INT84180

Context Info Confidence 0.48 First Reported 1999 Last Reported 2010 Negated 5 Speculated 1 Reported most in Body Documents 22 Total Number 40 Disease Relevance 18.60 Pain Relevance 0.49

extracellular space (F5) extracellular region (F5) cell adhesion (F5) plasma membrane (F5)

Anatomy Link Frequency placenta 6 visceral 1 muscles 1 platelets 1 F5 (Homo sapiens) F5 - G1691A (1)

Pain Link Frequency Relevance Heat cva 81 97.28 Pain 18 94.92 abdominal pain 2 91.56 imagery 18 73.40 aspirin 26 5.00 headache 18 5.00 anesthesia 3 5.00 epidural 3 5.00 Spinal cord 2 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Togavirus Infection 2214 100.00 Thrombophilia 714 100.00 Hyperhomocysteinemia 15 100.00 Leishmaniasis 2 100.00 Anaemia 1 100.00 Budd-chiari Syndrome 6 99.98 Eclampsia 546 99.64 Abruptio Placentae 359 99.64 Pregnancy Complications 399 99.44 Birth Weight 139 99.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our findings are also in sharp contrast to the initial case control study reports of a strong association between FVL and pregnancy loss (e.g., ORs 4.9 with FVL and stillbirth) [41] but consistent with later meta-analyses [14].

FVL Binding (association) of

1) Confidence 0.48 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.11 Pain Relevance 0.06

In their analysis of retrospective and prospective cohort studies, there was no evidence of association between FVL and SGA (<10th percentile) (n?

FVL Neg (no) Binding (association) of

2) Confidence 0.41 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.44 Pain Relevance 0

Budd-Chiari syndrome associated with visceral leishmaniasis and factor V Leiden mutation.

factor V Leiden Binding (associated) of in visceral associated with leishmaniasis and budd-chiari syndrome

3) Confidence 0.37 Published 2004 Journal J. Thromb. Thrombolysis Section Title Doc Link 15815883 Disease Relevance 1.08 Pain Relevance 0.09

There were five studies reporting the association between FVL mutation and placenta abruption [32],[34],[36],[37],[39].

FVL Binding (association) of in placenta

4) Confidence 0.37 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.43 Pain Relevance 0

There was no significant association between FVL and pre-eclampsia (OR?

FVL Neg (no) Binding (association) of associated with eclampsia

5) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.80 Pain Relevance 0

Unfortunately small sample sizes and low event rates limit conclusions regarding an association between the inherited thrombophilias, FVL or PGM, and placenta abruption.

FVL Binding (association) of in placenta associated with thrombophilia

6) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.44 Pain Relevance 0

Maternal FVL/PGM and Severe SGA Neonate (Birth Weight <5th Percentile)

FVL Binding (Maternal) of associated with birth weight

7) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.24 Pain Relevance 0

Maternal FVL/PGM and SGA Neonate (Birth Weight <10th Percentile)

FVL Binding (Maternal) of associated with birth weight

8) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.73 Pain Relevance 0

There was no association between FVL and the composite outcome of any of the placenta-mediated pregnancy complications (pregnancy loss, placental abruption, pre-eclampsia, and SGA [>10th percentile]) with a pooled OR?

FVL Neg (no) Binding (association) of in placenta associated with abruptio placentae, pregnancy complications and eclampsia

9) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.89 Pain Relevance 0

Maternal FVL/PGM and Placental Abruption

FVL Binding (Maternal) of associated with abruptio placentae

10) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.37 Pain Relevance 0

Women with FVL and PGM appear not to be at increased risk of pre-eclampsia or birth of SGA infants.

FVL Binding (Women) of associated with eclampsia

11) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.70 Pain Relevance 0

Maternal FVL/PGM and Pregnancy Loss

FVL Binding (Maternal) of

12) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.15 Pain Relevance 0

Finally, there was no significant association between either FVL or PGM and the composite outcome of any placenta-mediated pregnancy complication (pregnancy loss, pre-eclampsia, small for gestational age, and placental abruption).

FVL Neg (no) Binding (association) of in placenta associated with abruptio placentae, pregnancy complications and eclampsia

13) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.96 Pain Relevance 0

A recently published meta-analysis of case control and cohort studies identified a significant association between FVL and SGA (<10th percentile) in case control studies but identified evidence of publication bias in these case control studies [44].

FVL Binding (association) of

14) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.56 Pain Relevance 0

Only “conception” or prepregnancy prospective cohorts would permit prospective examination of this issue; (2) we had insufficient data and hence power to detect important associations between PGM and pregnancy loss as well as FVL or PGM and placental abruption; (3) there are insufficient prospective cohort studies examining the less common and more potent thrombophilias such as antithrombin, protein C, and protein S deficiencies to elucidate associations between these thrombophilias and placenta-mediated pregnancy complications.

FVL Binding (associations) of in placenta associated with thrombophilia, abruptio placentae and pregnancy complications

15) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.50 Pain Relevance 0

Maternal FVL/PGM and Pre-eclampsia

FVL Binding (Maternal) of associated with eclampsia

16) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC2885985 Disease Relevance 0.49 Pain Relevance 0

The researchers identified ten prospective cohort studies that examined the association between FVL/PGM and placenta-mediated pregnancy complications and that met their predefined criteria.

FVL Spec (examined) Binding (association) of in placenta associated with pregnancy complications

17) Confidence 0.32 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC2885985 Disease Relevance 0.79 Pain Relevance 0

Only a minority of F5 PTNs terminate in the lower cervical motor nuclei innervating digit muscles (He et al., 1993).

F5 Binding (minority) of in muscles

18) Confidence 0.12 Published 2009 Journal Neuron Section Body Doc Link PMC2862290 Disease Relevance 0 Pain Relevance 0

The fact that the binding of mMAbs was not affected by treating virus with 0.3% BPL, but binding of hMAb F5 was affected, suggests that epitopes recognized by the VEEV neutralizing mMAbs and hMAb F5 may not be the same.

hMAb F5 Binding (binding) of associated with togavirus infection

19) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.30 Pain Relevance 0

In this case the VEEV TC-83 used for panning and screening was inactivated with 0.05% BPL; previously the virus used for these procedures was inactivated with 0.3% BPL, a concentration subsequently shown to reduce the binding of F5 eIgG and F5 nIgG (Table S2).

F5 Binding (binding) of associated with togavirus infection

20) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.38 Pain Relevance 0

General Comments

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