INT84068

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Context Info
Confidence 0.42
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.74
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGFBP1) extracellular space (IGFBP1) extracellular region (IGFBP1)
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 14 95.44 Very High Very High Very High
Bioavailability 2 95.44 Very High Very High Very High
Dismenorea 2 87.12 High High
Pain 2 83.32 Quite High
cytokine 4 21.44 Low Low
withdrawal 4 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 23 99.86 Very High Very High Very High
Hyperinsulinism 11 98.86 Very High Very High Very High
Fibromyalgia 13 95.44 Very High Very High Very High
Syndrome 3 91.48 High High
Dysmenorrhea 2 87.12 High High
Hemorrhage 4 86.12 High High
Fatigue 2 83.76 Quite High
Pain 1 83.32 Quite High
Cancer 34 82.44 Quite High
Malignant Neoplastic Disease 2 80.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesize that hyperinsulinaemia which marks the early phase of insulin resistance could decrease IGFBP production.
Negative_regulation (decrease) of Gene_expression (production) of IGFBP associated with hyperinsulinism and insulin resistance
1) Confidence 0.42 Published 2007 Journal BMC Endocr Disord Section Body Doc Link PMC2151943 Disease Relevance 1.37 Pain Relevance 0.05
1 markedly inhibits the expression of PRL, IGFBP-1, and TF mRNAs in DSCs this inhibition was delayed by at least 24 h when compared to the response observed in ESC.
Negative_regulation (inhibits) of Gene_expression (expression) of IGFBP-1
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0.17 Pain Relevance 0.09
In contrast a significant decrease in the amount of IGFBP-1 protein released from the cells was detected after only 2 h incubation with TGF?
Negative_regulation (decrease) of Gene_expression (protein) of IGFBP-1
3) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0
To gain further insight into the mechanisms leading to dysregulation of the GH-IGF-1 axis in these patients, we assessed 24-h spontaneous GH secretion, GH responses to GHRH, and IGF-1 and IGF binding protein (BP)-3 levels before and after 4 days treatment with human (h)GH.
Negative_regulation (assessed) of Gene_expression (levels) of IGF binding protein
4) Confidence 0.18 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10487713 Disease Relevance 1.20 Pain Relevance 0.55

General Comments

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