INT84039

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Context Info
Confidence 0.11
First Reported 1999
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.88
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CPOX) small molecule metabolic process (CPOX) cytoplasm (CPOX)
extracellular space (EGF) signal transduction (EGF) extracellular region (EGF)
EGF (Homo sapiens)
CPOX (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 31 98.04 Very High Very High Very High
aspirin 2 83.92 Quite High
antagonist 1 73.60 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Inflammation 2 14.32 Low Low
Immobilon 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 99.38 Very High Very High Very High
INFLAMMATION 6 93.68 High High
Apoptosis 35 88.16 High High
Adenoma 2 85.32 High High
Death 9 82.88 Quite High
Pancreatic Cancer 5 82.88 Quite High
Colon Cancer 25 80.16 Quite High
Carcinoma 1 74.28 Quite High
Familial Adenomatous Polyposis 5 69.04 Quite High
Adenocarcinoma 1 65.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of COX-2 mRNA was positively correlated with the differentiation status of the tumor of origin for each cell line, COX-2 protein expression was up-regulated by epidermal growth factor when the cells were grown in absence of serum.
epidermal growth factor Positive_regulation (up-regulated) of Gene_expression (expression) of COX associated with cancer
1) Confidence 0.11 Published 1999 Journal Cancer Res. Section Abstract Doc Link 10485483 Disease Relevance 0.71 Pain Relevance 0.23
It is well established that COX-2 protein expression is stimulated by EGF and decreased by EGFR inhibitors [9].
EGF Positive_regulation (stimulated) of Gene_expression (expression) of COX
2) Confidence 0.02 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 1.18 Pain Relevance 0.58

General Comments

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