INT84162

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 5.05
Pain Relevance 7.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNMA1) transmembrane transport (KCNMA1)
Anatomy Link Frequency
myometrium 5
neuronal 1
peripheral nerve 1
external 1
vestibule 1
KCNMA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 33 100.00 Very High Very High Very High
nav1.8 10 100.00 Very High Very High Very High
Paroxysmal extreme pain disorder 64 99.44 Very High Very High Very High
lidocaine 1 98.76 Very High Very High Very High
Pain 40 98.34 Very High Very High Very High
Analgesic 8 98.34 Very High Very High Very High
IPN 4 98.24 Very High Very High Very High
local anesthetic 22 98.00 Very High Very High Very High
tetrodotoxin 181 97.80 Very High Very High Very High
depression 1 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Somatoform Disorder 64 99.44 Very High Very High Very High
Neuropathic Pain 6 98.88 Very High Very High Very High
Inflammatory Pain 4 98.24 Very High Very High Very High
Depression 1 96.48 Very High Very High Very High
Pain 41 95.40 Very High Very High Very High
Heart Arrhythmia 10 95.12 Very High Very High Very High
Erythermalgia 62 94.32 High High
Channelopathies 8 94.04 High High
INFLAMMATION 3 93.60 High High
Ganglion Cysts 66 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We utilized the RNAi methodology to investigate the selenium response under reduced expression levels of KCNMA1 (the most significant candidate) in PC3 as well as in LNCaP cell lines.
Negative_regulation (reduced) of KCNMA1
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.09 Pain Relevance 0
Our findings here suggest that, in human myometrium at labour onset, in addition to decreased Maxi-K ?
Negative_regulation (decreased) of Maxi-K in myometrium
2) Confidence 0.51 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
RNA interference (RNAi) experiments showed that the down regulation of one of these genes (KCNMA1) increased sensitivity to selenium in both selenium sensitive (LNCaP) and resistant (PC3) cell lines.


Negative_regulation (regulation) of KCNMA1
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.21 Pain Relevance 0.04
The siRNA knockdown of KCNMA1 has shown increased sensitivity to selenium treatment with all the probes where statistical significance was obtained with K7 in LNCaP (p?
Negative_regulation (knockdown) of KCNMA1
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.06 Pain Relevance 0
Pharmacological inhibition of Maxi-K channels, by the specific channel blocker iberiotoxin, increases contractile activity in human uterine tissue [5], whereas compounds that promote Maxi-K channel opening, such as NS1619, have a potent relaxant effect on pregnant human myometrium [6].
Negative_regulation (inhibition) of Maxi-K in myometrium
5) Confidence 0.38 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0.06 Pain Relevance 0
Song et al. [26] identified a decrease in Maxi-K ?
Negative_regulation (decrease) of Maxi-K
6) Confidence 0.38 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC524189 Disease Relevance 0 Pain Relevance 0
GsMTx-4 has been reported to be a specific stretch-activated channel inhibitor [31], [32], while L-methionine and fluphenazine show reasonable selectivity as TREK channel antagonists [17], [33], [34].


Negative_regulation (inhibitor) of channel associated with antagonist
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.05
These results may reflect distinctions in the manner of channel inhibition by these agents.
Negative_regulation (inhibition) of channel
8) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.05 Pain Relevance 0.03
GsMTx-4 has been reported to be a specific stretch-activated channel inhibitor [31], [32], while L-methionine and fluphenazine show reasonable selectivity as TREK channel antagonists [17], [33], [34].


Negative_regulation (inhibitor) of stretch-activated associated with antagonist
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0.05
Heating-induced contractions were potentiated by the K-channel inhibitors tetraethylammonium, BaCl2, charybdotoxin, and the Na+/K+ ATPase inhibitor ouabain.
Negative_regulation (inhibitors) of K-channel
10) Confidence 0.04 Published 2005 Journal J Stroke Cerebrovasc Dis Section Abstract Doc Link 17904011 Disease Relevance 0.44 Pain Relevance 0.16
Inhibition of Stretch-Activated Channels Stimulates Myometrial Contractions
Negative_regulation (Inhibition) of Stretch-Activated
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.07 Pain Relevance 0
The stretch-activated channel toxin (GsM Tx-4) and the TREK-1 more selective channel inhibitors methionine ethyl ester and fluphenazine altered myometrial tension and contractile frequency consistent with the activity of TREK-1 currents in pregnancy myometrium.
Negative_regulation (inhibitors) of channel in myometrium
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.07 Pain Relevance 0.13
Increasing concentrations of GsMTx-4 (Grammostola spatulata mechanotoxin-4), a specific mechanosensitive channel blocker [35], amplified oxytocin (1 ┬ÁM; OT) induced contractions in non-laboring pregnant myometrium.
Negative_regulation (blocker) of channel in myometrium
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0 Pain Relevance 0
To verify the significance of stretch-activated channels to the physiological function of the myometrium, we explored the effects of inhibiting stretch-activated channels.
Negative_regulation (inhibiting) of stretch-activated in myometrium
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2928262 Disease Relevance 0.06 Pain Relevance 0
Prenylamine block of Nav1.5 channel is mediated via a receptor distinct from that of local anesthetics.
Negative_regulation (block) of channel associated with local anesthetic
15) Confidence 0.03 Published 2002 Journal Mol. Pharmacol. Section Title Doc Link 12130695 Disease Relevance 0 Pain Relevance 0.55
Using whole-cell voltage clamp, we examined mibefradil block of four Na+ channel isoforms expressed in human embryonic kidney cells: Nav1.5 (cardiac), Nav1.4 (skeletal muscle), Nav1.2 (brain), and Nav1.7 (peripheral nerve).
Spec (examined) Negative_regulation (block) of channel in peripheral nerve associated with nav1.2 and nav1.7
16) Confidence 0.03 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562257 Disease Relevance 0 Pain Relevance 0.27
Pharmacological analysis showed TRESK to be inhibited by previously reported K+ channel inhibitors Ba2+, propafenone, glyburide, lidocaine, quinine, quinidine, and triethanolamine.
Negative_regulation (inhibitors) of channel associated with lidocaine
17) Confidence 0.02 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12754259 Disease Relevance 0 Pain Relevance 0.25
Here, we report that external acidification, within the physiological range, strongly inhibits the human K2P2.1 channel by inducing "C-type" closure.
Negative_regulation (inhibits) of channel in external
18) Confidence 0.02 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18474599 Disease Relevance 0.19 Pain Relevance 0.32
Inhibition of hKv2.1, a major human neuronal voltage-gated K+ channel, by meclofenamic acid.
Negative_regulation (Inhibition) of channel in neuronal
19) Confidence 0.01 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10493112 Disease Relevance 0.09 Pain Relevance 0.14
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
Negative_regulation (blockers) of channel associated with analgesic, ipn, neuropathic pain, sodium channel and nav1.8
20) Confidence 0.01 Published 2008 Journal J. Med. Chem. Section Title Doc Link 18176998 Disease Relevance 0.46 Pain Relevance 1.89

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