INT84077

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 6.41
Pain Relevance 10.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
spinal cord 3
central nervous system 2
leukocyte 2
neurons 2
dorsal 1
Hmox2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 75 100.00 Very High Very High Very High
Dorsal horn neuron 17 99.98 Very High Very High Very High
Central nervous system 5 99.68 Very High Very High Very High
Morphine 33 99.64 Very High Very High Very High
allodynia 13 99.62 Very High Very High Very High
adenocard 1 99.48 Very High Very High Very High
Inflammation 45 99.40 Very High Very High Very High
Hyperalgesia 5 99.34 Very High Very High Very High
Dorsal horn 7 99.24 Very High Very High Very High
Pain 36 99.06 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 19 99.62 Very High Very High Very High
INFLAMMATION 49 99.40 Very High Very High Very High
Hyperalgesia 7 99.34 Very High Very High Very High
Pain 21 99.06 Very High Very High Very High
Cancer 4 99.00 Very High Very High Very High
Nociception 40 98.72 Very High Very High Very High
Necrosis 3 98.72 Very High Very High Very High
Disease 88 92.28 High High
Targeted Disruption 3 86.48 High High
Sprains And Strains 4 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these studies, we examined changes in expression of HO-2 which occur in spinal cord tissue of morphine tolerant mice.
Gene_expression (expression) of HO-2 in spinal cord associated with morphine and spinal cord
1) Confidence 0.77 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10686338 Disease Relevance 0.09 Pain Relevance 0.90
Additional experiments revealed a 3.1-fold increase in HO-2 protein which seemed to result from the increased expression of HO-2 in neurons in the dorsal horn region of the spinal cord.
Gene_expression (expression) of HO-2 in neurons associated with dorsal horn and spinal cord
2) Confidence 0.77 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10686338 Disease Relevance 0.07 Pain Relevance 1.31
Chronic morphine exposure and the expression of heme oxygenase type 2.
Gene_expression (expression) of heme oxygenase type 2 associated with morphine
3) Confidence 0.77 Published 2000 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 10686338 Disease Relevance 0.09 Pain Relevance 0.80
In both models of chronic pain it was observed that the extent of hyperalgesia and allodynia was significantly less for the HO-2 null mutants than the wild type mice.
Gene_expression (less) of HO-2 associated with hyperalgesia, allodynia and lasting pain
4) Confidence 0.67 Published 2003 Journal J Pain Section Abstract Doc Link 14622721 Disease Relevance 0.94 Pain Relevance 1.27
In vitro and in vivo pharmacological research has provided some evidence that caffeine can have anti-nociceptive actions through blockade of adenosine receptors, inhibition of cyclo-oxygenase-2 enzyme synthesis, or by changes in emotion state.
Gene_expression (synthesis) of cyclo-oxygenase-2 enzyme associated with nociception and adenocard
5) Confidence 0.65 Published 2001 Journal Drug Saf Section Abstract Doc Link 11772146 Disease Relevance 0.28 Pain Relevance 1.03
After induction of a hindpaw inflammation, several dorsal horn neurons express cyclo-oxygenase-2.
Gene_expression (express) of cyclo-oxygenase-2 in neurons associated with inflammation and dorsal horn neuron
6) Confidence 0.43 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.25 Pain Relevance 0.52
It is shown in the present study that both cyclo-oxygenase isoforms are constitutively expressed in the spinal cord, cyclo-oxygenase-1 in glial cells of the dorsal and ventral horns and cyclo-oxygenase-2 in motoneurons.
Gene_expression (expressed) of cyclo-oxygenase-2 in dorsal associated with spinal cord
7) Confidence 0.43 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.31 Pain Relevance 0.67
They are produced by cyclo-oxygenase isoforms, cyclo-oxygenase-1 and -2, which are both constitutively expressed in the central nervous system.
Gene_expression (expressed) of cyclo-oxygenase-1 and -2 in central nervous system associated with central nervous system
8) Confidence 0.38 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.24 Pain Relevance 0.39
LTP is normal in mice that lack HO-2 and, furthermore, there is no obvious mechanism by which HO could be activated during synaptic stimulation.
Neg (lack) Gene_expression (lack) of HO-2
9) Confidence 0.36 Published 1998 Journal Essays Biochem. Section Abstract Doc Link 10488443 Disease Relevance 0.09 Pain Relevance 0.15
They are produced by cyclo-oxygenase isoforms, cyclo-oxygenase-1 and -2, which are both constitutively expressed in the central nervous system.
Gene_expression (expressed) of cyclo-oxygenase-1 and -2 in central nervous system associated with central nervous system
10) Confidence 0.33 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.24 Pain Relevance 0.39
It was also observed that mice lacking expression of heme oxygenase type 2, an isozyme of heme oxygenase found in high abundance in the spinal cord, had lowered Fos expression after the formalin injection.
Gene_expression (expression) of oxygenase type 2 in spinal cord associated with spinal cord
11) Confidence 0.27 Published 2001 Journal Neuroscience Section Abstract Doc Link 11530233 Disease Relevance 0.38 Pain Relevance 0.58
Additional confocal microscopy studies demonstrated widespread expression of heme oxygenase type 2 in spinal cord neuron cell bodies.
Gene_expression (expression) of oxygenase type 2 in spinal cord neuron associated with spinal cord
12) Confidence 0.27 Published 2001 Journal Neuroscience Section Abstract Doc Link 11530233 Disease Relevance 0.35 Pain Relevance 0.60
The roles of HO in many pain models have been examined with changes in the expression of the spinal cord HO-2 isoform reported for both neuropathic and incisional pain models, though always studied apart from other CO/NO-cGMP signaling system components [1-4].
Gene_expression (expression) of HO-2 in spinal cord associated with pain, neuropathic pain and spinal cord
13) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.75 Pain Relevance 0.53
It is shown in the present study that both cyclo-oxygenase isoforms are constitutively expressed in the spinal cord, cyclo-oxygenase-1 in glial cells of the dorsal and ventral horns and cyclo-oxygenase-2 in motoneurons.
Gene_expression (expressed) of cyclo-oxygenase-2 in ventral associated with spinal cord
14) Confidence 0.15 Published 2000 Journal Neuroscience Section Abstract Doc Link 11113358 Disease Relevance 0.31 Pain Relevance 0.67
Notably, MOR(EtOH) attenuated the expression of cyclo-oxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) and neutrophil infiltration in paw tissues injected with carrageenan.
Gene_expression (expression) of cyclo-oxygenase 2 in paw
15) Confidence 0.09 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19576980 Disease Relevance 0 Pain Relevance 0
This compound exerted acute and chronic anti-inflammatory effects by oral route, that may be related with several mechanisms such as attenuation of leukocyte activation, inhibition of inducible nitric oxide synthase, cyclo-oxygenase-2 and cytosolic phospholipase A(2) expression as well as reduction in tumour necrosis factor-alpha production.
Gene_expression (expression) of cyclo-oxygenase-2 in leukocyte associated with necrosis, inflammation and cancer
16) Confidence 0.05 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12732367 Disease Relevance 0.53 Pain Relevance 0.32
This compound exerted acute and chronic anti-inflammatory effects by oral route, that may be related with several mechanisms such as attenuation of leukocyte activation, inhibition of inducible nitric oxide synthase, cyclo-oxygenase-2 and cytosolic phospholipase A(2) expression as well as reduction in tumour necrosis factor-alpha production.
Gene_expression (expression) of cyclo-oxygenase-2 in leukocyte associated with necrosis, inflammation and cancer
17) Confidence 0.05 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12732367 Disease Relevance 0.53 Pain Relevance 0.32
However, cytokines can also affect DA-cells by inducing enzymes such as nitric oxide synthase, cyclo-oxygenase 2, and NADPH-oxidase which produce toxic reactive species (Hunot et al., 1996; Knott et al., 2000).
Gene_expression (produce) of cyclo-oxygenase 2 associated with cytokine
18) Confidence 0.00 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.97 Pain Relevance 0.20

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