INT84180

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Context Info
Confidence 0.48
First Reported 1999
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 22
Total Number 40
Disease Relevance 18.60
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F5) extracellular region (F5) cell adhesion (F5)
plasma membrane (F5)
Anatomy Link Frequency
placenta 6
visceral 1
muscles 1
platelets 1
F5 (Homo sapiens)
F5 - G1691A (1)
Pain Link Frequency Relevance Heat
cva 81 97.28 Very High Very High Very High
Pain 18 94.92 High High
abdominal pain 2 91.56 High High
imagery 18 73.40 Quite High
aspirin 26 5.00 Very Low Very Low Very Low
headache 18 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
epidural 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Togavirus Infection 2214 100.00 Very High Very High Very High
Thrombophilia 714 100.00 Very High Very High Very High
Hyperhomocysteinemia 15 100.00 Very High Very High Very High
Leishmaniasis 2 100.00 Very High Very High Very High
Anaemia 1 100.00 Very High Very High Very High
Budd-chiari Syndrome 6 99.98 Very High Very High Very High
Eclampsia 546 99.64 Very High Very High Very High
Abruptio Placentae 359 99.64 Very High Very High Very High
Pregnancy Complications 399 99.44 Very High Very High Very High
Birth Weight 139 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings are also in sharp contrast to the initial case control study reports of a strong association between FVL and pregnancy loss (e.g., ORs 4.9 with FVL and stillbirth) [41] but consistent with later meta-analyses [14].
FVL Binding (association) of
1) Confidence 0.48 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.11 Pain Relevance 0.06
In their analysis of retrospective and prospective cohort studies, there was no evidence of association between FVL and SGA (<10th percentile) (n?
FVL Neg (no) Binding (association) of
2) Confidence 0.41 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.44 Pain Relevance 0
Budd-Chiari syndrome associated with visceral leishmaniasis and factor V Leiden mutation.
factor V Leiden Binding (associated) of in visceral associated with leishmaniasis and budd-chiari syndrome
3) Confidence 0.37 Published 2004 Journal J. Thromb. Thrombolysis Section Title Doc Link 15815883 Disease Relevance 1.08 Pain Relevance 0.09
There were five studies reporting the association between FVL mutation and placenta abruption [32],[34],[36],[37],[39].
FVL Binding (association) of in placenta
4) Confidence 0.37 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.43 Pain Relevance 0
There was no significant association between FVL and pre-eclampsia (OR?
FVL Neg (no) Binding (association) of associated with eclampsia
5) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.80 Pain Relevance 0
Unfortunately small sample sizes and low event rates limit conclusions regarding an association between the inherited thrombophilias, FVL or PGM, and placenta abruption.
FVL Binding (association) of in placenta associated with thrombophilia
6) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.44 Pain Relevance 0
Maternal FVL/PGM and Severe SGA Neonate (Birth Weight <5th Percentile)
FVL Binding (Maternal) of associated with birth weight
7) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.24 Pain Relevance 0
Maternal FVL/PGM and SGA Neonate (Birth Weight <10th Percentile)
FVL Binding (Maternal) of associated with birth weight
8) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.73 Pain Relevance 0
There was no association between FVL and the composite outcome of any of the placenta-mediated pregnancy complications (pregnancy loss, placental abruption, pre-eclampsia, and SGA [>10th percentile]) with a pooled OR?
FVL Neg (no) Binding (association) of in placenta associated with abruptio placentae, pregnancy complications and eclampsia
9) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.89 Pain Relevance 0
Maternal FVL/PGM and Placental Abruption
FVL Binding (Maternal) of associated with abruptio placentae
10) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.37 Pain Relevance 0
Women with FVL and PGM appear not to be at increased risk of pre-eclampsia or birth of SGA infants.
FVL Binding (Women) of associated with eclampsia
11) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.70 Pain Relevance 0
Maternal FVL/PGM and Pregnancy Loss
FVL Binding (Maternal) of
12) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.15 Pain Relevance 0
Finally, there was no significant association between either FVL or PGM and the composite outcome of any placenta-mediated pregnancy complication (pregnancy loss, pre-eclampsia, small for gestational age, and placental abruption).


FVL Neg (no) Binding (association) of in placenta associated with abruptio placentae, pregnancy complications and eclampsia
13) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.96 Pain Relevance 0
A recently published meta-analysis of case control and cohort studies identified a significant association between FVL and SGA (<10th percentile) in case control studies but identified evidence of publication bias in these case control studies [44].
FVL Binding (association) of
14) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.56 Pain Relevance 0
Only “conception” or prepregnancy prospective cohorts would permit prospective examination of this issue; (2) we had insufficient data and hence power to detect important associations between PGM and pregnancy loss as well as FVL or PGM and placental abruption; (3) there are insufficient prospective cohort studies examining the less common and more potent thrombophilias such as antithrombin, protein C, and protein S deficiencies to elucidate associations between these thrombophilias and placenta-mediated pregnancy complications.
FVL Binding (associations) of in placenta associated with thrombophilia, abruptio placentae and pregnancy complications
15) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.50 Pain Relevance 0
Maternal FVL/PGM and Pre-eclampsia
FVL Binding (Maternal) of associated with eclampsia
16) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.49 Pain Relevance 0
The researchers identified ten prospective cohort studies that examined the association between FVL/PGM and placenta-mediated pregnancy complications and that met their predefined criteria.
FVL Spec (examined) Binding (association) of in placenta associated with pregnancy complications
17) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.79 Pain Relevance 0
Only a minority of F5 PTNs terminate in the lower cervical motor nuclei innervating digit muscles (He et al., 1993).
F5 Binding (minority) of in muscles
18) Confidence 0.12 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0 Pain Relevance 0
The fact that the binding of mMAbs was not affected by treating virus with 0.3% BPL, but binding of hMAb F5 was affected, suggests that epitopes recognized by the VEEV neutralizing mMAbs and hMAb F5 may not be the same.
hMAb F5 Binding (binding) of associated with togavirus infection
19) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.30 Pain Relevance 0
In this case the VEEV TC-83 used for panning and screening was inactivated with 0.05% BPL; previously the virus used for these procedures was inactivated with 0.3% BPL, a concentration subsequently shown to reduce the binding of F5 eIgG and F5 nIgG (Table S2).
F5 Binding (binding) of associated with togavirus infection
20) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.38 Pain Relevance 0

General Comments

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