INT8422

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Context Info
Confidence 0.37
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.54
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cntf) cytosol (Cntf) extracellular space (Cntf)
growth (Cntf) nucleus (Cntf) cytoplasm (Cntf)
Anatomy Link Frequency
muscles 2
aggregate cell 1
sciatic nerve 1
astrocytes 1
Cntf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 98.32 Very High Very High Very High
Neuropeptide 15 95.76 Very High Very High Very High
Sciatic nerve 2 93.48 High High
Somatostatin 9 93.20 High High
Central nervous system 85 93.12 High High
substance P 19 92.48 High High
intrathecal 1 91.72 High High
Dorsal column 90 90.64 High High
Spinal cord 282 90.44 High High
cerebral cortex 4 88.32 High High
Disease Link Frequency Relevance Heat
Injury 446 99.56 Very High Very High Very High
Myalgia 2 98.52 Very High Very High Very High
Cramps 6 97.44 Very High Very High Very High
Spinal Cord Injury 243 96.60 Very High Very High Very High
Multiple Sclerosis 3 91.72 High High
Optic Nerve Injuries 2 87.28 High High
Ganglion Cysts 25 84.32 Quite High
Disease 7 79.60 Quite High
Apoptosis 48 76.68 Quite High
Cicatrix 36 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At low doses, CNTF does not exert its myotrophic role over denervated muscles but clearly affects the excitable and contractile properties of innervated muscles.
CNTF Binding (affects) of in muscles
1) Confidence 0.37 Published 2003 Journal Biol. Res. Section Abstract Doc Link 14631864 Disease Relevance 0.73 Pain Relevance 0.20
At low doses, CNTF does not exert its myotrophic role over denervated muscles but clearly affects the excitable and contractile properties of innervated muscles.
CNTF Neg (not) Binding (exert) of in muscles
2) Confidence 0.37 Published 2003 Journal Biol. Res. Section Abstract Doc Link 14631864 Disease Relevance 0.73 Pain Relevance 0.20
Our findings that GDAsCNTF can become Olig2-negative after transplantation shows that the phenotype of such cells can be labile in vivo, as has also been seen in studies of Olig2+ astrocytes during CNS development [41].
GDAsCNTF Binding (findings) of in astrocytes associated with central nervous system
3) Confidence 0.30 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.66 Pain Relevance 0.30
Characterization of transplanted GDAsCNTF in vivo
GDAsCNTF Binding (Characterization) of
4) Confidence 0.30 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.51 Pain Relevance 0.07
GDAsCNTF do not support axon regeneration in vivo
GDAsCNTF Binding (regeneration) of
5) Confidence 0.30 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.18 Pain Relevance 0.20
These effects were abolished by immunoprecipitation of CNTF-like molecules from the extract with an antiserum raised against recombinant CNTF, and recombinant CNTF caused changes in neuropeptide levels similar to those of sciatic nerve extract.
CNTF Binding (immunoprecipitation) of in sciatic nerve associated with neuropeptide and sciatic nerve
6) Confidence 0.25 Published 1992 Journal Dev. Biol. Section Abstract Doc Link 1372570 Disease Relevance 0 Pain Relevance 0.55
In our analysis we also found an upregulation in Lifr, a receptor for LIF and a co-receptor for CNTF.
CNTF Binding (receptor) of
7) Confidence 0.14 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.66 Pain Relevance 0.20
It has been observed that ciliary neurotropic factor and IL-11 have no effect on PRL and GH secretion in monolayer cell cultures, but stimulate these secretions in aggregate cell culture (790).
neurotropic factor Binding (ciliary) of in aggregate cell
8) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0

General Comments

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