INT84111

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 22
Disease Relevance 0.43
Pain Relevance 7.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNC1) transmembrane transport (KCNC1)
Anatomy Link Frequency
bone marrow 3
fibroblasts 2
neural 2
neurons 2
ovary 2
KCNC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 227 100.00 Very High Very High Very High
potassium channel 53 100.00 Very High Very High Very High
sodium channel 48 100.00 Very High Very High Very High
antidepressant 1 99.80 Very High Very High Very High
Calcium channel 36 99.40 Very High Very High Very High
Neuronal excitability 3 99.40 Very High Very High Very High
fluoxetine 12 99.02 Very High Very High Very High
Pain 27 98.88 Very High Very High Very High
addiction 13 75.20 Quite High
Action potential 12 53.44 Quite High
Disease Link Frequency Relevance Heat
Pain 3 95.60 Very High Very High Very High
Tinnitus 2 80.60 Quite High
Obesity 228 75.00 Quite High
Injury 14 14.08 Low Low
Apoptosis 4 11.76 Low Low
Disease 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low
Fibrosis 2 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of fluoxetine (Prozac), a widely used antidepressant drug, on Kv1.3 stably expressed in Chinese hamster ovary cells were examined using the whole-cell and excised inside-out configurations of the patch-clamp technique.
Gene_expression (expressed) of Kv1 in ovary associated with antidepressant and fluoxetine
1) Confidence 0.58 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10490879 Disease Relevance 0 Pain Relevance 0.50
In the RT-PCR analysis, Kv1.1, Kv4.2, Kv1.4, Kir2.1, heag1, MaxiK, hNE-Na, and TWIK-1 were detected.
Gene_expression (detected) of Kv4
2) Confidence 0.55 Published 2007 Journal Stem Cells Section Abstract Doc Link 17525238 Disease Relevance 0 Pain Relevance 0.10
METHODS: Patch-clamp recordings were performed on the pharmacologic action of lidocaine on Kv 3.1 channels natively expressed in SH-SY5Y cells and Kv 1.1 channels expressed in HEK 293 cells.
Gene_expression (expressed) of Kv 3.1 in SH-SY5Y
3) Confidence 0.54 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0.08 Pain Relevance 0
The small effect at clinically relevant concentrations suggests that the physiologic roles of Kv 3.1 and Kv 1.1 channels in auditory neurons seem not to be impaired during the therapeutic or diagnostic application of lidocaine in the auditory system.


Gene_expression (roles) of Kv 3.1 in auditory system
4) Confidence 0.54 Published 2006 Journal Otol. Neurotol. Section Body Doc Link 16371858 Disease Relevance 0 Pain Relevance 0
However, this study indicates that primary hADSCs also express ion channel mRNAs, including potassium channel genes (MaxiK, Kv1.4, Kv4.2, and Eag2), calcium channel genes (CACNA1C and CACN1G), and the TTX-insensitive sodium channel gene (SCN5A), but do not exhibit the TTX-sensitive sodium channel gene (NE-Na) and other voltage-dependent potassium channel genes (Kv4.3 and Eag1) (Figure 4d).
Gene_expression (express) of Kv4 associated with tetrodotoxin, calcium channel, sodium channel and potassium channel
5) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.67
The primary hADSCs expressed MaxiK (responsible for human large-conductance, voltage- and calcium-dependent K+ channel), Kv1.4 and Kv4.2 (human voltage-dependent K+ channel), Eag2 (human ether-á-go-go K+ channel), SCN5A (TTX-insensitive Na+ channel), CACNA1C (human voltage-dependent L-type Ca2+ channel, alpha 1C subunit), and CACNA1G (human voltage-dependent T-type Ca2+ channel, alpha 1G subunit) constitutively.
Gene_expression (expressed) of Kv1 associated with tetrodotoxin
6) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.36
Following neural differentiation with bFGF and forskolin, the gene expression levels of MaxiK, Kv4.2, Eag2, SCN5A, CACNA1C, and CACNA1G in NI-hADSCs were significantly higher than in the primary hADSCs (Figure 4d, 4e).
Gene_expression (expression) of Kv4 in neural
7) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.20
However, primary hADSCs did not express Kv4.3 (human voltage-dependent K+ channel), Eag1 (human ether-á-go-go K+ channel), or NE-Na (TTX-sensitive Na+ channel).
Gene_expression (express) of Kv4 associated with tetrodotoxin
8) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.32
The primary hADSCs expressed MaxiK (responsible for human large-conductance, voltage- and calcium-dependent K+ channel), Kv1.4 and Kv4.2 (human voltage-dependent K+ channel), Eag2 (human ether-á-go-go K+ channel), SCN5A (TTX-insensitive Na+ channel), CACNA1C (human voltage-dependent L-type Ca2+ channel, alpha 1C subunit), and CACNA1G (human voltage-dependent T-type Ca2+ channel, alpha 1G subunit) constitutively.
Gene_expression (expressed) of Kv4 associated with tetrodotoxin
9) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.37
Following neural differentiation with bFGF and forskolin, the gene expression levels of MaxiK, Kv4.2, Eag2, SCN5A, CACNA1C, and CACNA1G in NI-hADSCs were significantly higher than in the primary hADSCs (Figure 4d, 4e).
Gene_expression (levels) of Kv4 in neural
10) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.18
Further examination by RT-PCR showed that NI-hADSCs expressed high level of ionic channel genes for sodium (SCN5A), potassium (MaxiK, Kv4.2, and EAG2), and calcium channels (CACNA1C and CACNA1G), which were expressed constitutively in the primary hADSCs.
Gene_expression (expressed) of Kv4 associated with calcium channel
11) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Abstract Doc Link PMC2867791 Disease Relevance 0.19 Pain Relevance 0.40
However, this study indicates that primary hADSCs also express ion channel mRNAs, including potassium channel genes (MaxiK, Kv1.4, Kv4.2, and Eag2), calcium channel genes (CACNA1C and CACN1G), and the TTX-insensitive sodium channel gene (SCN5A), but do not exhibit the TTX-sensitive sodium channel gene (NE-Na) and other voltage-dependent potassium channel genes (Kv4.3 and Eag1) (Figure 4d).
Gene_expression (express) of Kv1 associated with tetrodotoxin, calcium channel, sodium channel and potassium channel
12) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.67
Undifferentiated bone marrow-derived hMSCs are known to express the TTX-sensitive sodium channel gene (NE-Na), potassium channel genes (MaxiK, Kv1.4, Kv4.2, Kv4.3, and Eag1) and the calcium channel gene (CACNA1C) [56,57].
Gene_expression (express) of Kv1 in bone marrow associated with tetrodotoxin, calcium channel, sodium channel and potassium channel
13) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.59
Furthermore NI-hADSCs expressed Kv4.3, Eag1, and NE-Na.
Gene_expression (expressed) of Kv4
14) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.17
Undifferentiated bone marrow-derived hMSCs are known to express the TTX-sensitive sodium channel gene (NE-Na), potassium channel genes (MaxiK, Kv1.4, Kv4.2, Kv4.3, and Eag1) and the calcium channel gene (CACNA1C) [56,57].
Gene_expression (express) of Kv4 in bone marrow associated with tetrodotoxin, calcium channel, sodium channel and potassium channel
15) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.59
Undifferentiated bone marrow-derived hMSCs are known to express the TTX-sensitive sodium channel gene (NE-Na), potassium channel genes (MaxiK, Kv1.4, Kv4.2, Kv4.3, and Eag1) and the calcium channel gene (CACNA1C) [56,57].
Gene_expression (express) of Kv4 in bone marrow associated with tetrodotoxin, calcium channel, sodium channel and potassium channel
16) Confidence 0.42 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0 Pain Relevance 0.60
METHODS: Kv4.3/KChIP2.2 cDNA was transiently expressed in Chinese hamster ovary cells.
Gene_expression (expressed) of Kv4 in ovary
17) Confidence 0.38 Published 2005 Journal Anesthesiology Section Body Doc Link 16192772 Disease Relevance 0 Pain Relevance 0
However, Ito (likely encoded by Kv4.2/Kv4.3) and IKDR (likely encoded by Kv1.5/Kv1.6) were present only in a small population of human cardiac fibroblasts (15% and 14%, respectively) (Figs. 1–3).
Gene_expression (present) of Kv4 in fibroblasts
18) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.07
However, Ito (likely encoded by Kv4.2/Kv4.3) and IKDR (likely encoded by Kv1.5/Kv1.6) were present only in a small population of human cardiac fibroblasts (15% and 14%, respectively) (Figs. 1–3).
Gene_expression (present) of Kv4 in fibroblasts
19) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2751830 Disease Relevance 0 Pain Relevance 0.07
The level of Kv1.4 expression is unknown in human sensory neurons innervating healthy or painful tissue.
Gene_expression (expression) of Kv1 in sensory neurons associated with pain
20) Confidence 0.12 Published 2007 Journal J Endod Section Abstract Doc Link 17804321 Disease Relevance 0 Pain Relevance 0.31

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