INT84026

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 3.12
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC7A7) plasma membrane (SLC7A7) protein complex assembly (SLC7A7)
transmembrane transport (SLC7A7) cellular amino acid metabolic process (SLC7A7)
Anatomy Link Frequency
macrophages 3
monocytes 1
endothelial cells 1
SLC7A7 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 1 98.48 Very High Very High Very High
cytokine 18 97.64 Very High Very High Very High
agonist 40 78.36 Quite High
member 8 5 67.88 Quite High
transdermal 3 59.76 Quite High
Cannabinoid receptor 10 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
cva 6 5.00 Very Low Very Low Very Low
withdrawal 5 5.00 Very Low Very Low Very Low
Endocannabinoid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 10 99.84 Very High Very High Very High
Pulmonary Alveolar Proteinosis 259 99.76 Very High Very High Very High
Pressure And Volume Under Development 5 99.24 Very High Very High Very High
Abdominal Pain 1 98.48 Very High Very High Very High
Renal Disease 13 98.44 Very High Very High Very High
Intellectual Impairment 2 96.52 Very High Very High Very High
Coma 1 95.72 Very High Very High Very High
Osteoporosis 8 95.00 High High
Congenital Anomalies 15 94.44 High High
Spontaneous Remission 7 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate also, for the first time, that SLC7A7 is downstream of GM-CSF signalling and is specifically induced during the maturation of monocytes to macrophages, along with other genes encoding for proteins linked to macrophage functions.
Positive_regulation (induced) of SLC7A7 in macrophages
1) Confidence 0.67 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.07 Pain Relevance 0
Nevertheless, the link between GM-CSF, impaired y+LAT1 expression and surfactant accumulation in LPI remains to be elucidated, and our report is not conclusive, taking into consideration the single case and the possibility, although rare, of a spontaneous remission of PAP.
Positive_regulation (accumulation) of LPI associated with pulmonary alveolar proteinosis and spontaneous remission
2) Confidence 0.59 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.58 Pain Relevance 0
Alternatively, GM-CSF-dependent increase of SLC7A7 mRNA may lead to an enhanced synthesis of y+LAT1 protein that ameliorates macrophage function.
Positive_regulation (increase) of SLC7A7 in macrophage
3) Confidence 0.49 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.30 Pain Relevance 0
However, also the monocytes from the LPI subject responded to rGM-CSF with a 2-fold increase in SLC7A7 mRNA level, although system y+L transport activity remained unaffected.
Positive_regulation (increase) of SLC7A7 in monocytes
4) Confidence 0.45 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.05
GM-CSF induces comparable changes in gene expression also in LPI macrophages, where, however, due to the SLC7A7 mutation, no increase in system y+L activity is observed.
Neg (no) Positive_regulation (increase) of SLC7A7 in macrophages
5) Confidence 0.45 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0.09 Pain Relevance 0
In normal cells the stimulation of system y+L activity upon incubation with rGM-CSF was fully attributable to the induction of SLC7A7 gene (Figure 7, Panel B), thus identifying this gene as a cytokine target.
Positive_regulation (induction) of SLC7A7 associated with cytokine
6) Confidence 0.39 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2999609 Disease Relevance 0 Pain Relevance 0.05
A 37-year-old Japanese man who presented with abdominal pain and subnormal fasting levels of serum L-arginine and L-lysine was found to have LPI.
Positive_regulation (have) of LPI associated with abdominal pain
7) Confidence 0.37 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10484053 Disease Relevance 0.49 Pain Relevance 0.13
In view of the reported more than 10-fold elevation of LPI in cancer-derived ascites fluid (Xiao et al., 2001), our data presented here deserve further attention.
Positive_regulation (elevation) of LPI associated with pressure and volume under development and cancer
8) Confidence 0.25 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0.20 Pain Relevance 0.11
In line with these findings, LPI-induced Ni2+/La3+-insensitive depolarization was prevented by ouabain, an inhibitor of the Na/K-ATPase.
Positive_regulation (induced) of LPI
9) Confidence 0.18 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0
The initial cytosolic Ca2+ elevation upon LPI in the presence of extracellular Ca2+ was accompanied by a transient hyperpolarization that reached maximal amplitude of 11.4 ± 1.7 mV (n= 9) within 100 s.
Positive_regulation (elevation) of LPI
10) Confidence 0.18 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0
LPI elicits biphasic Ca2+ elevation, accompanied by diverse changes in membrane potential
Positive_regulation (elevation) of LPI
11) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0
Because in the cell model used, GPR55 was found to be constitutively expressed and to account for a fast, transient Ca2+ elevation upon stimulation with LPI (Waldeck-Weiermair et al., 2008), the contribution of this receptor to LPI-induced Ca2+ signalling and electrical responses in endothelial cells was further explored.
Positive_regulation (elevation) of LPI in endothelial cells
12) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0
LPI is caused by mutations of the solute carrier family 7A member 7 (SLC7A7) gene [7,8].
Positive_regulation (caused) of LPI
13) Confidence 0.07 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1845139 Disease Relevance 1.38 Pain Relevance 0

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