INT83995

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.09
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
vasculature 4
pancreas 2
heart 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 36 97.48 Very High Very High Very High
abdominal pain 1 88.44 High High
Glutamate receptor 1 86.08 High High
gABA 1 82.44 Quite High
cva 7 76.32 Quite High
chemokine 8 61.44 Quite High
cytokine 31 60.84 Quite High
Inflammation 54 60.44 Quite High
Inflammatory response 14 41.40 Quite Low
antagonist 21 39.52 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 61 99.82 Very High Very High Very High
Hypoxia 23 99.52 Very High Very High Very High
Cardiovascular Disease 52 99.16 Very High Very High Very High
Increased Venous Pressure Under Development 32 97.96 Very High Very High Very High
Pressure And Volume Under Development 30 97.92 Very High Very High Very High
Calcification 1 96.96 Very High Very High Very High
Atherosclerotic Plaque 6 95.72 Very High Very High Very High
Hypertrophy 8 95.28 Very High Very High Very High
Heart Rate Under Development 34 94.72 High High
Hypercalcemia 3 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Positive_regulation (Increased) of Gene_expression (expression) of ACE in vasculature associated with atherosclerotic plaque and pressure and volume under development
1) Confidence 0.68 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.60 Pain Relevance 0.11
Increased expression of tissue ACE has been found in the vasculature of subjects with hypertension and in the microvasculature throughout an atherosclerotic plaque, suggesting that the accumulation of ACE in the plaque contributes to increased local production of Ang II (Gibbons 1995; Diet et al 1996).
Positive_regulation (Increased) of Gene_expression (expression) of ACE in vasculature associated with atherosclerotic plaque and pressure and volume under development
2) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.60 Pain Relevance 0.11
Levels of angiotensin converting enzyme (30.2 IU/l) and 1.25 (OH)2VitD3 (66.4 pg/ml) were elevated.
Positive_regulation (elevated) of Gene_expression (Levels) of angiotensin converting enzyme
3) Confidence 0.44 Published 1999 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 10481465 Disease Relevance 1.34 Pain Relevance 0.09
CONCLUSIONS: Our results showed that serum ACE levels increased in neither benign nor malignant pancreas diseases.
Neg (neither) Positive_regulation (increased) of Gene_expression (levels) of serum ACE in pancreas
4) Confidence 0.44 Published 2008 Journal Hepatogastroenterology Section Body Doc Link 19102399 Disease Relevance 0.06 Pain Relevance 0
The rationale behind this study was based on the findings that angiotensin converting enzyme and angiotensin II are both involved in the pulmonary vascular remodelling associated with hypoxic pulmonary hypertension [13,29] Angiotensin converting enzyme expression is increased in the remodelled arteries of patients with plexogenic pulmonary hypertension [30].
Positive_regulation (increased) of Gene_expression (expression) of Angiotensin converting enzyme associated with pulmonary hypertension and hypoxia
5) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1198258 Disease Relevance 0.99 Pain Relevance 0
In the hypoxic rat model both captopril, an angiotensin converting enzyme inhibitor, and losartan have been shown to prevent the haemodynamic and structural changes of pulmonary hypertension without inhibiting acute hypoxic vasoconstriction [13,31] In addition, right ventricular remodelling in the chronically hypoxic rat is associated with increased angiotensin converting enzyme expression and activity [32].
Positive_regulation (increased) of Gene_expression (expression) of angiotensin converting enzyme associated with pulmonary hypertension, hypoxia and increased venous pressure under development
6) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC1198258 Disease Relevance 1.24 Pain Relevance 0
Since ACE produces angiotensin II in the heart,
Positive_regulation (Since) of Gene_expression (produces) of ACE in heart
7) Confidence 0.14 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.28 Pain Relevance 0.33
Several antihypertensive drugs such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blocker (ARB), and ?
Positive_regulation (Several) of Gene_expression (Several) of angiotensin-converting enzyme
8) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.49 Pain Relevance 0.09
Several antihypertensive drugs such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blocker (ARB), and ?
Positive_regulation (as) of Gene_expression (Several) of angiotensin-converting enzyme
9) Confidence 0.03 Published 2010 Journal PPAR Research Section Body Doc Link PMC2931381 Disease Relevance 1.49 Pain Relevance 0.09

General Comments

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