INT84222

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Context Info
Confidence 0.45
First Reported 1999
Last Reported 2008
Negated 1
Speculated 2
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.24
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Ednrb) signal transduction (Ednrb) plasma membrane (Ednrb)
signal transducer activity (Ednrb)
Anatomy Link Frequency
interneurons 1
Ednrb (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 14 100.00 Very High Very High Very High
antagonist 13 99.96 Very High Very High Very High
Clonidine 7 99.82 Very High Very High Very High
Inflammation 14 99.12 Very High Very High Very High
Hyperalgesia 8 98.28 Very High Very High Very High
Spinal cord 18 97.92 Very High Very High Very High
gABA 12 95.04 Very High Very High Very High
Action potential 8 94.96 High High
addiction 1 92.76 High High
substantia gelatinosa 57 90.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.12 Very High Very High Very High
Nociception 8 98.44 Very High Very High Very High
Hyperalgesia 9 98.28 Very High Very High Very High
Targeted Disruption 5 96.60 Very High Very High Very High
Pain 6 89.92 High High
Neuropathic Pain 2 89.24 High High
Ganglion Cysts 6 83.08 Quite High
Inflammatory Pain 4 75.00 Quite High
Nervous System Injury 2 68.00 Quite High
Pressure And Volume Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of endothelin B (ET(B)) receptors in inflammation and nociception was examined using ET(B) receptor knockout mice.
Spec (examined) Regulation (role) of endothelin B associated with targeted disruption, nociception and inflammation
1) Confidence 0.45 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10496965 Disease Relevance 0.49 Pain Relevance 0.27
We have studied the effect of ETA and ETB receptor antagonists in the thermal and mechanical hyperalgesia induced in a model of acute (induced by carrageenan) and chronic (induced by complete Freund's adjuvant, CFA) inflammation in mice.
Regulation (effect) of ETB receptor associated with hyperalgesia, inflammation and antagonist
2) Confidence 0.14 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14661069 Disease Relevance 1.09 Pain Relevance 0.87
The selective regulation of TTX-S I(Na) was supported by reductions in transcript and protein levels of TTX-S Na(v)1s, particularly Na(v)1.7.
Regulation (regulation) of TTX-S
3) Confidence 0.13 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16870743 Disease Relevance 0.66 Pain Relevance 0.75
The activation of alpha2-adrenoceptors by clonidine did not affect sIPSCs in PCs at postnatal days (P) 8-10, when PCs showed a few sIPSCs and interneurons in the molecular layer (MLIs) did not cause action potential (AP).
Neg (not) Regulation (affect) of sIPSCs in interneurons associated with action potential and clonidine
4) Confidence 0.04 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691636 Disease Relevance 0 Pain Relevance 0.66
We next tested whether ATPA has selective effects on glycinergic and/or GABAergic sIPSCs.
Spec (whether) Regulation (effects) of sIPSCs associated with gabaergic
5) Confidence 0.00 Published 2006 Journal Mol Pain Section Body Doc Link PMC1570342 Disease Relevance 0 Pain Relevance 0.71

General Comments

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