INT8424

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 8.01
Pain Relevance 8.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
plasma 4
macrophages 2
lactotrophs 2
peripheral neurons 2
Sciatic nerve 2
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 58 100.00 Very High Very High Very High
Neurotransmitter 11 100.00 Very High Very High Very High
substance P 27 99.90 Very High Very High Very High
electroacupuncture 336 99.48 Very High Very High Very High
Arthritis 120 99.48 Very High Very High Very High
rheumatoid arthritis 96 99.44 Very High Very High Very High
Sciatic nerve 10 99.34 Very High Very High Very High
Acupuncture 96 99.32 Very High Very High Very High
Inflammation 266 99.26 Very High Very High Very High
neuropeptide release 1 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 14 99.80 Very High Very High Very High
Arthritis 90 99.48 Very High Very High Very High
Rheumatoid Arthritis 104 99.44 Very High Very High Very High
INFLAMMATION 262 99.26 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

16 98.76 Very High Very High Very High
Experimental Arthritis 36 98.36 Very High Very High Very High
Pressure And Volume Under Development 43 97.98 Very High Very High Very High
Hypersensitivity 4 97.72 Very High Very High Very High
Body Weight 56 97.34 Very High Very High Very High
Ganglion Cysts 6 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data demonstrated that VIP likely act as an important mediator of the anti-inflammatory role of EA, which was supported by the findings that the EA treatment could markedly enhanced the expression of VIP in the synovial tissue, and moreover, the synovial VIP levels were negatively correlated with the inflammation scores.
Positive_regulation (enhanced) of Gene_expression (expression) of VIP associated with inflammation and electroacupuncture
1) Confidence 0.70 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.24 Pain Relevance 1.09
Accompanying with the anti-inflammatory action, EA treatment resulted in an enhancement of VIP expression in the synovial tissue.
Positive_regulation (enhancement) of Gene_expression (expression) of VIP associated with inflammation and electroacupuncture
2) Confidence 0.70 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.14 Pain Relevance 0.95
In conclusion, our results indicated, for the first time, that the EA treatment at Zusanli (ST 36), Xuanzhong (GB39), and Shenshu (BL23) could decrease the body weight loss and suppress the paw edema and inflammatory reaction in rats with Freund's adjuvant-induced arthritis, at least partially, via upregulating the VIP expression.
Positive_regulation (upregulating) of Gene_expression (expression) of VIP in body associated with pressure and volume under development, body weight, inflammation, electroacupuncture and arthritis
3) Confidence 0.70 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.19 Pain Relevance 0.75
Some neurons whose axons were spared by partial injury may also increase neuropeptide Y or vasoactive intestinal peptide expression.
Spec (may) Positive_regulation (increase) of Gene_expression (expression) of vasoactive intestinal peptide in neurons associated with injury and neuropeptide
4) Confidence 0.60 Published 1998 Journal Neuroscience Section Abstract Doc Link 9697128 Disease Relevance 0.61 Pain Relevance 0.88
The increased expression of vasoactive intestinal polypeptide (VIP) in injured peripheral neurons was studied.
Positive_regulation (increased) of Gene_expression (expression) of VIP in peripheral neurons
5) Confidence 0.50 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2124338 Disease Relevance 0.19 Pain Relevance 0.35
This is followed by a slower change in the levels of the inhibitory neurotransmitter galanin and VIP.
Positive_regulation (change) of Gene_expression (levels) of VIP associated with neurotransmitter
6) Confidence 0.48 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 16084604 Disease Relevance 0.31 Pain Relevance 0.84
0.483, P = .0026), suggesting that the anti-inflammatory effects of EA at acupoint may be mediated through the up-regulation of VIP expression.


Positive_regulation (up-regulation) of Gene_expression (expression) of VIP associated with inflammation and electroacupuncture
7) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 0.89 Pain Relevance 0.77
Given the modulation of VIP by acupuncture and the importance of VIP in experimental arthritis, we hypothesized that the action of acupuncture on RA may be attributable to the elevation of VIP expression and the subsequent suppression of the arthritis.
Positive_regulation (elevation) of Gene_expression (expression) of VIP associated with rheumatoid arthritis, acupuncture, experimental arthritis and arthritis
8) Confidence 0.47 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 1.13 Pain Relevance 0.96
Fluoxetine improved depressed behavior, increased VIP expression and decreased CRF expression in plasma and the duodenal tissue of depressed rats.
Positive_regulation (increased) of Gene_expression (expression) of VIP in plasma
9) Confidence 0.46 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 18023100 Disease Relevance 0 Pain Relevance 0
VIP diffusing from VIP-Rh-Lip contained in ED3-positive macrophages could induce VIP production in adjacent T cells.
Positive_regulation (induce) of Gene_expression (production) of VIP in macrophages
10) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.06 Pain Relevance 0.08
Thus, VIP detected in T lymphocytes could either represent VIP attached to its membranous receptor or VIP produced by T cells in response to VIP stimulation as previously reported [35].
Positive_regulation (response) of Gene_expression (produced) of VIP in T cells
11) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2268712 Disease Relevance 0.11 Pain Relevance 0.07
The results of the computer image analysis further demonstrated the EA treatment following FCA significantly increased the VIP expression in the synovial tissue in comparison with the FCA alone (116.46 ± 57.88 versus 59.27 ± 16.86, P < .01; Figure 7).
Positive_regulation (increased) of Gene_expression (expression) of VIP associated with electroacupuncture
12) Confidence 0.41 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952296 Disease Relevance 0.20 Pain Relevance 0.47
Substance P and vasoactive intestinal peptide (VIP) levels were significantly higher in the damaged mucosa in rats treated with ethanol, as was the mucosal generation of leukotriene B4 (LTB4) and cysteinyl-containing leukotrienes.
Positive_regulation (generation) of Gene_expression (higher) of vasoactive intestinal peptide associated with substance p
13) Confidence 0.36 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7510607 Disease Relevance 0.17 Pain Relevance 0.58
After oestrogen treatment, VIP expression is increased and is present in a subpopulation of lactotrophs also containing galanin (289).
Positive_regulation (increased) of Gene_expression (expression) of VIP in lactotrophs
14) Confidence 0.31 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.06 Pain Relevance 0.05
These alterations of VIP, CCK and NPY may play a role in the pathogenesis of IBS.


Positive_regulation (alterations) of Gene_expression (alterations) of VIP
15) Confidence 0.24 Published 2008 Journal Digestion Section Body Doc Link 18948690 Disease Relevance 0 Pain Relevance 0
The levels of somatostatin and substance P in fasting plasma and in the sigmoid were not different between IBS patients and control subjects (p > 0.05), but the levels of VIP in sigmoid tissue or in plasma were higher in IBS patients than in control group (p < 0.01).
Positive_regulation (higher) of Gene_expression (levels) of VIP in plasma
16) Confidence 0.22 Published 2008 Journal Digestion Section Body Doc Link 18948690 Disease Relevance 0 Pain Relevance 0
Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide (VIP), substance P, and somatostatin severalfold while significantly reducing levels of neuropeptide Y (NPY).
Positive_regulation (increased) of Gene_expression (levels) of intestinal peptide in Sciatic nerve associated with neuropeptide, somatostatin, sciatic nerve and substance p
17) Confidence 0.00 Published 1992 Journal Dev. Biol. Section Abstract Doc Link 1372570 Disease Relevance 0 Pain Relevance 0.47

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