INT83991

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 9.89
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
endothelial cells 2
CPA 2
spinal cord 1
eosinophil 1
5A1 1
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 7 100.00 Very High Very High Very High
tolerance 218 99.86 Very High Very High Very High
Tetrahydrobiopterin 4 99.56 Very High Very High Very High
medulla 57 99.34 Very High Very High Very High
Bioavailability 19 98.72 Very High Very High Very High
neuralgia 3 98.44 Very High Very High Very High
opiate 2 97.54 Very High Very High Very High
ischemia 147 97.04 Very High Very High Very High
Spinal cord 36 91.60 High High
Dorsal horn 32 90.64 High High
Disease Link Frequency Relevance Heat
Injury 90 99.48 Very High Very High Very High
Diabetes Mellitus 430 99.22 Very High Very High Very High
Aseptic Necrosis Of Bone 3 99.20 Very High Very High Very High
Stress 55 99.18 Very High Very High Very High
Neuralgia 2 98.44 Very High Very High Very High
Hypoxia 18 97.32 Very High Very High Very High
Cv Unclassified Under Development 135 97.04 Very High Very High Very High
Hematological Disease 24 95.24 Very High Very High Very High
Increased Venous Pressure Under Development 83 93.04 High High
Disease 19 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a previous study, these authors demonstrated an enhanced renal expression of iNOS 5 days post diabetes that was sustained for 20 days, while eNOS and nNOS were not altered [37].
Neg (not) Regulation (altered) of eNOS associated with diabetes mellitus
1) Confidence 0.44 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.89 Pain Relevance 0.04
In conclusion, we demonstrated a novel redox mechanism in IP-induced eNOS and GLUT-4 translocation and the role of caveolar paradox in making the heart euglycemic during the process of ischemia, leading to myocardial protection in a clinically relevant rat ischemic model.
Regulation (role) of eNOS in heart associated with ischemia
2) Confidence 0.42 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17277024 Disease Relevance 0.24 Pain Relevance 0.18
Figure 2 also shows that the iNOS and eNOS isoforms could not be detected in dorsal horns from normal control rats.
Neg (not) Regulation (detected) of eNOS in dorsal horns
3) Confidence 0.38 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.18 Pain Relevance 0.31
In addition, diminished levels of the essential eNOS cofactor, tetrahydrobiopterin, results in uncoupling of eNOS and enhanced O2??
Regulation (levels) of eNOS associated with tetrahydrobiopterin
4) Confidence 0.34 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 1.01 Pain Relevance 0.21
The existence of iNOS mRNA and protein has also been reported for rat neutrophil, eosinophil, megakaryocyte, and unstimulated monocyte, and those of eNOS of lymphocyte, megakaryocyte, and platelet and nNOS of neutrophil [16-18].
Regulation (reported) of eNOS in neutrophil
5) Confidence 0.34 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
Contrary to marrow, a gradual increase of neutrophil levels of NOS reaction metabolites are observed resulted from the up-regulation of both iNOS and cNOS that might be involved in the development of granulopenia, and cytopenia in blood 9 and 18 days pt.
Regulation (regulation) of cNOS in blood
6) Confidence 0.34 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.07 Pain Relevance 0
On 9 day after CPA treatment in vivo and in vitro testing suggest a down-regulation of both cNOS and iNOS in marrow indicating that signals in addition to NO appear to be involved in the inhibitory effect of CPA on hematopoiesis.
Regulation (regulation) of cNOS in CPA associated with hematological disease
7) Confidence 0.34 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.39 Pain Relevance 0.04
A significant up-regulation of eNOS and iNOS in thoracic aorta in 14-days and 28-days diabetes groups was obtained as compared to control group (Fig 5A1–A3).
Regulation (regulation) of eNOS in 5A1 associated with diabetes mellitus
8) Confidence 0.32 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.43 Pain Relevance 0.12
NOS inhibitors alone did not affect the level of nitrate/nitrite, p-nNOS, p-eNOS, or p-ERK1/2 in the LC.
Neg (not) Regulation (affect) of p-eNOS
9) Confidence 0.22 Published 2010 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 20028349 Disease Relevance 0 Pain Relevance 0
Dyn A(1-17) 20 nmol also significantly increased the activities of cNOS in the ventral spinal cord but did not affect cNOS activities in the dorsal spinal cord.
Neg (not) Regulation (affect) of cNOS in spinal cord
10) Confidence 0.22 Published 1999 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 11601043 Disease Relevance 0.06 Pain Relevance 0
It is not excluded that CPA-induced elevation of intracellular calcium concentrations trigger an up-regulation of cNOS observed in all leucocyte subpopulations 18 day pt, (the cNOS even dominates in monocyte - its activity is 2.6 times higher than that iNOS).
Regulation (regulation) of cNOS in CPA
11) Confidence 0.20 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.07 Pain Relevance 0
In kidney medulla we did not find any significant change in eNOS and iNOS in 14-days and 28-days diabetes groups as compared to control group (Fig 5C1–C3).


Regulation (change) of eNOS in kidney medulla associated with medulla and diabetes mellitus
12) Confidence 0.19 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.25 Pain Relevance 0.16
However, studies in normal primary human coronary artery endothelial cells in vitro have demonstrated a similar lack of overt exenatide effect on eNOS and AKT2 protein expression on a background of enhanced activation of both proteins [39].
Regulation (effect) of eNOS in endothelial cells
13) Confidence 0.18 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2996354 Disease Relevance 0.24 Pain Relevance 0
Either in human or laboratory animals, the cardiovascular benefits of exercise training have been associated with a variety of cellular and molecular alterations including up-regulation of endothelial NO synthase (eNOS), increase in expression and/or activity of antioxidant enzymes, as well as decrease in prooxidant enzyme systems [34,35].
Regulation (regulation) of eNOS
14) Confidence 0.18 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.23 Pain Relevance 0.06
This agent had no effect upon eNOS, but completely suppressed iNOS mRNA levels.
Neg (no) Regulation (effect) of eNOS
15) Confidence 0.15 Published 2000 Journal Inflamm. Res. Section Body Doc Link 11211925 Disease Relevance 0 Pain Relevance 0
The existence of iNOS mRNA and protein has also been reported for rat neutrophil, eosinophil, megakaryocyte, and unstimulated monocyte, and those of eNOS of lymphocyte, megakaryocyte, and platelet and nNOS of neutrophil [16-18].
Regulation (reported) of eNOS in megakaryocyte
16) Confidence 0.11 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
The existence of iNOS mRNA and protein has also been reported for rat neutrophil, eosinophil, megakaryocyte, and unstimulated monocyte, and those of eNOS of lymphocyte, megakaryocyte, and platelet and nNOS of neutrophil [16-18].
Regulation (reported) of eNOS in eosinophil
17) Confidence 0.11 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0
RT-PCR failed to detect any change in levels of nNOS, eNOS, iNOS, COX-1 or COX-2 mRNAs.
Regulation (change) of eNOS
18) Confidence 0.11 Published 2000 Journal Pain Section Abstract Doc Link 10812261 Disease Relevance 0.87 Pain Relevance 0.56
Albeit the changes in mRNA of eNOS and iNOS were not statistically significant, they tended to be elevated prior to the increase in protein expression of the respective isoenzyme.
Regulation (changes) of eNOS
19) Confidence 0.10 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.58 Pain Relevance 0
Data suggest that generation of NO is crucial for the induction of IT, as a dependence on endothelial NO synthase (eNOS), but not on the neuronal NOS (nNOS) in newborn rats subjected to hypoxic-PC [165].
Neg (not) Regulation (dependence) of eNOS in neuronal associated with addiction, hypoxia and tolerance
20) Confidence 0.10 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.18 Pain Relevance 0.79

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