INT83958

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Context Info
Confidence 0.37
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
nerves 2
gut 2
Npy (Mus musculus)
Pain Link Frequency Relevance Heat
guanethidine 1 99.98 Very High Very High Very High
tetrodotoxin 3 99.64 Very High Very High Very High
Action potential 4 93.44 High High
Neuropeptide 5 85.64 High High
substance P 1 84.40 Quite High
Calcitonin gene-related peptide 1 83.36 Quite High
Enkephalin 3 80.72 Quite High
antagonist 25 42.56 Quite Low
agonist 15 39.12 Quite Low
Central nervous system 15 36.72 Quite Low
Disease Link Frequency Relevance Heat
Anorexia 14 81.40 Quite High
Obesity 58 65.24 Quite High
Adhesions 1 62.96 Quite High
Sprains And Strains 5 44.40 Quite Low
Hyperinsulinism 1 29.28 Quite Low
Appetite Loss 10 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Weight Gain 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with prazosin or haloperidol affected neither the release of NPY nor the morphologic changes; pretreatment with tetrodotoxin and guanethidine abolished NPY release and prevented the PTX-B-induced morphologic changes.
Negative_regulation (abolished) of Localization (release) of NPY associated with tetrodotoxin and guanethidine
1) Confidence 0.37 Published 1999 Journal Peptides Section Abstract Doc Link 10477080 Disease Relevance 0 Pain Relevance 0.39
After a meal, the gut releases PYY3–36 into the circulation, which crosses the BBB and reduces food intake by suppressing NPY release and increasing POMC release in the arcuate nucleus [77-80].
Negative_regulation (suppressing) of Localization (release) of NPY in gut
2) Confidence 0.37 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.28 Pain Relevance 0.08
NPY released from other non-adrenergic, non-cholinergic secretomotor nerves could auto-inhibit NPY release by Y2 receptor activation and local NPY, NPY(3–36), PYY, or PYY(3–36) could act on these neuronal Y2 receptors to modulate ongoing mucosal electrolyte secretion.
Negative_regulation (inhibit) of Localization (release) of NPY in nerves
3) Confidence 0.21 Published 2008 Journal Nutrition Section Body Doc Link PMC2572019 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

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