INT84170

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 58
Total Number 59
Disease Relevance 48.79
Pain Relevance 32.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 10
neurons 8
macrophage 6
nerve 6
DRG 6
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1255 100.00 Very High Very High Very High
Inflammation 738 100.00 Very High Very High Very High
dorsal root ganglion 338 100.00 Very High Very High Very High
Pain 315 100.00 Very High Very High Very High
Neuropathic pain 310 100.00 Very High Very High Very High
cytokine 206 100.00 Very High Very High Very High
agonist 9 100.00 Very High Very High Very High
central pain 2 99.90 Very High Very High Very High
Sciatic nerve 184 99.84 Very High Very High Very High
Spinal cord 180 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 874 100.00 Very High Very High Very High
Neuropathic Pain 441 100.00 Very High Very High Very High
Ganglion Cysts 348 100.00 Very High Very High Very High
Nervous System Injury 425 99.98 Very High Very High Very High
Hyperoxia 98 99.98 Very High Very High Very High
Experimental Diabetes Mellitus 3 99.98 Very High Very High Very High
Pain 413 99.90 Very High Very High Very High
Injury 439 99.82 Very High Very High Very High
Ureteral Obstruction 90 99.76 Very High Very High Very High
Demyelinating Disease 406 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral inflammation increases Scya2 expression in sensory ganglia and cytokine and endothelial related gene expression in inflamed tissue.
Positive_regulation (increases) of Gene_expression (expression) of Scya2 in ganglia associated with inflammation and cytokine
1) Confidence 0.69 Published 2007 Journal J. Neurochem. Section Title Doc Link 17883394 Disease Relevance 0.82 Pain Relevance 0.76
Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain.
Spec (possible) Positive_regulation (Enhanced) of Gene_expression (production) of chemoattractant protein-1 in dorsal root ganglia associated with pain and neuropathic pain
2) Confidence 0.60 Published 2004 Journal Neurosci. Res. Section Title Doc Link 15041200 Disease Relevance 0.50 Pain Relevance 0.78
Stimulation by a TRPV1 agonist, resiniferatoxin increased expression of Scya2 mRNA.
Positive_regulation (increased) of Gene_expression (expression) of Scya2 mRNA associated with agonist
3) Confidence 0.59 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.85 Pain Relevance 0.63
Nerve injury promotes the expression of MCP-1 in DRG cells [44] and it is possible that it is released centrally in neuropathic pain states.
Positive_regulation (promotes) of Gene_expression (expression) of MCP-1 in Nerve associated with dorsal root ganglion, nervous system injury and neuropathic pain
4) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2799401 Disease Relevance 1.80 Pain Relevance 1.20
Force-dependent development of neuropathic central pain and time-related CCL2/CCR2 expression after graded spinal cord contusion injuries of the rat.
Positive_regulation (time-related) of Gene_expression (expression) of CCL2 in spinal cord associated with pain, central pain, inflammation, injury, neuropathic pain and spinal cord
5) Confidence 0.50 Published 2008 Journal J. Neurotrauma Section Title Doc Link 18338959 Disease Relevance 1.44 Pain Relevance 1.19
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Positive_regulation (upregulation) of Gene_expression (production) of MCP-1 in neurons
6) Confidence 0.50 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.41 Pain Relevance 0.67
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Positive_regulation (upregulated) of Gene_expression (expression) of MCP-1 in neurons
7) Confidence 0.50 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.44 Pain Relevance 0.70
Additionally, increased MCP-1 in both intact L4 and injured L5 DRG neurons may contribute to neuropathic pain hypersensitivity following L5 SNL.
Positive_regulation (increased) of Gene_expression (neurons) of MCP-1 in DRG associated with dorsal root ganglion, hypersensitivity, neuropathic pain and stimulus evoked pain
8) Confidence 0.50 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.54 Pain Relevance 1.06
Despite increased MCP-1 in small and large DRG neurons, a remarkable increase in MCP-1-IR terminals was observed in the spinal superficial laminae following CCI and L5SNL, but not following axotomy; however, in the deeper laminae, a considerable increase in MCP-1-IR terminals, which may originate from the large and injured L5 DRG neurons, was found after L5 SNL.
Positive_regulation (increased) of Gene_expression (neurons) of MCP-1 in DRG associated with dorsal root ganglion and eae
9) Confidence 0.50 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.44 Pain Relevance 1.13
The production of MCP-1 was increased in synoviocytes treated with IL-1?.
Positive_regulation (increased) of Gene_expression (production) of MCP-1
10) Confidence 0.49 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.73 Pain Relevance 0.52
The jejunal muscularis was studied for cytokine mRNA expressions [interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, inducible nitric oxide synthase, cyclooxygenase-2, biliverdin, IL-10, and HO-1] using real-time RT-PCR.
Positive_regulation (inducible) of Gene_expression (expressions) of monocyte chemoattractant protein in monocyte associated with cytokine
11) Confidence 0.49 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16537973 Disease Relevance 0.68 Pain Relevance 0.35
The most prominent induction was detected for osteopontin and MCP-1.
Positive_regulation (induction) of Gene_expression (detected) of MCP-1
12) Confidence 0.46 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.33 Pain Relevance 0
-induced MCP-1 production.
Positive_regulation (induced) of Gene_expression (production) of MCP-1
13) Confidence 0.46 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.71 Pain Relevance 0.54
In a previous study, it was shown that in a rodent model of spinal stenosis, chronic compression of the DRG, there was increased MCP-1 expression and increased excitability of sensory neurons in injured and adjacent uninjured DRG [8].
Positive_regulation (increased) of Gene_expression (expression) of MCP-1 in spinal associated with spinal stenosis
14) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.41 Pain Relevance 0.18
Using immunocyctochemistry, we examined both the nerve lesion site and lumbar DRG associated with the injured nerve for MCP-1/CCL2 protein expression.
Positive_regulation (nerve) of Gene_expression (expression) of MCP-1 in nerve
15) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.50 Pain Relevance 0.33
We have observed that chemokines expressed by DRG neurons, including MCP1, IP10 and SDF1, can be packaged into secretory vesicles and released upon depolarization [9].
Positive_regulation (packaged) of Gene_expression (expressed) of MCP1 in vesicles associated with chemokine
16) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.29 Pain Relevance 0.58
Using immunocyctochemistry, we examined both the nerve lesion site and lumbar DRG associated with the injured nerve for MCP-1/CCL2 protein expression.
Positive_regulation (nerve) of Gene_expression (expression) of CCL2 in nerve
17) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.50 Pain Relevance 0.33
For all experiments, MCP-1, SDF1, RANTES and IP10 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (experiments) of Gene_expression (added) of MCP-1 associated with qutenza
18) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.09 Pain Relevance 0.27
Moreover, our results confirm and extend previous reports of increased MCP-1 expression in the kidney in diabetes [8-12] and in hypertension [3].
Positive_regulation (increased) of Gene_expression (expression) of MCP-1 in kidney associated with diabetes mellitus and hypertension
19) Confidence 0.43 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.14 Pain Relevance 0.03
Streptozotocin diabetes induced some predominantly glomerular MCP-1 expression and macrophage infiltration whereas hypertensive rats exhibited marked interstitial and glomerular inflammation.
Positive_regulation (induced) of Gene_expression (expression) of MCP-1 in macrophage associated with inflammation, experimental diabetes mellitus and hypertension
20) Confidence 0.43 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1175090 Disease Relevance 1.32 Pain Relevance 0.05

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