INT84180
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Our findings are also in sharp contrast to the initial case control study reports of a strong association between FVL and pregnancy loss (e.g., ORs 4.9 with FVL and stillbirth) [41] but consistent with later meta-analyses [14]. | |||||||||||||||
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In their analysis of retrospective and prospective cohort studies, there was no evidence of association between FVL and SGA (<10th percentile) (n? | |||||||||||||||
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Budd-Chiari syndrome associated with visceral leishmaniasis and factor V Leiden mutation. | |||||||||||||||
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There were five studies reporting the association between FVL mutation and placenta abruption [32],[34],[36],[37],[39]. | |||||||||||||||
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There was no significant association between FVL and pre-eclampsia (OR? | |||||||||||||||
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Unfortunately small sample sizes and low event rates limit conclusions regarding an association between the inherited thrombophilias, FVL or PGM, and placenta abruption. | |||||||||||||||
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Maternal FVL/PGM and Severe SGA Neonate (Birth Weight <5th Percentile) | |||||||||||||||
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Maternal FVL/PGM and SGA Neonate (Birth Weight <10th Percentile) | |||||||||||||||
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There was no association between FVL and the composite outcome of any of the placenta-mediated pregnancy complications (pregnancy loss, placental abruption, pre-eclampsia, and SGA [>10th percentile]) with a pooled OR? | |||||||||||||||
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Maternal FVL/PGM and Placental Abruption | |||||||||||||||
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Women with FVL and PGM appear not to be at increased risk of pre-eclampsia or birth of SGA infants. | |||||||||||||||
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Maternal FVL/PGM and Pregnancy Loss | |||||||||||||||
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Finally, there was no significant association between either FVL or PGM and the composite outcome of any placenta-mediated pregnancy complication (pregnancy loss, pre-eclampsia, small for gestational age, and placental abruption).
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A recently published meta-analysis of case control and cohort studies identified a significant association between FVL and SGA (<10th percentile) in case control studies but identified evidence of publication bias in these case control studies [44]. | |||||||||||||||
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Only conception or prepregnancy prospective cohorts would permit prospective examination of this issue; (2) we had insufficient data and hence power to detect important associations between PGM and pregnancy loss as well as FVL or PGM and placental abruption; (3) there are insufficient prospective cohort studies examining the less common and more potent thrombophilias such as antithrombin, protein C, and protein S deficiencies to elucidate associations between these thrombophilias and placenta-mediated pregnancy complications. | |||||||||||||||
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Maternal FVL/PGM and Pre-eclampsia | |||||||||||||||
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The researchers identified ten prospective cohort studies that examined the association between FVL/PGM and placenta-mediated pregnancy complications and that met their predefined criteria. | |||||||||||||||
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Only a minority of F5 PTNs terminate in the lower cervical motor nuclei innervating digit muscles (He et al., 1993). | |||||||||||||||
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The fact that the binding of mMAbs was not affected by treating virus with 0.3% BPL, but binding of hMAb F5 was affected, suggests that epitopes recognized by the VEEV neutralizing mMAbs and hMAb F5 may not be the same. | |||||||||||||||
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In this case the VEEV TC-83 used for panning and screening was inactivated with 0.05% BPL; previously the virus used for these procedures was inactivated with 0.3% BPL, a concentration subsequently shown to reduce the binding of F5 eIgG and F5 nIgG (Table S2). | |||||||||||||||
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General Comments
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