INT8423

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Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 11.69
Pain Relevance 8.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cntf) cytosol (Cntf) extracellular space (Cntf)
growth (Cntf) nucleus (Cntf) cytoplasm (Cntf)
Anatomy Link Frequency
spinal cord 3
striatum 3
funiculus 2
neurons 2
lung 2
Cntf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 4 99.66 Very High Very High Very High
c fibre 90 99.24 Very High Very High Very High
Central nervous system 263 99.00 Very High Very High Very High
Spinal cord 804 98.92 Very High Very High Very High
chemokine 28 98.72 Very High Very High Very High
Glutamate 600 98.62 Very High Very High Very High
cytokine 138 98.12 Very High Very High Very High
allodynia 198 97.84 Very High Very High Very High
ketamine 43 97.64 Very High Very High Very High
substance P 3 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 1262 99.28 Very High Very High Very High
Spinal Cord Injury 645 98.92 Very High Very High Very High
Frailty 55 98.92 Very High Very High Very High
Disease 211 98.56 Very High Very High Very High
Optic Nerve Injuries 2 98.24 Very High Very High Very High
Neuropathic Pain 360 97.84 Very High Very High Very High
Neurological Disease 21 97.40 Very High Very High Very High
Hyperalgesia 108 97.28 Very High Very High Very High
Immunization 36 95.24 Very High Very High Very High
Middle Cerebral Artery Infarction 98 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings further validate CNTF overexpression as a neuroprotective strategy for the treatment of HD and other neurological diseases characterized by glutamate-mediated neurodegeneration.


Gene_expression (overexpression) of CNTF associated with glutamate, neurological disease and disease
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.88 Pain Relevance 0.24
These data clearly show that CNTF overexpression in the striatum is neuroprotective against QA excitotoxicity.


Gene_expression (overexpression) of CNTF in striatum
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.11
It may be that despite being able to suppress expression of axon-growth-inhibitory CSPGs, GDAsCNTF and GRPs transplanted in acute spinal cord injuries fail to actively support axon growth and/or express molecules themselves that actively inhibit it.
Gene_expression (expression) of GDAsCNTF in spinal cord associated with spinal cord
3) Confidence 0.62 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.70 Pain Relevance 0.25
Compared with GDAsBMP, GDAsCNTF express elevated levels of the axon-growth-inhibitory chondroitin sulfate proteoglycans (CSPGs) NG2 (Figure 2a,b) and phosphacan (Figure 2c,d), both of which are also expressed at high levels in glial scar tissue [18].
Gene_expression (express) of GDAsCNTF associated with cicatrix
4) Confidence 0.62 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.35 Pain Relevance 0.21
The low-level expression of axon-growth-inhibitory CSPGs by GDAsBMP compared with GDAsCNTF, both in vitro and within spinal cord injuries, is one potential mechanism that might account for the clear difference in the ability of these astrocytes to support axon growth.


Gene_expression (expression) of GDAsCNTF in spinal cord associated with spinal cord
5) Confidence 0.62 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.82 Pain Relevance 0.51
A number of studies have demonstrated that CNTF is a potent neuroprotective factor for striatal MSNs in animal HD models, including rodents and primates.
Gene_expression (neuroprotective) of CNTF associated with disease
6) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.10 Pain Relevance 0.20
Finally, NMDA/AMPA ratio (Fig. 3C) was not significantly different between CNTF and LacZ slices (0.49±0.06, N?
Gene_expression (slices) of CNTF
7) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.28
QA was injected in the striatum of Vehicle, LacZ and CNTF rats and the volume of QA-induced lesions was measured on NeuN stained sections (N?
Gene_expression (rats) of CNTF in striatum
8) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.26
These data indicate that CNTF overexpression reduces the relative concentration and/or time course of glutamate in the synaptic cleft, suggesting an enhanced glutamate uptake.
Gene_expression (overexpression) of CNTF in synaptic cleft associated with glutamate
9) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.41
Frequency and amplitude of spontaneous EPSCs (sEPSCs) were also not changed by CNTF (Fig. 3B): average sEPSC frequency was 4.62±1.5 and 4.02±2.6 Hz, and average amplitude was 8.24±3.10 and 8.45±2.5 pA, respectively in LacZ and CNTF slices (N?
Neg (not) Gene_expression (changed) of CNTF
10) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0 Pain Relevance 0.19
, and a decrease in vascular endothelial growth factor (VEGF) and CNTF, levels (Figure 5A), whereas pretreatment with pristane preserved the normal VEGF and CNTF levels in the lung and significantly decreased IL-1?
Gene_expression (levels) of CNTF in lung
11) Confidence 0.54 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.21 Pain Relevance 0.34
, and a decrease in vascular endothelial growth factor (VEGF) and CNTF, levels (Figure 5A), whereas pretreatment with pristane preserved the normal VEGF and CNTF levels in the lung and significantly decreased IL-1?
Gene_expression (levels) of CNTF in lung
12) Confidence 0.54 Published 2010 Journal Respir Res Section Body Doc Link PMC3009635 Disease Relevance 0.16 Pain Relevance 0.32
Moreover, transplantation of GDAsCNTF or undifferentiated GRPs resulted in both mechanical allodynia and thermal hyperalgesia, problems that were not caused by transplantation of GDAsBMP.
Gene_expression (transplantation) of GDAsCNTF associated with allodynia and thermal hyperalgesia
13) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.78 Pain Relevance 0.71
Transplants of either GDAsBMP, GDAsCNTF or undifferentiated GRPs were injected in an identical pattern into injuries of the dorsolateral funiculus and a total of 6 ?
Gene_expression (either) of GDAsCNTF in funiculus associated with injury
14) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.36 Pain Relevance 0.21
Transplants of either GDAsBMP, GDAsCNTF or undifferentiated GRPs were injected in an identical pattern into injuries of the dorsolateral funiculus and a total of 6 ?
Gene_expression (Transplants) of GDAsCNTF in funiculus associated with injury
15) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.41 Pain Relevance 0.21
Transplantation of GDAsCNTF or GRPs fails to suppress atrophy of red nucleus neurons
Gene_expression (Transplantation) of GDAsCNTF in neurons associated with frailty
16) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.80 Pain Relevance 0.08
GDAsCNTF and GRPs promote sprouting of CGRP c-fibers after spinal cord injury
Gene_expression (promote) of GDAsCNTF in spinal cord associated with c fibre and spinal cord
17) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 1.60 Pain Relevance 0.79
Characterization of transplanted GDAsCNTF in vivo
Gene_expression (transplanted) of GDAsCNTF
18) Confidence 0.54 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.50 Pain Relevance 0.06
A phase I clinical trial confirmed the safety of local brain administration of encapsulated cells genetically engineered to produce CNTF and reported a recovery of somatosensory evoked potentials in patient implanted with capsules releasing the largest amount of CNTF [8].
Gene_expression (produce) of CNTF in capsules
19) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.59 Pain Relevance 0.29
Using lentivirus-mediated CNTF overexpression in the rat striatum, whole-cell patch-clamp and extracellular electrophysiological recordings on corticostriatal slices, we provide evidence that CNTF neuroprotective effects against QA are mediated through an enhanced glutamate uptake by activated astrocytes.


Gene_expression (overexpression) of CNTF in astrocytes associated with glutamate
20) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798716 Disease Relevance 0.05 Pain Relevance 0.27

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