INT84020

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Context Info
Confidence 0.47
First Reported 1999
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 11.92
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (RNASE3)
Anatomy Link Frequency
eosinophil 5
nasal 3
nasal mucosa 2
tear 1
sputum 1
RNASE3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 362 100.00 Very High Very High Very High
cytokine 127 100.00 Very High Very High Very High
Inflammatory marker 13 86.76 High High
metalloproteinase 3 79.16 Quite High
local anesthetic 4 75.52 Quite High
Multiple sclerosis 32 74.52 Quite High
corticosteroid 18 74.08 Quite High
intrathecal 4 73.84 Quite High
cerebral cortex 2 58.92 Quite High
medulla 6 57.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 370 100.00 Very High Very High Very High
Rhinitis 190 100.00 Very High Very High Very High
Neuromyelitis Optica 430 99.84 Very High Very High Very High
Chronic Sinusitis 47 99.50 Very High Very High Very High
Conjunctiva Disease 37 99.48 Very High Very High Very High
Pulmonary Disease 112 98.76 Very High Very High Very High
Nasal Polyps 57 98.66 Very High Very High Very High
Mucositis 28 98.64 Very High Very High Very High
Hypersensitivity 145 94.32 High High
Pneumonia 2 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucosal inflammation symptoms correlated with increased levels of albumin, but not with increased levels of ECP, secreted proinflammatory cytokines or cytokine gene mRNA expression.
Neg (not) Positive_regulation (increased) of ECP associated with mucositis, inflammation and cytokine
1) Confidence 0.47 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.55 Pain Relevance 0.46
Mucosal inflammation symptoms correlated with increased levels of albumin, but not with increased levels of ECP, secreted proinflammatory cytokines or cytokine gene mRNA expression.
Neg (not) Positive_regulation (increased) of ECP associated with mucositis, inflammation and cytokine
2) Confidence 0.34 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.55 Pain Relevance 0.46
Also, major basic protein, nitric oxide, and eotaxin were found in the tissue, and eosinophil cationic protein and eosinophil protein X levels were elevated in sera.
Positive_regulation (elevated) of eosinophil cationic protein in eosinophil
3) Confidence 0.29 Published 1999 Journal J. Allergy Clin. Immunol. Section Body Doc Link 10482840 Disease Relevance 0.17 Pain Relevance 0
Furthermore, increased levels of eosinophil cationic protein (ECP) and albumin, but not tryptase, in nasal lavage from workers exposed to UV coatings have been observed.
Positive_regulation (increased) of ECP in nasal
4) Confidence 0.27 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.21 Pain Relevance 0.13
Furthermore, increased levels of eosinophil cationic protein (ECP) and albumin, but not tryptase, in nasal lavage from workers exposed to UV coatings have been observed.
Positive_regulation (increased) of eosinophil cationic protein in nasal
5) Confidence 0.27 Published 2001 Journal Acta Otolaryngol. Section Abstract Doc Link 11678174 Disease Relevance 0.20 Pain Relevance 0.13
We found increases in ECP, G-CSF, IL-5, and/or IL-6 after exposure to DEHPlow house dust.
Positive_regulation (increases) of ECP
6) Confidence 0.12 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592268 Disease Relevance 0.34 Pain Relevance 0.13
Not only the eosinophils themselves, but also their products such as eosinophil cationic protein are increased in sputum and in serum during COPD exacerbations (Fiorini et al 2000; Fujimoto et al 2005).
Positive_regulation (increased) of eosinophil cationic protein in eosinophil associated with pulmonary disease
7) Confidence 0.10 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 0.52 Pain Relevance 0.07
In our previous study, involving patients with allergic rhinitis examined out of season, we observed moderately increased lavage fluid levels of ECP 24 hours after nasal TNF?
Positive_regulation (increased) of ECP in nasal associated with rhinitis
8) Confidence 0.07 Published 2008 Journal Respir Res Section Body Doc Link PMC2253533 Disease Relevance 0.54 Pain Relevance 0.03
After exposure to DEHPhigh house dust ECP, G-CSF, IL-5, and/or IL-6 were not increased.
Neg (not) Positive_regulation (increased) of ECP
9) Confidence 0.05 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592268 Disease Relevance 0.32 Pain Relevance 0.12
Eosinophils, ECP, and MCP-1 increased significantly in induced sputum 8 hr after the allergen challenge compared with levels measured at baseline.
Positive_regulation (increased) of ECP in sputum
10) Confidence 0.05 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1817692 Disease Relevance 0 Pain Relevance 0
ECP was significantly increased in CRS compared to the control group (p < 0.05) and even more in CRS-NP (p < 0.02).
Positive_regulation (increased) of ECP
11) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.49 Pain Relevance 0.12
Previous studies have shown that some specific tear proteins, such as IgE, eosinophil major basic protein, and eosinophil cationic protein, are increased in tears of AC patients [13-15,30,31].
Positive_regulation (increased) of eosinophil cationic protein in tear associated with conjunctiva disease
12) Confidence 0.03 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965574 Disease Relevance 1.19 Pain Relevance 0
Eotaxin-2 and Eotaxin-3, which are selective chemotactic factors for eosinophils, and eosinophil cationic protein were higher in NMO patient CSF than in normal CSF.
Positive_regulation (higher) of eosinophil cationic protein in eosinophil associated with neuromyelitis optica
13) Confidence 0.02 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.28 Pain Relevance 0.25
A Th2 pattern predominates in nasal polyposis, characterized by IgE production, infiltration of eosinophils and upregulation of cytokines and mediators, including IL-5, ECP and eotaxin, that drive eosinophil response.59 Staphylococcus aureus enterotoxins may play a role in the pathophysiology of NP.
Positive_regulation (upregulation) of ECP in eosinophils associated with nasal polyps and cytokine
14) Confidence 0.01 Published 2010 Journal International Journal of General Medicine Section Body Doc Link PMC2866558 Disease Relevance 1.30 Pain Relevance 0.27
The pathophysiology of chronic rhinosinusitis is not fully understood; however, the cytokine and mediator profile in this condition closely resembles the profile found in acute rhinosinusitis, with the exception of a small but significant increase in ECP.38 Nasal tissue samples taken from patients with chronic rhinosinusitis have been shown to have increased levels of leukotrienes C4, D4, and E4 and higher levels of markers of eosinophilic inflammation, such as ECP (Figure 3).46 In addition, a number of studies have reported that markers of atopy are more prevalent in populations with chronic rhinosinusitis.47–49 Although the role of allergy in chronic rhinosinusitis remains controversial, it has been postulated that swelling of the nasal mucosa in allergic rhinitis may restrict ventilation and obstruct sinus ostia, leading to mucus retention and infection.47

Nasal polyposis

Positive_regulation (increase) of ECP in nasal mucosa associated with pressure and volume under development, rhinitis, inflammation, chronic sinusitis, hypersensitivity, nasal polyps, infection and cytokine
15) Confidence 0.01 Published 2010 Journal International Journal of General Medicine Section Body Doc Link PMC2866558 Disease Relevance 1.34 Pain Relevance 0.26
The pathophysiology of chronic rhinosinusitis is not fully understood; however, the cytokine and mediator profile in this condition closely resembles the profile found in acute rhinosinusitis, with the exception of a small but significant increase in ECP.38 Nasal tissue samples taken from patients with chronic rhinosinusitis have been shown to have increased levels of leukotrienes C4, D4, and E4 and higher levels of markers of eosinophilic inflammation, such as ECP (Figure 3).46 In addition, a number of studies have reported that markers of atopy are more prevalent in populations with chronic rhinosinusitis.47–49 Although the role of allergy in chronic rhinosinusitis remains controversial, it has been postulated that swelling of the nasal mucosa in allergic rhinitis may restrict ventilation and obstruct sinus ostia, leading to mucus retention and infection.47

Nasal polyposis

Positive_regulation (increased) of ECP in nasal mucosa associated with pressure and volume under development, rhinitis, inflammation, chronic sinusitis, hypersensitivity, nasal polyps, infection and cytokine
16) Confidence 0.01 Published 2010 Journal International Journal of General Medicine Section Body Doc Link PMC2866558 Disease Relevance 1.66 Pain Relevance 0.24
Eotaxin-2 and Eotaxin-3, which are selective chemotactic factors for eosinophils, and eosinophil cationic protein were higher in NMO patient CSF than in normal CSF.
Positive_regulation (higher) of eosinophil cationic protein in eosinophils associated with neuromyelitis optica
17) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.28 Pain Relevance 0.25

General Comments

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