INT8413

Context Info Confidence 0.78 First Reported 1981 Last Reported 2010 Negated 5 Speculated 6 Reported most in Abstract Documents 248 Total Number 254 Disease Relevance 110.17 Pain Relevance 108.58

nuclear envelope (Ptgs1) aging (Ptgs1) Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) cytoplasm (Ptgs1) lipid binding (Ptgs1)

Anatomy Link Frequency spinal 11 spinal cord 11 brain 8 cerebellum 5 blood 4 Ptgs1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammation 496 100.00 aspirin 199 100.00 COX2 188 100.00 cOX1 118 100.00 COX-2 inhibitor 104 100.00 Analgesic 85 100.00 cytokine 79 100.00 antagonist 46 100.00 diclofenac 39 100.00 agonist 39 100.00

Disease Link Frequency Relevance Heat INFLAMMATION 701 100.00 Cancer 181 100.00 Adhesions 70 100.00 Necrosis 25 100.00 Cv Unclassified Under Development 14 99.92 Colon Cancer 102 99.88 Hyperalgesia 115 99.84 Schizophrenia 36 99.80 Atherosclerosis 7 99.80 Stress 185 99.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data are compatible with the hypothesis that the sensory abnormalities observed in patients with RP may depend on estradiol-induced changes in SPGN, resulting in a sympathetically-dependent production of cyclooxygenase products of arachidonic acid.

Gene_expression (production) of cyclooxygenase associated with congenital anomalies

1) Confidence 0.78 Published 1989 Journal Brain Res. Section Abstract Doc Link 2546646 Disease Relevance 0.78 Pain Relevance 0.65

Systemic acetylsalicylic acid and mefenamic acid, in doses known to produce cyclooxygenase inhibition, produced limited or no analgesia using a duodenal distension model and a behavioral scale for assessment.

Neg (inhibition) Gene_expression (produce) of cyclooxygenase associated with aspirin and analgesia

2) Confidence 0.78 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2780782 Disease Relevance 0.07 Pain Relevance 0.68

Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.

Gene_expression (expression) of cyclooxygenase in brain

3) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.47

This is consistent with the apparent impossibility for the expression of cyclooxygenase active protein from cyclooxygenase-3 mRNA in the rat.

Gene_expression (expression) of cyclooxygenase

4) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.05 Pain Relevance 0.34

Western blotting demonstrated general expression of cyclooxygenase-1 in test tissues and cyclooxygenase-2 within the brain and cerebellum.

Gene_expression (expression) of cyclooxygenase in brain

5) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.07 Pain Relevance 0.48

Reverse transcription-polymerase chain reaction analysis of aorta, brain, cerebellum, heart, and lung showed general expression of cyclooxygenase-1 and cyclooxygenase-3 mRNA and particular expression of cyclooxygenase-2 mRNA in brain and cerebellum.

Gene_expression (expression) of cyclooxygenase in lung

6) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.08 Pain Relevance 0.46

Reverse transcription-polymerase chain reaction analysis of aorta, brain, cerebellum, heart, and lung showed general expression of cyclooxygenase-1 and cyclooxygenase-3 mRNA and particular expression of cyclooxygenase-2 mRNA in brain and cerebellum.

Gene_expression (expression) of cyclooxygenase-3 mRNA in lung

7) Confidence 0.76 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15148345 Disease Relevance 0.08 Pain Relevance 0.48

The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.

Gene_expression (expression) of cyclooxygenase

8) Confidence 0.75 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22

By Northern analysis, only PGHS-2 is expressed by the immortalized rat osteoblastic cell line, Py1a, while only PGHS-1 is expressed by the rat osteosarcoma cell line, ROS 17/2.8.

Gene_expression (expressed) of PGHS-1 associated with osteoporosis and osteogenic sarcomas

9) Confidence 0.70 Published 1997 Journal J. Bone Miner. Res. Section Abstract Doc Link 9258749 Disease Relevance 0.36 Pain Relevance 0.55

A 5-week study was carried out in rats using a leukotriene biosynthesis inhibitor (MK-886; 3-[1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl]-2,2- dimethylpropanoic acid) at a dose of 300 mg.kg-1 x day-1, this being sufficient to produce > 90% inhibition of ex vivo leukotriene B4 synthesis in rat blood, and a cyclooxygenase inhibitor (indomethacin, 4 and 6 mg.kg-1 x day-1) to ascertain whether inhibition of leukotriene biosynthesis would potentiate or inhibit the toxicity associated with the administration of nonsteroidal anti-inflammatory drugs (NSAIDs), in particular the gastrointestinal damage.

Gene_expression (produce) of cyclooxygenase in blood associated with toxicity, inflammation and cinod

10) Confidence 0.67 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8143238 Disease Relevance 0.32 Pain Relevance 0.25

IMPLICATIONS: Spinal injection of the alpha2-adrenergic agonist clonidine and the cyclooxygenase inhibitor ketorolac results in a synergistic interaction for antinociception in normal animals, suggesting that the combination of these drugs will enhance rather than detract from the analgesia of either alone.

Gene_expression (injection) of cyclooxygenase in Spinal associated with antinociception, acular, agonist, analgesia and clonidine

11) Confidence 0.67 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12505951 Disease Relevance 0 Pain Relevance 1.88

Although both alpha2-adrenergic agonists and cyclooxygenase inhibitors produce analgesia, their exact sites of action and interaction remain unclear.

Gene_expression (produce) of cyclooxygenase associated with agonist and analgesia

12) Confidence 0.67 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 12505951 Disease Relevance 0 Pain Relevance 1.27

The potency difference is similar to that for inhibition of cyclooxygenase in brain tissue and supports the hypothesis that cyclooxygenase products are involved in prolonged spinal nociceptive transmission.

Gene_expression (products) of cyclooxygenase in spinal associated with nociception and potency

13) Confidence 0.67 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8050472 Disease Relevance 0.10 Pain Relevance 0.33

Furthermore, the effect of a high dose of 25 mg/kg of the S(+) enantiomer on release of cyclooxygenase products from the various tissues was much longer lasting than that of an identical dose of the R(-) enantiomer.

Gene_expression (products) of cyclooxygenase

14) Confidence 0.67 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1801061 Disease Relevance 0.22 Pain Relevance 0.10

With the S(+) enantiomer and the racemate dose-dependent inhibition of release of cyclooxygenase products of arachidonate metabolism in all tissues tested was observed, while release of leukotriene (LT) C4 was inhibited in gastric mucosa, but not in jejunum and lung.

Gene_expression (products) of cyclooxygenase in lung

15) Confidence 0.67 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1801061 Disease Relevance 0.10 Pain Relevance 0

In the present study, we examined the changes of cyclooxygenase-1 and cyclooxygenase-2 protein expression in several regions of the CNS associated with pain perception, and the role of spinal cyclooxygenase activity in the development of allodynia following nerve injury.

Gene_expression (expression) of cyclooxygenase-1 in spinal associated with pain, nervous system injury and allodynia

16) Confidence 0.67 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.72 Pain Relevance 0.54

In contrast, cyclooxygenase-1 protein was not detectable in any of the neural tissues examined one, three, and 14 days after nerve injury.

Neg (not) Gene_expression (detectable) of cyclooxygenase-1 protein in neural associated with nervous system injury

17) Confidence 0.67 Published 2000 Journal Neuroscience Section Abstract Doc Link 10842019 Disease Relevance 0.97 Pain Relevance 0.81

Effects of cyclooxygenase products of arachidonic acid metabolism on cutaneous nociceptive threshold in the rat.

Gene_expression (products) of cyclooxygenase associated with nociception and nociceptor

18) Confidence 0.66 Published 1990 Journal Brain Res. Section Title Doc Link 2128200 Disease Relevance 0.61 Pain Relevance 0.59

The edema was accompanied by an increase in 5-lipoxygenase products, and the hyperalgesia coincided with the formation of both cyclooxygenase and 5-lipoxygenase products.

Gene_expression (products) of cyclooxygenase associated with pressure and volume under development and hyperalgesia

19) Confidence 0.66 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3103625 Disease Relevance 0.61 Pain Relevance 0.51

MATERIALS AND METHODS: Cerebral infarcted rats underwent cumulative intravenous administration of the selective cyclooxygenase-1 inhibitor SC-560 (Sigma), the selective cyclooxygenase-2 inhibitor rofecoxib (Kemprotec, Middlesbrough, United Kingdom) or the nonselective cyclooxygenase inhibitor FYO-750 hourly plus a single intravenous administration of SC-560, rofecoxib or SC-560 plus rofecoxib.

Gene_expression (selective) of cyclooxygenase-1

20) Confidence 0.66 Published 2010 Journal J. Urol. Section Body Doc Link 20022033 Disease Relevance 0.19 Pain Relevance 0

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