INT84021

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 6.79
Pain Relevance 3.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
corpus callosum 3
blood 2
Leukocytes 1
nucleus 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 8 99.76 Very High Very High Very High
anesthesia 20 99.66 Very High Very High Very High
Central nervous system 51 98.82 Very High Very High Very High
isoflurane 20 98.50 Very High Very High Very High
Spinal cord 119 91.12 High High
Angina 1 90.60 High High
metalloproteinase 65 86.48 High High
Demyelination 124 83.92 Quite High
Multiple sclerosis 153 77.60 Quite High
Inflammatory demyelinating syndrome 2 72.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 37 99.10 Very High Very High Very High
Multiple Sclerosis 1117 98.52 Very High Very High Very High
Hypercapnia 1 94.48 High High
Disease 136 94.20 High High
Hypoxia 1 93.84 High High
Cv General 3 Under Development 1 90.60 High High
Central Nervous System Disease 16 90.00 High High
Myocardial Infarction 1 89.16 High High
Demyelinating Disease 264 83.92 Quite High
Neuromyelitis Optica 8 78.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, isoflurane anesthesia using KNI-472, unlike pentobarbital anesthesia, did not induce changes in MBP, SBF, or blood gases.
Neg (not) Regulation (changes) of MBP in blood associated with anesthesia and isoflurane
1) Confidence 0.57 Published 2007 Journal Biol. Pharm. Bull. Section Abstract Doc Link 17827727 Disease Relevance 0.25 Pain Relevance 1.70
Leukocytes spontaneously accumulate in the perivascular space in the CNS of transgenic mice which express the chemokine CCL2 under control of a truncated MBP promoter [19].
Regulation (control) of MBP in Leukocytes associated with targeted disruption, chemokine and central nervous system
2) Confidence 0.39 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.75 Pain Relevance 0.48
Vehicle-treated mice had reduced myelin basic protein immunoreactivity as compared to normal controls, while oestrogen receptor ?
Regulation (immunoreactivity) of myelin basic protein
3) Confidence 0.37 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.94 Pain Relevance 0
Therefore, PACAP should be applied at low doses which do not influence the MBP and cerebral circulation to determine the therapeutically useful doses of PACAP for neuroprotection.
Neg (not) Regulation (influence) of MBP
4) Confidence 0.26 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 15518894 Disease Relevance 0.30 Pain Relevance 0.15
One explanation for the unaltered myelin formation despite the altered level of MOG, MAG and MBP might be that the extent of reduction, which is subtle compared with the large reductions observed in the mice without the PGKneo cassette [18], was not enough to induce a significant change in the myelin formation during development.
Regulation (altered) of MBP
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.24 Pain Relevance 0.11
Olig1 is localized in the nucleus during the development phase and may function as a transcriptional regulator for myelin-specific gene expression such as myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) [12], [14].
Regulation (regulator) of myelin basic protein in nucleus
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 1.22 Pain Relevance 0.56
ligand preserved myelin basic protein (MBP) immunoreactivity in the corpus callosum of mice with EAE.
Regulation (immunoreactivity) of myelin basic protein in corpus callosum associated with multiple sclerosis
7) Confidence 0.22 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 1.01 Pain Relevance 0
(B) Upon quantification, myelin basic protein immunoreactivity in the corpus callosum was significantly lower in vehicle-treated EAE mice as compared to normal mice, while oestrogen receptor ?
Regulation (immunoreactivity) of myelin basic protein in corpus callosum associated with multiple sclerosis
8) Confidence 0.22 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.90 Pain Relevance 0
ligand preserved myelin basic protein (MBP) immunoreactivity in the corpus callosum of mice with EAE.
Regulation (immunoreactivity) of MBP in corpus callosum associated with multiple sclerosis
9) Confidence 0.22 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 1.00 Pain Relevance 0
We examined the changes in heart rate (HR), mean blood pressure (mBP), the total score of QTc interval on a 12-lead electrocardiogram (sigma QTc), and ST-T segment, before and after drug administration.
Spec (examined) Regulation (changes) of mBP in blood
10) Confidence 0.00 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10483772 Disease Relevance 0.18 Pain Relevance 0.09

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