INT84232

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.84
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 8
liver 2
neurons 2
nucleus 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 53 100.00 Very High Very High Very High
agonist 24 99.98 Very High Very High Very High
opiate 5 99.32 Very High Very High Very High
isoflurane 5 99.24 Very High Very High Very High
parabrachial 1 98.44 Very High Very High Very High
narcan 1 97.48 Very High Very High Very High
antagonist 75 97.12 Very High Very High Very High
opioid receptor 262 96.80 Very High Very High Very High
Antinociceptive 13 96.00 Very High Very High Very High
qutenza 79 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

64 98.76 Very High Very High Very High
Cancer 5 95.12 Very High Very High Very High
Nociception 19 88.68 High High
Pain 28 84.08 Quite High
Ganglion Cysts 4 74.08 Quite High
Toxicity 3 67.60 Quite High
Apoptosis 1 55.68 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

30 54.56 Quite High
INFLAMMATION 2 46.00 Quite Low
Colon Cancer 3 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both opiate and alpha2-adrenoceptor agonists reduced formalin-induced c-fos gene transcription and nocifensive behavior via their cognate receptors.
Negative_regulation (reduced) of Transcription (transcription) of c-fos gene associated with agonist and opiate
1) Confidence 0.58 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10497900 Disease Relevance 0.08 Pain Relevance 0.87
This effect was, however, not generalized throughout the brain as PGE2 inhibition failed to abolish IL-1beta-induced c-fos transcription in the nucleus of the solitary tract, parabrachial nucleus, bed nucleus of the stria terminalis, and the circumventricular organs.
Neg (failed) Negative_regulation (abolish) of Transcription (transcription) of c-fos in nucleus associated with parabrachial
2) Confidence 0.57 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10800959 Disease Relevance 0 Pain Relevance 0.37
ODC inactivation is associated with decreased transcription of the growth-related c-myc and c-fos genes.
Negative_regulation (decreased) of Transcription (transcription) of c-fos
3) Confidence 0.57 Published 2007 Journal Biochem. Soc. Trans. Section Abstract Doc Link 17371277 Disease Relevance 0.46 Pain Relevance 0
Needle manipulation was also effective in suppressing the mRNA expression of pain-related genes such as Fos, opioid receptor-like 1, tachykinin 1, tachykinin receptor 1, mu-opioid receptor and 5-hydroxytryptamine receptor 2A in the spinal cord.
Negative_regulation (suppressing) of Transcription (expression) of Fos in spinal cord
4) Confidence 0.44 Published 2010 Journal Neurol. Res. Section Body Doc Link 20034454 Disease Relevance 0.07 Pain Relevance 0
The low level of c-fos transcription in the laminae of the dorsal spinal cord made it compulsory to run the experiments involving HCl and capsaicin strictly in parallel with those involving the respective control/vehicle solution.
Negative_regulation (level) of Transcription (transcription) of c-fos in spinal cord associated with qutenza and spinal cord
5) Confidence 0.42 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.07 Pain Relevance 0.58
Kozinn and co-workers demonstrated that lower concentrations of propofol inhibits N-methyl-D-aspartate (NMDA) receptor activation of MAPK/ERK pathway and c-Fos transcription in hippocampal neurons[14].
Negative_regulation (inhibits) of Transcription (transcription) of c-Fos in neurons
6) Confidence 0.42 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.06 Pain Relevance 0.06
The expression of c-fos mRNA was transiently increased in the brain, and more strikingly and for longer times, in the kidney with all three anesthetics; the expression of c-fos mRNA was decreased in the heart with isoflurane and pentobarbital and increased in the liver with isoflurane and propofol.
Negative_regulation (decreased) of Transcription (expression) of c-fos mRNA in liver associated with isoflurane
7) Confidence 0.32 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10781476 Disease Relevance 0 Pain Relevance 0.29
Consistent with this view, we found that administration of H2S decreased spinal cord expression of cFos mRNA.
Negative_regulation (decreased) of Transcription (expression) of cFos in spinal cord associated with spinal cord
8) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.16 Pain Relevance 0.80
Thus, Na2S administration abrogated cFos mRNA expression induced in the spinal cord by CRD (Figure 1, panel D, p < 0.05 versus control).

?

Negative_regulation (abrogated) of Transcription (expression) of cFos in spinal cord associated with spinal cord
9) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0.14 Pain Relevance 0.82

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox