INT84171

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 26.37
Pain Relevance 18.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
spinal 12
macrophages 11
monocyte 8
endothelial cells 7
T cells 6
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 515 100.00 Very High Very High Very High
Inflammation 365 100.00 Very High Very High Very High
allodynia 23 100.00 Very High Very High Very High
dorsal root ganglion 21 100.00 Very High Very High Very High
Neuropathic pain 122 99.92 Very High Very High Very High
cytokine 85 99.84 Very High Very High Very High
spinal stenosis 12 99.20 Very High Very High Very High
Stimulus evoked pain 24 98.96 Very High Very High Very High
Sciatic nerve 86 98.20 Very High Very High Very High
diclofenac 18 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 469 100.00 Very High Very High Very High
Neuropathic Pain 173 100.00 Very High Very High Very High
Adhesions 35 100.00 Very High Very High Very High
Ganglion Cysts 25 100.00 Very High Very High Very High
Nervous System Injury 182 99.64 Very High Very High Very High
Necrosis 18 99.40 Very High Very High Very High
Spinal Stenosis 12 99.20 Very High Very High Very High
Cancer 12 99.04 Very High Very High Very High
Pain 149 98.96 Very High Very High Very High
Hypersensitivity 42 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spinal expression of MCP-1 peaked when mechanical allodynia was maximal, but then declined rapidly despite the remarkable persistence of mechanical allodynia.
Negative_regulation (declined) of Gene_expression (expression) of MCP-1 in Spinal associated with allodynia
1) Confidence 0.58 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.38 Pain Relevance 0.99
The in vitro study revealed that CM inhibited both MCP-1 and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs.
Negative_regulation (inhibited) of Gene_expression (production) of MCP-1 in monocytes
2) Confidence 0.56 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.70 Pain Relevance 0.35
The targeted blockade of JAK/STAT3 activity prevented the abnormal expression of IL-6, CC chemokine ligand CCL2, and activating transcription factor ATF3 induced in the spinal cord by chronic constriction injury of the sciatic nerve (CCI) and substantially attenuated mechanical hypersensitivity (allodynia) in rats.
Negative_regulation (prevented) of Gene_expression (expression) of CCL2 in CCI associated with chemokine, allodynia, eae, hypersensitivity, injury, sciatic nerve and spinal cord
3) Confidence 0.43 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.80 Pain Relevance 1.11
Spinal expression of MCP-1 peaked when mechanical allodynia was maximal, but then declined rapidly despite the remarkable persistence of mechanical allodynia.
Negative_regulation (declined) of Gene_expression (expression) of MCP-1 in Spinal associated with allodynia
4) Confidence 0.42 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.38 Pain Relevance 0.99
MCP-1 expression in the DRG peaked and declined before the full onset of pain hypersensitivity following nerve injury.
Negative_regulation (declined) of Gene_expression (expression) of MCP-1 in DRG associated with dorsal root ganglion, nervous system injury, hypersensitivity and stimulus evoked pain
5) Confidence 0.42 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.23 Pain Relevance 0.91
The in vitro study revealed that CM inhibited both MCP-1 and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs.
Negative_regulation (inhibited) of Gene_expression (production) of MCP-1 in monocytes
6) Confidence 0.41 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 15531908 Disease Relevance 0.70 Pain Relevance 0.35
Indeed, we previously demonstrated that in a rodent model of spinal stenosis, chronic compression of the DRG (CCD), produced a delayed but chronic expression of both the chemokine receptor CCR2 and its ligand, the chemokine MCP-1/CCL2 in lumbar DRGs [8].
Negative_regulation (delayed) of Gene_expression (expression) of CCL2 in spinal associated with chemokine and spinal stenosis
7) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 1.24 Pain Relevance 1.22
Indeed, we previously demonstrated that in a rodent model of spinal stenosis, chronic compression of the DRG (CCD), produced a delayed but chronic expression of both the chemokine receptor CCR2 and its ligand, the chemokine MCP-1/CCL2 in lumbar DRGs [8].
Negative_regulation (produced) of Gene_expression (expression) of CCL2 in spinal associated with chemokine and spinal stenosis
8) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 1.25 Pain Relevance 1.23
In our results we underline the relation between the absence of recruited macrophages and the absence of MCP-1 expression in the inflamed paws of intravenously oATP-treated rats.
Negative_regulation (absence) of Gene_expression (expression) of MCP-1 in macrophages
9) Confidence 0.35 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.10 Pain Relevance 0.17
Indeed, we previously demonstrated that in a rodent model of spinal stenosis, chronic compression of the DRG (CCD), produced a delayed but chronic expression of both the chemokine receptor CCR2 and its ligand, the chemokine MCP-1/CCL2 in lumbar DRGs [8].
Negative_regulation (delayed) of Gene_expression (expression) of chemokine MCP-1 in spinal associated with chemokine and spinal stenosis
10) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 1.24 Pain Relevance 1.22
Indeed, we previously demonstrated that in a rodent model of spinal stenosis, chronic compression of the DRG (CCD), produced a delayed but chronic expression of both the chemokine receptor CCR2 and its ligand, the chemokine MCP-1/CCL2 in lumbar DRGs [8].
Negative_regulation (produced) of Gene_expression (expression) of chemokine MCP-1 in spinal associated with chemokine and spinal stenosis
11) Confidence 0.32 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 1.25 Pain Relevance 1.23
Both B- and T-cell responses towards peripheral myelin were suppressed by the IFN-beta, and immunohistochemical analyses revealed a strong decrease in the numbers of infiltrating CD4(+) T cells, macrophages, and other inflammatory cells as well as a significant reduction in MHC class II antigen expression and monocyte chemotactic protein-1 (MCP-1) production, which induces chemotaxis and chemokinesis of leukocytes from blood.
Negative_regulation (reduction) of Gene_expression (production) of MCP-1 in T cells associated with inflammation
12) Confidence 0.30 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10494101 Disease Relevance 0.90 Pain Relevance 0.74
On the other hand, NO reduces MCP-1 expression in macrophages and endothelial cells [19,20] and leads to decreased expressions of cell adhesion molecules such as CD11, CD18, VCAM-1 (vascular cell adhesion molecule-1), and ICAM-1 (intercellular adhesion molecule-1) [21,22], counteracting an adhesion of monocytes to the activated endothelial lining.
Negative_regulation (reduces) of Gene_expression (expression) of MCP-1 in macrophages associated with adhesions
13) Confidence 0.30 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0.68 Pain Relevance 0.03
Both B- and T-cell responses towards peripheral myelin were suppressed by the IFN-beta, and immunohistochemical analyses revealed a strong decrease in the numbers of infiltrating CD4(+) T cells, macrophages, and other inflammatory cells as well as a significant reduction in MHC class II antigen expression and monocyte chemotactic protein-1 (MCP-1) production, which induces chemotaxis and chemokinesis of leukocytes from blood.
Negative_regulation (reduction) of Gene_expression (production) of chemotactic protein-1 in T cells associated with inflammation
14) Confidence 0.26 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10494101 Disease Relevance 0.90 Pain Relevance 0.74
Following oATP treatment, the expression of the pro-inflammatory chemokines interferon-gamma-inducible protein-10 (IP-10), mon ocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) within the inflamed tissues markedly decreased on vessels and infiltrated cells.
Negative_regulation (decreased) of Gene_expression (expression) of MCP-1 in vessels associated with chemokine and inflammation
15) Confidence 0.26 Published 2005 Journal BMC Immunol Section Abstract Doc Link PMC1190175 Disease Relevance 0.53 Pain Relevance 0.53
In particular, the abrogation of MCP-1 production by oATP could be related to the oATP-induced block of P2X7 function on activation of endothelial and immune cells, which can become ineffective to produce MCP-1.
Negative_regulation (abrogation) of Gene_expression (production) of MCP-1 in immune cells
16) Confidence 0.26 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.13 Pain Relevance 0.20
Compounds capable of blocking the intracellular calcium rise evoked by mouse CCL2 in HEK293 s cells (G?
Negative_regulation (blocking) of Gene_expression (evoked) of CCL2
17) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.27 Pain Relevance 0.49
In agreement with these studies, we found that MCP-1 production in pleural exudates is downregulated by NOC-18 or L-arginine and upregulated by NOS inhibitors.
Negative_regulation (downregulated) of Gene_expression (production) of MCP-1
18) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.36 Pain Relevance 0.29
In vitro studies have shown that NO donors (NONOate compounds) inhibit the expression and production of MCP-1 in cytokine-activated human endothelial cells [56].
Negative_regulation (inhibit) of Gene_expression (production) of MCP-1 in endothelial cells associated with cytokine
19) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.36 Pain Relevance 0.31
In vitro studies have shown that NO donors (NONOate compounds) inhibit the expression and production of MCP-1 in cytokine-activated human endothelial cells [56].
Negative_regulation (inhibit) of Gene_expression (expression) of MCP-1 in endothelial cells associated with cytokine
20) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2879545 Disease Relevance 0.36 Pain Relevance 0.31

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