INT83955

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 9.77
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
leukocytes 1
knee joint 1
lung 1
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 246 100.00 Very High Very High Very High
chemokine 148 100.00 Very High Very High Very High
Paracetamol 7 100.00 Very High Very High Very High
Inflammation 313 99.80 Very High Very High Very High
Arthritis 7 98.96 Very High Very High Very High
Morphine 9 96.86 Very High Very High Very High
fibrosis 66 92.96 High High
Inflammatory stimuli 3 85.36 High High
Inflammatory response 79 83.96 Quite High
antagonist 7 83.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 381 99.80 Very High Very High Very High
Pseudomonas Infection 20 99.56 Very High Very High Very High
Infection 118 99.04 Very High Very High Very High
Arthritis 6 98.96 Very High Very High Very High
Keratitis 140 98.26 Very High Very High Very High
Necrosis 19 97.08 Very High Very High Very High
Fibrosis 47 96.60 Very High Very High Very High
Disease 64 96.00 Very High Very High Very High
Cancer 14 95.24 Very High Very High Very High
Injury 136 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent reports indicate that MIP-2 is also regulated by oxygen radicals [21].
Regulation (regulated) of MIP-2
1) Confidence 0.58 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.56 Pain Relevance 0.25
is the major cytokine responsible for regulation of MIP-2 and KC.
Regulation (regulation) of MIP-2 associated with cytokine
2) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.23 Pain Relevance 0.38
Evidently, appropriate expression of the major inflammatory cytokines, specifically MIP-2 and IL-1?
Regulation (specifically) of MIP-2 associated with inflammation and cytokine
3) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.50 Pain Relevance 0.25
The reader needs to be reminded that the data presented is preliminary and that further investigation is necessary in order to better elucidate the differential regulation of IL-6, MIP-2, and KC, as a result of gender dimorphism during hepatic I/R.
Regulation (regulation) of MIP-2
4) Confidence 0.40 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.22 Pain Relevance 0.20
Further, the study suggested differential regulation of the two chemokines, i.e., KC, and MIP-2, in hepatic IR response.
Regulation (regulation) of MIP-2 associated with chemokine
5) Confidence 0.40 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.30 Pain Relevance 0.27
Specifically, the high up-regulation of several chemokines (CXCL2, CCL5, CXCL5, CXCL9, CXCL1 CXCL10) which control the recruitment of leukocytes to the vaccination site is important for the early phases of the immune response [45].
Regulation (regulation) of CXCL2 in leukocytes associated with chemokine
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748717 Disease Relevance 0.25 Pain Relevance 0.18
In an experimental Pseudomonas aeruginosa keratitis study, the susceptibility to infection by Pseudomonas aeruginosa was shown to involve dysregulation of the local host response including persistence of PMNs and increased levels of IL-1 and MIP-2.
Regulation (dysregulation) of MIP-2 associated with pseudomonas infection, keratitis and infection
7) Confidence 0.26 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 2.20 Pain Relevance 0.46
The combination of Ad70-3 infection and an intraperitoneal challenge with 400 mg/kg of acetaminophen was fatal in 50% of the mice, but only 10% of the AdMIP-2 group receiving acetaminophen were similarly affected.
Regulation (affected) of AdMIP-2 associated with paracetamol and infection
8) Confidence 0.24 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10476217 Disease Relevance 1.02 Pain Relevance 0.66
However, in this study CO inhalation had no impact on lavage fluid IL-6, IL-10, or the CXC chemokines MIP-2 and KC.
Neg (no) Regulation (impact) of MIP-2 associated with chemokine
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903490 Disease Relevance 0.34 Pain Relevance 0.22
Taken together, these results suggest that chronic morphine treatment in an S. pneumoniae infection model suppresses NF-kappaB gene transcription in lung resident cells, which, in turn, modulates the transcriptional regulation of MIP-2 and inflammatory cytokines.
Regulation (regulation) of MIP-2 in lung associated with inflammation, infection, cytokine and morphine
10) Confidence 0.13 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.59 Pain Relevance 0.87
There were a few unexpected findings in this study, namely the prolonged upregulation of proinflammatory cytokines, including neutrophilic chemokines, KC and MIP-2, and subsequent neutrophilic inflammation following bleomycin administration in acatalasemic mice.
Regulation (upregulation) of MIP-2 associated with chemokine, inflammation and cytokine
11) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.69 Pain Relevance 0.38
The concentrations of MIP-2 and TNF-?
Regulation (concentrations) of MIP-2
12) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2212713 Disease Relevance 0.19 Pain Relevance 0.09
In this model, rapid up-regulation of KC and MIP-2 precedes the recruitment of neutrophils into the knee joint.
Regulation (regulation) of MIP-2 in knee joint
13) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.46 Pain Relevance 0.15
Following administration of DNA nanoparticles to murine airways, there were no systemic alterations in serum chemistry, hematologic parameters, serum complement levels, IL-6 levels, MIP-2 levels, or in the activity, growth, and grooming of the mice [18].
Neg (no) Regulation (alterations) of MIP-2
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756629 Disease Relevance 0.22 Pain Relevance 0.08

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