INT84005

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.55
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
melanocyte 2
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 43 100.00 Very High Very High Very High
Morphine 7 99.82 Very High Very High Very High
intrathecal 3 99.68 Very High Very High Very High
Inflammation 17 99.52 Very High Very High Very High
Neurotransmitter 5 99.52 Very High Very High Very High
Endocannabinoid 117 99.22 Very High Very High Very High
Dorsal horn 1 99.04 Very High Very High Very High
fibrosis 12 98.84 Very High Very High Very High
Neuropeptide 1 98.58 Very High Very High Very High
Spinal cord 1 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 20 99.52 Very High Very High Very High
Stress 40 99.30 Very High Very High Very High
Obesity 189 98.84 Very High Very High Very High
Fibrosis 11 98.84 Very High Very High Very High
Primary Sclerosing Cholangitis 44 98.36 Very High Very High Very High
Depression 12 95.48 Very High Very High Very High
Pancreatitis 32 90.56 High High
Syndrome 1 84.32 Quite High
Insulin Resistance 20 80.80 Quite High
Diabetes Mellitus 73 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, high levels of 2-AG dampen HPA-axis activity whereas a stress associated decline in 2-AG levels reduced activation of CB1-receptors resulting in increased HPA-axis activity [38].
Negative_regulation (reduced) of Positive_regulation (activation) of CB1 associated with stress
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873996 Disease Relevance 0.97 Pain Relevance 0.15
Cannabinoid receptor activation reduces markers of inflammation and fibrosis in PSC
Negative_regulation (reduces) of Positive_regulation (activation) of Cannabinoid receptor associated with fibrosis, inflammation, cannabinoid receptor and primary sclerosing cholangitis
2) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.83 Pain Relevance 0.50
Together, these results strongly support the hypothesis that cannabinoid receptor activation decreases EPSC size by reducing release of neurotransmitter presynaptically while having no effect on postsynaptic sensitivity to glutamate.
Negative_regulation (reducing) of Positive_regulation (activation) of cannabinoid receptor associated with glutamate, neurotransmitter and cannabinoid receptor
3) Confidence 0.27 Published 1999 Journal J. Neurophysiol. Section Abstract Doc Link 10482747 Disease Relevance 0.10 Pain Relevance 0.90
Therefore, the SAT of OBT2D subjects might be characterized by a relatively decreased activity of CB1 receptors, and strongly increased activity of PPAR?
Negative_regulation (decreased) of Positive_regulation (activity) of CB1 associated with obesity
4) Confidence 0.19 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 0.78 Pain Relevance 0.28
This morphine-induced CB-1 and CB-2 upregulation was dose-dependently attenuated by the intrathecal co-administration of morphine with the glucocorticoid receptor (GR) antagonist RU38486 (0.25, 0.5, or 2 microg).
Negative_regulation (attenuated) of Positive_regulation (upregulation) of CB-1 associated with antagonist, intrathecal and morphine
5) Confidence 0.13 Published 2005 Journal Brain Res. Section Abstract Doc Link 16150424 Disease Relevance 0 Pain Relevance 1.32
Under normal conditions, when leptin levels rise, production of central anorexigenic neuropeptides is upregulated, endocannabinoid activity decreases, and the resulting decrease in CB1 receptor activation reduces appetite and food-seeking behavior (Di Marzo et al. 2001).
Negative_regulation (decrease) of Positive_regulation (activation) of CB1 associated with endocannabinoid and neuropeptide
6) Confidence 0.12 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012438 Disease Relevance 0.87 Pain Relevance 0.18
CONCLUSIONS: Relaxation to TRPA1 agonists in human urethral preparations seem to work in cooperation with TRPV1 mediated signals, are negatively coupled via cannabinoid receptor activation and involve cyclooxygenase products.
Negative_regulation (coupled) of Positive_regulation (activation) of cannabinoid receptor
7) Confidence 0.11 Published 2010 Journal J. Urol. Section Body Doc Link 20303522 Disease Relevance 0 Pain Relevance 0
Genes affected similarly by Delta(9)-THC and R(+)-WIN 55,212-2 were considered likely to reflect cannabinoid receptor activation, and expression of the protein products of two such genes not previously implicated in cannabinoid signaling-melanocyte-specific gene-related gene 1 (MRG1) and hexokinase 4 (glucokinase, GK)-was measured by Western blotting and immunohistochemistry.
Spec (likely) Negative_regulation (reflect) of Positive_regulation (activation) of cannabinoid receptor in melanocyte associated with cannabinoid receptor and cannabinoid
8) Confidence 0.01 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12237329 Disease Relevance 0 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox