binding) of in neutrophil
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2909905 Disease Relevance 0.16 Pain Relevance 0.05
(CXCL1), bind to the receptor CXCR2 to promote neutrophil chemotaxis and can also affect angiogenesis.
CXCR2 Binding (bind) of in neutrophil
16) Confidence 0.23 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.08 Pain Relevance 0.40
CXCL1 binds to the chemokine receptors CXCR1 and CXCR2.
CXCR2 Binding (binds) of associated with chemokine
17) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.03 Pain Relevance 0.19
Opioid peptide release from granulocytes can be stimulated by chemokines, such as, CXCR2 ligands.
CXCR2 Binding (ligands) of in granulocytes associated with chemokine and opioid
18) Confidence 0.18 Published 2008 Journal Br J Anaesth Section Abstract Doc Link 18397920 Disease Relevance 0.34 Pain Relevance 1.13
Both bind to their receptor CXCR2 whereas CXCL8 binds also to CXCR1.
CXCR2 Binding (bind) of
19) Confidence 0.17 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.65 Pain Relevance 0.18
These data point to the potential need for development of novel antagonists of CXCR1, CXCR2 or their ligands CXCL1 and CXCL8.
CXCR2 Binding (ligands) of associated with antagonist
20) Confidence 0.17 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.52 Pain Relevance 0.33

General Comments

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