INT84057

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.50
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
neuronal 2
dorsal 2
neurons 2
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 42 100.00 Very High Very High Very High
Morphine 24 99.98 Very High Very High Very High
intrathecal 10 99.98 Very High Very High Very High
allodynia 7 99.52 Very High Very High Very High
drug abuse 6 99.44 Very High Very High Very High
Pain 57 99.12 Very High Very High Very High
cytokine 28 98.24 Very High Very High Very High
chemokine 94 98.20 Very High Very High Very High
antagonist 65 97.76 Very High Very High Very High
nMDA receptor 38 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 591 100.00 Very High Very High Very High
Ganglion Cysts 42 100.00 Very High Very High Very High
Death 76 99.64 Very High Very High Very High
Neuropathic Pain 90 99.52 Very High Very High Very High
Drug Dependence 6 99.44 Very High Very High Very High
Pain 42 99.12 Very High Very High Very High
Apoptosis 81 99.04 Very High Very High Very High
Toxicity 126 98.08 Very High Very High Very High
Nociception 9 97.76 Very High Very High Very High
INFLAMMATION 21 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the hepatocarcinoma HepG2 cell line we have observed up-regulation of ITIH4 mRNA expression upon dose-response treatments with interleukin-6 (IL-6).
Positive_regulation (up-regulation) of Gene_expression (expression) of ITIH4
1) Confidence 0.50 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.18 Pain Relevance 0.13
We have previously shown that, in CHP100 cells, picomolar concentrations of gp120 produce a significant increase in cell death, which seems to proceed through a Ca(2+) - and NMDA receptor-dependent cascade.
Positive_regulation (increase) of Gene_expression (produce) of gp120 associated with nmda receptor and death
2) Confidence 0.48 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 1.34 Pain Relevance 0.32
Intrathecal gp120 produced time-dependent, site-specific increases in TNF and IL-1 protein release into lumbosacral CSF; parallel cytokine increases in lumbar dorsal spinal cord were also observed.
Positive_regulation (increases) of Gene_expression (produced) of gp120 in dorsal associated with spinal cord, cytokine and intrathecal
3) Confidence 0.48 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11306633 Disease Relevance 1.20 Pain Relevance 1.38
Administration of gp120 alone results in significant increases in reactive oxygen species, whereas coadministration with cortisol increases the amount of lipid
Positive_regulation (Administration) of Gene_expression (Administration) of gp120
4) Confidence 0.35 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.17 Pain Relevance 0.03
Analysis of specific protein actions has demonstrated that gp120 works in part through enhancement of COX-2
Positive_regulation (enhancement) of Gene_expression (works) of gp120
5) Confidence 0.35 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.95 Pain Relevance 0.08
Intraventricular administration of gp120 for up to 7 days resulted in an elevation
Positive_regulation (administration) of Gene_expression (administration) of gp120
6) Confidence 0.35 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.78 Pain Relevance 0.07
The phenotypic changes mapped to the envelope glycoproteins, which differed only in 8 amino acids, and specifically to four amino acid changes in the V1/V2 region of gp120, which probably result in a more open or partially-triggered gp120 conformation.
Positive_regulation (triggered) of Gene_expression (conformation) of gp120
7) Confidence 0.30 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.48 Pain Relevance 0.19
We have previously shown that intrathecal injection of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120, induces mechanical allodynia via the release of proinflammatory cytokines.
Positive_regulation (induces) of Gene_expression (injection) of gp120 associated with allodynia, acquired immune deficiency syndrome or hiv infection, cytokine and intrathecal
8) Confidence 0.24 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 1.09 Pain Relevance 1.13
The combination of a T-tropic form of gp120 with hCD4 did not alter the expression or functional signaling of SDF1/CXCR4 in the DRG, however, increased expression of both MCP1 and CCR2 was observed, in addition to increased functional signaling via CCR2.
Positive_regulation (increased) of Gene_expression (expression) of gp120 associated with dorsal root ganglion
9) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.21 Pain Relevance 0.70
Alterations in non-neuronal cells in the DRG following perineural HIV-1 gp120
Positive_regulation (perineural) of Gene_expression (following) of gp120 in neuronal associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.21 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.53 Pain Relevance 0.16
LM and EM analysis reveals that overt axonal damage is not a consequence of perineural HIV-1 gp120 treatment
Neg (not) Positive_regulation (consequence) of Gene_expression (treatment) of gp120 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.21 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.79 Pain Relevance 0.32
However, the five patients with a history of drug abuse or medical use of morphine had expression of gp120 (brown) in neurons, as shown by double staining with MAP-2 antibody (red) (Fig. 6a), but not in astrocytes (Fig. 6b).
Positive_regulation (had) of Gene_expression (expression) of gp120 in neurons associated with drug abuse and morphine
12) Confidence 0.14 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0.76 Pain Relevance 0.40

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