INT84060

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.33
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Apoe) transport (Apoe) extracellular space (Apoe)
aging (Apoe) extracellular region (Apoe) Golgi apparatus (Apoe)
Anatomy Link Frequency
nerve 1
Apoe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 99.60 Very High Very High Very High
aspirin 8 99.12 Very High Very High Very High
cINOD 15 97.68 Very High Very High Very High
Angina 2 97.52 Very High Very High Very High
Pyramidal cell 24 93.80 High High
antagonist 2 85.96 High High
excitatory amino acid 1 84.00 Quite High
Neuropeptide 1 82.28 Quite High
Neurotransmitter 1 78.64 Quite High
agonist 1 74.76 Quite High
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 3 98.92 Very High Very High Very High
Alzheimer's Dementia 2 98.14 Very High Very High Very High
Atherosclerotic Plaque 1 97.96 Very High Very High Very High
Cv General 3 Under Development 2 97.52 Very High Very High Very High
Myocardial Infarction 1 96.72 Very High Very High Very High
Diabetes Mellitus 2 95.28 Very High Very High Very High
Coronary Artery Disease 5 94.60 High High
Status Epilepticus 57 90.48 High High
Disease 16 86.00 High High
Cardiovascular Disease 1 80.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoE protein modulation was observed at physiological and subphysiological concentrations well below the COX inhibition IC50 values of the NSAIDs used, suggestive of a COX-independent mechanism.
Regulation (modulation) of ApoE associated with cinod
1) Confidence 0.62 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.58 Pain Relevance 0.69
We, therefore, investigated the effects of apoE genotype on patients with acute coronary syndrome, including unstable angina and acute myocardial infarction, in non-diabetic patients.
Spec (investigated) Regulation (effects) of apoE associated with acute coronary syndrome, angina, diabetes mellitus and myocardial infarction
2) Confidence 0.43 Published 1999 Journal Yonsei Med. J. Section Abstract Doc Link 10487142 Disease Relevance 1.42 Pain Relevance 0.16
In contrast to these results, indomethacin and aspirin treatment failed to induce any significant changes in apoE mRNA levels.
Regulation (changes) of apoE associated with aspirin
3) Confidence 0.27 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511323 Disease Relevance 0.51 Pain Relevance 0.69
Furthermore, the enhanced apo E immunoreactivity was also detected in the stratum oriens and radiatum of the CA1 region.
Regulation (immunoreactivity) of apo E
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.15 Pain Relevance 0.15
Efforts to treat the underlying pathology are based on modulation of APP processing in order to decrease the accumulation of beta-amyloid, those to decrease tau hyperphosphorylation, use of nerve growth factors and those based on Apo-E modulation.
Regulation (modulation) of Apo-E in nerve associated with nerve growth factor and alzheimer's dementia
5) Confidence 0.14 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11281812 Disease Relevance 0.68 Pain Relevance 0.35

General Comments

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